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CC DAY-3 PROTEINS Flashcards

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1
Q

macromolecules made of amino acids, with each amino being linked to another via a peptide bond

A

proteins

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2
Q

formed when carboxyl group of one amino acid links to the amino group of another amino acid

A

peptide bond

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3
Q

end of protein structure with a free amino group

A

n-terminal

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4
Q

end of protein structure with a free carboxyl group

A

c-terminal

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5
Q

what is the nitrogen content of proteins

A

16%

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6
Q

a balance between anabolism and catabolism

A

nitrogen balance

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7
Q

it is composed of protein (apoprotein) abd nonprotein (prosthetic group) components

A

conjugated proteins

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8
Q

polypeptides composed of only amino acids

A

simple proteins

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9
Q

protein responsible for water balance

A

albumin

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10
Q

indicator of malnutrition

A

prealbumin/transthyretin

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11
Q

landmark to confirm specimen is CSF

A

prealbumin/transthyretin

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12
Q

Transports thyroxine and retinol by binding retinol binding protein

A

prealbumin/transthyretin

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13
Q

Half life of prealbumin/transthyretin

A

1-2 days

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14
Q

sensitive to acute malnutrition

A

prealbumin/transthyretin

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15
Q

earlier marker of malnutrition

A

prealbumin/transthyretin

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16
Q

half life of albumin

A

18-20 days

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17
Q

sensitive to chronic malnutrition

A

albumin

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18
Q

negative APR

A

albumin
tranferrin

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18
Q

major contributor to oncotic pressure

A

albumin

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19
Q

rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin

A

Analbuminemia

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20
Q

is analbuminemia congenital?

A

yes

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21
Q

presence if akbumin that has unusual molecular characteristics demonstrated by the presence of two albumin bands

