cell cycle check point Flashcards
1
Q
g1/s is contolled by a mix of
A
intrinsic and extrinsiic signals
2
Q
Rb/E2F pathway is used in what checkpoint?
A
g1/s transition
3
Q
g1/s needs an intrinsic signal from DNA before it proceeds to s because what happens in the s phase
A
DNA replication occurs in s phase
4
Q
how does p53 pathway stop cell cycle progression
A
inhibits cdk 1 and 2 therefore stops hyperphosphorylation
5
Q
g2/m is mainly controlled by which cyclin?
A
cyclin B which increases activity of CDK1
6
Q
rb prevents
A
e2f from binding to DNA and therefore prevents cell cycle progression
7
Q
what happens when rb is phosphorylated
A
allows release of e2f which then binds to dna
