Stillbirth & intrauterine fetal death Flashcards
Definition of stillbirth
Baby delivered >24 weeks with no signs of life
Definition intrauterine death
Baby no signs of life in utero
Risk of still birth
1 in 200
What % of stillborn babies are SGA
1/3rd
How to diagnose intrauterine death
Colour doppler USS
Obtain 2nd opinion where possible
What Ix should be performed for late uterine death?
Clinical assessment
Bloods: FBC, U+E, LFT, Clotting + fibrinogen, CRP, BA
Infective: Blood culture, MSU, HVS, NAAT, viral screen, syphilis, topical infections
DM: Maternal glucose, Hba1c
Autoimmune: TFTs, thrombophilia screen, anti-red cell antibodies, anti-ro and anti-la, anti platelet antibodies
Toxic: Urrine toxicology (cocaine)
Placental: fetal blood, fetal seabs, placental swab Plancetal histology
Fetal and plancetal tissues for karyotype +/- patronal blood for karyotype
Post mortum - extrnal, autopsy, microscopy, X-ray, placenta and cord
Risk of DIC within 4 weeks
10%
Risk of DIC after 4 weeks
30%
It what % of cases is not specific cause of stillbirth identified?
50%
When should kleihaur test be sent if Rh-ve?
As soon as IUD diagnosed
If large FMH and kleuhauer high, what should be done?
Give higher dose anti-D and repeat kleihauer in 48hrs to ensure fetal red cells have cleared
If baby blood group not know an unable to get blood from cord or baby?
ffDNA from material blood shortly after birth
How to sex the baby?
Explain may be difficult before birth
2 healthcare professionals
If in doubt → QF-PCR or FISH
Can register without gender if parents do not want testing
What stillborn babies have chromosomal abnormality?
6-10%
What samples for karyotype?
Multiple samples of tissue required from different areas to reduce risk of culture failure
Need written consent from parents
e.g. skin failure rate 60%
