Cell M2: Module 3 Flashcards
(55 cards)
spontanrous chanes in muscle membrane potential in the absense of motor nerve stimulation
miniture end plate potential mEPPs
what was used to study NT release through exocytosis
neuromusclar junctions NMJs
what end plate potentials
stimulation of motor nerve generates
what ofte elcits an action potential in muscle
end plate potentials
the larger the depolarisatio of the cell membnrane the ____ openings of Ca 2+ voltage gated channels
more
what does the presynaptic injection of Ca2+ chealtors do
eliminates post synaptic potentials by blocking NT release
what are chelators
naturally occuring bind inhibitors
presynaptic injection of Ca2+ leads to
PSP - post synaptic potentials
what accounts for most of synaptic delay during membraane depolarization
delayed opening of Voltage gated calcium channels
neuropeptides
small peptides that are neurotrnamsittes
where are neuropeptides synthesized
in the soma from precursors at the endoplasmic reticulum to the golgi
do neuropeptides undergo reuptake
no, broken down by proteolytic enzymes
how are neurotransmitters trnasported into synaptic vesicles
agaisnt electrochemical gradient, using energy from vescular proton pump
compensart endocytosis menaing
plasma membrane needs to be held at constant material, so excocytosis of 1 = endocytosus of 1
how long does process from exocytossis to ready for endocytosis take
10-20 seconds
how long does a whole cycle of becoming ready for exocytosis to just being endocytosed takes
1 minutes
do all vesicules need to go thorgh endosomes?
not the recylcyed ones, the immeduate become synaptic vesicles
the recyling pool of SV is ___% big
20%
what is required for SV primin
SNARE proteins which form a SNARE complex
how does a SNARE complex work
a snare complex brings the - charged membranes together for fusion
synaptic vesicle exocytosis is mediated by
syntaxin
SNAP25
synaptobrevin
redily reusable pool of all SVs at CNS synapses is ___ % or ___ vseicles
2-4 % or 5-10 vesicles
why are some vesicles in recycling pool not readily reusable
they are availible for release after initial sitmulation
what happens to syntaxin, snap 25 and synaptobrvin to requrie enegery to bring negatively charged membrnes together
theyr alpha helices intertwined in coiled mess that produces energy
