CC2

Question 1

Elevation of serum alkaline phosphatase may be seen in:
1. Hepatobiliary disease
2. Growing children
3. Hyperparathyroidism
4. Germ cell tumor of the testicle

Answer 1

1 AND 2

Question 2

The following statements are TRUE of lactate
Dehydrogenase
1. There is an elevated serum LD in Acute
Myocardial Infraction
2. There is a decreased LD in Megaloblastic
Anemia
3. There are 4 monomers in the LD isoenzyme
structure
4. LD6 isoenzyme is seen only in patient with
muscle disorders

Answer 2

1 and 3

Question 3

Amylase is an enzyme useful in diagnosis of Acute
pancreatitis. Which of the following statements
correctly describes amylase?
1. Amylase is elevated in acute pancreatitis,
mumps, parotitis, and perforated peptic ulcer
2. Amylase cleaves glycosidic bons of
polysaccharides
3. It is the largest of all enzyme in terns of
molecular weight
4. The p-type isoenzyme migrates fastest while
the S-type isoenzyme migrates slowest in
amylase isoenzyme electrophoresis

Answer 3

1 and 2

Question 4

Which of the following statements is TRUE of
isoenzyme LD-2?

Answer 4

IT IS PRESENT IN GREATEST
AMOUNT IN NORMAL HEART TISSUE

Question 5

Which of the following enzyme is considered a
newborn screening marker?

Answer 5

G-6-PD

Question 6

A scanning of CK isoenzyme fractionation two
peaks: a slow cathodic peak (CK-MM) an
intermediate peak (CK-MB). A possible
interpretation for this pattern is:

Answer 6

MYOCARDIAL
INFRACTION

Question 7

The clinical significance of an elevated acid
phosphatase is:

Answer 7

PROSTATIC DISEASE

Question 8

Tests for acid phosphatase detect levels of the
enzyme from tissues such as:

Answer 8

LIVER
SPLEEN,
POSTATE
PLATELETS

Question 9

Select the product formed from the forward
reaction of AST:

Answer 9

OXALOACETATE AND
GLUTAMATE

Question 10

Creatine kinase is frequently elevated in disorders such as acute myocardial infraction and:

Answer 10

DUCHENNE MUSCULAR DYSTROPHY

Question 11

This enzyme is the most specific marker of acute pancreatitis and remains elevated for 48hrs in the blood circulation:

Answer 11

LIPASE

Question 12

This enzyme which affects the cell membrane and microsomal fractions, is a sensitive indicator of occult alcoholism?

Answer 12

GGT

Question 13

Which two condition can “physiologically” elevate serum alkaline phosphatase?

Answer 13

GROWTH, 3RD TRIMESTER OF PREGNANCY

Question 14

A physician suspects his patient has pancreatitis. Which test(s) would be most indicative of this disease?

Answer 14

AMYLASE

Question 15

Which of the following chemical determinations
may be of help in establishing the presence of
seminal fluid?

Answer 15

ACID PHOSPHATASE

Question 16

Increased total serum Lactate Dehydrogenase (LD) activity, confined to fractions 4 and 5, is most likely to be associated with:

Answer 16

ACUTE VIRAL
HEPATITIS

Question 17

Regan isoenzyme has the same properties as
alkaline phosphatase that originates in the:

Answer 17

PLACENTA

Question 18

The most sensitive enzymatic indicator for liver
damage from ethanol intake is

Answer 18

GGT

Question 19

A serum sample drawn in the emergency room
from a 42-year-old man yielded the following
laboratory results:
CK: 185 units (Normal = 15-160)
AST: 123 units (Normal = 0-48)
CK-MB: 6 units (Normal = 2012)
Which of the following conditions might account for these values?

Answer 19

CRUSH INJURY TO THE THIGH

Question 20

Which of the following enzymes catalyzes the
conversion of starch to glucose and maltose?

Answer 20

AMYLASE

Question 21

Which of the following is a glycolytic enzyme that catalyze the cleavage of fructose-1.6-diphosphate to glyceraldehyde -3-phosphate and dihydroxyacetone phosphate?

Answer 21

PHOSPHOFRUCTOKINASE

Question 22

Which of the following sets of results would be
consistent with macroamylasemia?

Answer 22

INCREASED SERUM AMYLASE AND NORMAL
URINE AMYLASE VALUE

Question 23

Isoenzyme assays are performed to improve:

Answer 23

SPECIFICITY

Question 24

What specimen preparation is commonly used to perform the alkaline phosphatase isoenzyme
determination?

Answer 24

SERUM IS DIVIDED INTO TWO ALIQUOTS, ONE IS HEATED AT 56C AND THE OTHER IS UNHEATED

Question 25

As the temperature is increased from 25C to 37C in the GGT reaction, the activity of the reaction

Answer 25

IS DOUBLED

Question 26

One method to enhance the differentiation of bone from liver alkaline phosphatase isoenzyme is to pretreat an aliquot of the sperm specimen.

Answer 26

BY HEATING AT 56C

Question 27

Which of the following may be associated with organophosphate poisoning?

Answer 27

CHOLINESTERASE

Question 28

Which of the following may be associated with macro-CK?

Answer 28

A AND C ARE BOTH CORRECT

Question 29

In an adult, a normal serum Gamma Glutamyl Transferase level with an elevated serum Alkaline phosphatase may be suggestive of:

Answer 29

BONE DISEASE

Question 30

Which of the following may be associated with the creatine kinase isoenzyme?

Answer 30

BOTH B AND C ARE CORRECT

Question 31

In pesticide poisoning, a decrease in enzyme activity is associated with

Answer 31

CHOLINESTERASE

Question 32

Which of the following is considered as a gold standard test for growth hormone deficiency?

Answer 32

INSULIN TOLERANCE TEST

Question 33

Composition of Thyroid stimulating hormone, except:

Answer 33

GAMMA SUBUNITS

Question 34

It is the regulator of adrenal and androgen synthesis in human.

Answer 34

ACTH

Question 35

The main stimulus for the uptake of iodide by the thyroid gland.

Answer 35

TSH

Question 36

It indirectly mediates metabolic and anabolic actions of growth hormone.

Answer 36

A AND C

Question 37

Most abundant of all the pituitary hormones.

Answer 37

GROWTH HORMONES

Question 38

Adult Growth hormone deficiency is due to:

Answer 38

PITUITARY ADENOMA

Question 39

Cell of the Pituitary gland that secretes Prolactin.

Answer 39

LACTOTROPH

Question 40

It is also Known as neurohypophysis.

Answer 40

POSTERIOR PITUITARY