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Flashcards in Cell Bio of the Lungs Deck (15):
0

How does the epithelium of the bronchioles differ from that of the trachea and bronchi? (2 things)

Bronchioles have simple cuboidal epithelium (vs. pseuodostratified ciliated).
Bronchioles have Clara cells instead of goblet cells.

1

What is the cartilage like in the bronchi?

Irregular plates (in contrast to the C-shaped rings of the trachea)

2

Do the bronchioles have glands?

Nope.

3

Which level of the bronchial tree has the greatest proportion of smooth muscle?

the bronchioles have the most smooth muscle.

4

What are the cells in pseudostratified ciliated columnar epithelium that don't reach the lumen?
What is their function?

Basal cells -these are stem cells for renewal of the epithelium.

5

Mucociliary transport involves 2 layers.

Yeah, the mucous layer and the watery layer.
The watery layer is where the cilia beat.

6

Which cells transport Cl- into the lumen?
What does this accomplish?

The ciliated epithelial cells move Cl- into the lumen.

7

What molecule confers motility to cilia?
What happens if this molecule is defective?

Dynein - a motor protein.
If defective, Kartagener's syndrome: male infertility (sperm immobile), chronic bronchitis, hearing problems.

9

2 cell types in the pseudostratified ciliated columnar (PCC) epithelium other than ciliated (30%) and goblet cells (30%)?
Function?

Basal cells (30%) - stem cells.
Neuroendocrine aka. Kulchitsky cells (10%) - secrete peptides... affect smooth muscle tone.

10

What's the largest (most proximal) air duct that defines a pulmonary lobule?

A terminal bronchiole.
Respiratory bronchioles, alveolar ducts, and alveoli branch off distally.

11

If you looked at the luminal wall of a terminal bronchiole, what cell type would you see the most of?

Clara cells.
(ciliated cells are much less common)

12

Function of Clara cells?

Surfactant production.
Cytochrome P-450 to metabolize airborne toxins.

13

What types of epithelial cells are in the alveoli?
Function?

Type I: Extremely thin, for gas exchange.
Type II: Surfactant production, stem cells.

Brush cells - monitor air quality?

14

What are Pores of Kohn?

Connections between adjacent alveoli.

15

What are some functions of alveolar macrophages?

Clean surfactant layer - removing dust and pollen.
Removing degraded surfactant.
Immune response - attracting PMNs.