A

bisalbuminemia

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22
Q

ALPHA1 GLOBULINS

Protease inhibitor 90% of a a1-globulin band

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

a

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23
Q

inactivates trypsin and other proteolytic enzymes

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

a

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24
principal fetal protein a. AAT b. AFP c. alpha1-acid glycoprotein d. Gc-globulin e. a1-lipoprotein f. alpha1-antichynitrypsin
b
25
AFP is detectable in maternal blood up to ____
7th to 8th month of gestation
26
when AFP screening is done?
between 15 and 20 weeks of gestation
27
AKA: Orosomucoid a. AAT b. AFP c. alpha1-acid glycoprotein d. Gc-globulin e. a1-lipoprotein f. alpha1-antichynitrypsin
c
28
usefil diagnostic tool in neonatal bacterial infection a. AAT b. AFP c. alpha1-acid glycoprotein d. Gc-globulin e. a1-lipoprotein f. alpha1-antichynitrypsin
c
29
transports lipids a. AAT b. AFP c. alpha1-acid glycoprotein d. Gc-globulin e. a1-lipoprotein f. alpha1-antichynitrypsin
e
30
serine protease inhibitor a. AAT b. AFP c. alpha1-acid glycoprotein d. Gc-globulin e. a1-lipoprotein f. alpha1-antichynitrypsin
f
31
Vital component of amyloid deposits in the brain a. AAT b. AFP c. alpha1-acid glycoprotein d. Gc-globulin e. a1-lipoprotein f. alpha1-antichynitrypsin
f
31
positive risk for atherosclerosis a. AAT b. AFP c. alpha1-acid glycoprotein d. Gc-globulin e. a1-lipoprotein f. alpha1-antichynitrypsin
e
32
transports vitamin D and binds actin a. AAT b. AFP c. alpha1-acid glycoprotein d. Gc-globulin e. a1-lipoprotein f. alpha1-antichynitrypsin
d
32
increase in alzheimers disease a. AAT b. AFP c. alpha1-acid glycoprotein d. Gc-globulin e. a1-lipoprotein f. alpha1-antichynitrypsin
f
32
copper carrying protein with enzymatic activities a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
b
32
ALPHA 2 GLOBULINS binds free hemoglobin to prevent urinary loss a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
a
33
marker of wilsons disease a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
b
34
largest non-Ig plasma protein (800,000 D) a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
C
35
increase in stressful conditions a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
a
36
increase in acute inflammation a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
a
37
decrease in intravascular hemolysis a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
a
38
decrease in malnutrition a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
b
39
decrease in wilsons disease a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
b
40
decrease in menkes syndrome a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
b
41
increase in neprothic syndrome a. haptoglobin b. ceruloplasmin c. a2-macroglobulin
c
42
BETA GLOBULINS transports lipids (VLDL) a.pre-b-lipoprotein b. b-lipoprotein c. transferrin d. hemopexin e. B2-microglobulin f.Complement g.fibrinogen h. C-reactive protein
a
43
BETA GLOBULINS transports lipids (LDL) a.pre-b-lipoprotein b. b-lipoprotein c. transferrin d. hemopexin e. B2-microglobulin f.Complement g.fibrinogen h. C-reactive protein
b
44
BETA GLOBULINS binds free ferric iron a.pre-b-lipoprotein b. b-lipoprotein c. transferrin d. hemopexin e. B2-microglobulin f.Complement g.fibrinogen h. C-reactive protein
c
45
BETA GLOBULINS binds free Heme a.pre-b-lipoprotein b. b-lipoprotein c. transferrin d. hemopexin e. B2-microglobulin f.Complement g.fibrinogen h. C-reactive protein
d
46
BETA GLOBULINS single polypeptide chain that is a components of the light chain of HLA Class 1 a.pre-b-lipoprotein b. b-lipoprotein c. transferrin d. hemopexin e. B2-microglobulin f.Complement g.fibrinogen h. C-reactive protein
e
47
BETA GLOBULINS freely filtered by the glomerulus and completely reabsorbed a.pre-b-lipoprotein b. b-lipoprotein c. transferrin d. hemopexin e. B2-microglobulin f.Complement g.fibrinogen h. C-reactive protein
e
47
BETA GLOBULINS precursor of fibrin clot a.pre-b-lipoprotein b. b-lipoprotein c. transferrin d. hemopexin e. B2-microglobulin f.Complement g.fibrinogen h. C-reactive protein
g
48
BETA GLOBULINS Cardiac marker and inflammatory marker a.pre-b-lipoprotein b. b-lipoprotein c. transferrin d. hemopexin e. B2-microglobulin f.Complement g.fibrinogen h. C-reactive protein
h
48
BETA GLOBULINS primary APR a.pre-b-lipoprotein b. b-lipoprotein c. transferrin d. hemopexin e. B2-microglobulin f.Complement g.fibrinogen h. C-reactive protein
H
49
NON-INVASIVE PROCEDURE USING VAGINAL SECRETIONS TO DETECT THREATENED ABORTION
B-HCG
49
gamma globulins
immunoglobulins
50
51
52
Oxygen carrier in muscles
myoglobin
53
earliest cardiac marker but non specific
myoglobin
54
most specific cardiac marker
toponin
55
placental adeherence to the uterus and increase in preterm labor and delivery
fetal fibronectin
56
plasma protein that is also a marker for nutritional status
fibronectin
57
marker of bone resorption
cross-linked c-telopeptides
58
B-trace protein AKA:
Prostaglandin D synthase
59
Marker for CSF leakage
60
indirect measure of GFR
Cystatin-C
61
direct measure of GFR
Inulin
62
marker of obesity (decrease)
adiponectin
63
63
64
increase alpha 1 and alpha 2 a. acute inflammation b. chronic infection c. cirrhosis d. monoclonal gammopathy e. nephrotic syndrome f. alpha-1-antitrypsin deficiency
a
65
increase alpha 1, alpha 2, gamma a. acute inflammation b. chronic infection c. cirrhosis d. monoclonal gammopathy e. nephrotic syndrome f. alpha-1-antitrypsin deficiency
b
66
beta gamma bridging a. acute inflammation b. chronic infection c. cirrhosis d. monoclonal gammopathy e. nephrotic syndrome f. alpha-1-antitrypsin deficiency
c
67
M spike a. acute inflammation b. chronic infection c. cirrhosis d. monoclonal gammopathy e. nephrotic syndrome f. alpha-1-antitrypsin deficiency
d
68
decrease albulin, increase alpha 2 a. acute inflammation b. chronic infection c. cirrhosis d. monoclonal gammopathy e. nephrotic syndrome f. alpha-1-antitrypsin deficiency
e
69
decrease alpha 1 a. acute inflammation b. chronic infection c. cirrhosis d. monoclonal gammopathy e. nephrotic syndrome f. alpha-1-antitrypsin deficiency
f
70
albumin:globulin ratio
2:1
71
Reference method for measuring proteins
Kjeldahl
72
method for protein: measurement of refractive index
refractometry
73
What method is recommended for measuring total protein
biuret
73
reagents used in salt precipitation (methods for albumin
sodium sulfate, sodium sulfite, ammonium sulfate, and methanol
73
method for protein: formation of voilet colored chelate between cuprous ions and peptide bonds
Biuret
73
METHOD OF MEASURING ALBUMIN
salt precipitation
74
non-specific dye for albumin
methyl orange
75
specific for albumin but subject to interferences
HABA
76
interferences in HABA
Hemolysis-increase Heparin-increase Bilirubin-decrease Salicylates-slight dec
76
Sensitive, most commonly used dye binding for albumin
BCG- Bromcresol Green
77
absorbs strongly below 500 nm with additional maximum absorbance at 630 nm
BCG- Bromcresol Green
78
specific and precise
BCP- Bromcresol Purple

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