Cell-free fetal DNA-based noninvasive prenatal testing of aneuploidy TOG 2017 Flashcards
1
Q
From where does cffDNA originate?
A
Trophoblast
2
Q
What proportion of DNA in maternal plasma is cffDNA?
A
105
3
Q
When is cffDNA present
A
From 10 weeks until a few hours after delivery.
4
Q
Sensitivity and specificity for NIPT for Trisomy 21, 18 and 13, Monosomy X
A
21 0.99, 0.99
18 0.97, 0.99
13 0.90, 1.00
MX 0.92, 0.99
5
Q
Sensitivity of NIP for Trisomy 21 in twin pregnancy
A
0.93
False +ve 0.23%
