ECM Flashcards
1
Q
proteoglycans are composed of and name a type
A
GAGS covalently link to proteins, eg aggrecan
2
Q
what are integrins/what do they do?
A
transmembrane receptor proteins that bind to cell-surface ligands to promote cellular processes
3
Q
in focal adhesions
A
intarcellular domain of integrins binds with actin filaments,
extracellular domain can bind with ecm proteins
4
Q
name 3 components of ecm
A
fibrous proteins, glycosaminoglycans and proteoglycans
5
Q
name one role of GAGS
A
v negative charge so attracts cations causing osmosis
6
Q
what attaches epithelial cells to the basal lamina?
A
hemidesmosomes
