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HistoPath Lec 2ndYR 2ndSem Prelims > Cell Injury & Cell Death > Flashcards

Cell Injury & Cell Death Flashcards

1
Q

Alteration in cell structure or function due to stress or pathologic stimuli

A

Cellular Injury

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2
Q

Cell injury due to loss of oxygen level

A

Hypoxia

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3
Q

Cell injury due to accidents in any form of physically-induced type of injury

A

Physical Agents

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4
Q

Cell injury cthat can be harmful to the body

A

Chemical Agents and Drugs

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5
Q

Cell injury due to bacteria, parasites, and viruses

A

Infectious agents

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6
Q

Cell injury due to allergies

A

Immunologic Reaction

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7
Q

Cell injury due to no homeostasis in the tissues

A

Nutritional Imbalances

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8
Q

Earliest manifestation of cell injury

A

Generalizing swelling of cell

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9
Q

Due to increase in the number of free radicals

A

Blebbing of plasma membrane

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10
Q

Protruded portion of the plasma membrane

A

Blebs

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11
Q

Protruded portion of the plasma membrane

A

Blebs

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12
Q

Cell size in apoptosis

A

Reduced

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13
Q

Cell size in Necrosis

A

Enlarged (swelling)

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14
Q

Plasma membrane in apoptosis

A

Intact

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15
Q

Plamsa membrane in necrosis

A

Disrupted

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16
Q

Cellular contents in apoptosis

A

Intact

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17
Q

Cellular contents in necrosis

A

Enzymatic digestion (leaking)

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18
Q

Which cell death has adjacent inflammation

A

Necrosis (frequent)

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19
Q

Nucleus in apoptosis

A

Fragmentation into nucleosome-size fragments

20
Q

Nucleus in Necrosis

A

Pyknosis -> Karyorrhexis -> Karyolysis

21
Q

Which cell death is Physiologic

A

Apoptosis

22
Q

Which cell death is Pathologic

A

Necrosis

23
Q

Are cysteine proteases that can cleave the aspartic residue

A

Caspases

24
Q

Physiologic vs Pathologic

Eliminates cells that are no longer needed

A

Physiologic

25
Q

Physiologic vs Pathologic

Eliminates cells that are injured beyond repaire

A

Pathologic

26
Q

Types of necrosis according to location

A

Focal
Massive

27
Q

Location of necrosis only happened on a certain area of the body

A

Focal

28
Q

Location of necrosis is widespread

A

Massive

29
Q

Type of necrosis according to morphology

A

Coagulative
Liquefactive
Gangrenous
Caseous
Fat
Fibrinoid

30
Q

Necrosis where tissue is firm and eosinophilic

A

Coagulative

31
Q

Main cause of coagulative necrosis

A

Ischemia

32
Q

Lack/Low oxygen supply on Organ/Tissue

A

Ischemia

33
Q

Necrosis where tissue becomes liquid viscous mass due to digestion of dead cells

A

Liquefactive

34
Q

Liquefactive Necrosis occurs during

A

Microbial infection

35
Q

Liquefactive Necrosis affects

A

CNS

36
Q

Necrosis that is considered a “massive tissue death”

A

Gangrenous

37
Q

Combination of Coagulation and Liquefaction

A

Gangrenous

38
Q

2 types of Gangrenous necrosis

A

Dry
Wet

39
Q

Gangrene considered as sterile type with sharp demarcation line

A

Dry

40
Q

Determines up to what extent the gangrene is

A

Demarcation Line

41
Q

Gangrene where odor is more foul due to increase bacterial actions, and has rotting appearance

A

Wet

42
Q

Cheese-like necrosis, friable white appearance that is seen in tuberculosis and granuloma

A

Caseous

43
Q

Necrosis where lipase splits the neutral fats into fatty acids and glycerol

A

Fat

44
Q

Fatty Acids + Calcium causes

A

Fat Saponification (chalky-white appearance)

45
Q

Necrosis seen in immune reactions when antigen-antibody complexes are deposited in walls of arteries

A

Fibrinoid

46
Q

Immune complex + fibrin = ?

A

Fibrinoid

47
Q

Cell injury passed down through pregnancy

A

Genetic Abnormalities

HistoPath Lec 2ndYR 2ndSem Prelims (6 decks)

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