Cell birth and death III Flashcards
(27 cards)
what is important during development?
apoptosis
what happens in polycystic disease?
too much apoptosis
what happens to chromatin during apoptosis?
it gets disorganized
dna ladder
characteristic of apoptosis
basic process of apoptosis (3)
induction
modulation
execution
induction
physiologic, damage related, therapy associated
2 major pathways induction
intrinsic and extrinsic
Modulation
Bcl proteins
intrinsic pathway only
Modulation
execution
caspases followed by endonucleases
directly responsible for blebbing
caspases
caspases
cytoskeletal cleaving, and activate endonuclease
inducers of apoptosis (3)
- physiological activators
- damage-related activators
- therapy associated
endonucleases are responsible for what we see in the
DNA ladder
can be both pro- and anti- apoptotic
Bcl family
reveals the molecules and mechanisms
Burkitt’s lymphoma
family members determines life and death
the ratio of pro- and anti- apoptotic Bcl family
what happens at immunologically privileged sites
the vascular endothelial cells express Fas ligand
mitochondrial pathway
intrinsic
too much p53
go to apoptosis
death recepto- intitated pathway
extrinsic
Bcl family involved with _________ pathway
intrinsic
lymphocytes expressing Fas receptor
undergo rapid apoptosis upon entering the privileged site
withdrawal of growth factors, hormones is first step in
intrinsic pathway
