Cell Receptors

Question 1

Ion Channel coupled Receptors/Ionotropic

Answer 1

fast acting; bind NTs; open and close channels

Question 2

G-protein coupled receptors

Answer 2

slow; long term effects; intracellular signaling; bind eicosanoids, Nts and peptide hormones; need GTP

Question 3

Enzyme coupled receptors

Answer 3

are enzymes or are activated by enzymes to perform intracellular signaling

Question 4

Receptor Tyrosine kinases (RTKs)

Answer 4

phosphorylate intracellular signaling proteins; bind GFs or membrane-bound ligands; are monomers that dimerize, phosphorylate their Tyr residues and activate signaling proteins

Question 5

Tyrosine Kinase Associated Receptors

Answer 5

bind cytokines, interleukins, integrins; monomers dimerize and activated soluble RTKs at the plasma membrane

Question 6

Cytokine receptors

Answer 6

bind cytokines and hormones; activate JAK/STAT signaling

Question 7

Protein tyrosine phosphatases

Answer 7

inhibits signaling pathways by terminating signals; removes P group from phosphotyrosines

Question 8

Receptor guanylyl cyclase

Answer 8

activates protein kinases, ion channels, and phosphodiesterases; domain stimulated and forms cGMP

Question 9

Receptor Ser/ Thr Kinase

Answer 9

binds TGF-beta; monomers heterodimerize and one P the other’s Ser/Thr residues; activates Smad pathway

Question 10

Notch

Answer 10

embryonic development; binds delta; Notch tail cleaved by proteases, Notch translocates to nucleus and acts as TF

Question 11

Frizzled

Answer 11

binds Wnt; beta-catenin is NOT phos, ubiq, and degraded and is able to translocate to the nucleus and induce transcription

Question 12

Patched

Answer 12

binds hedgehog; Smoothened prevents cytosolic Ci from being phos, ubiq, and degraded; Cytosolic Ci translocates to the nucleus and acts as a TF

Question 13

Death Receptors

Answer 13

bind cytokines, GFs and PAMPS; cytosolic DD cluster and recruit adaptor proteins (caspases); activates NF-kB

Question 14

Integrins

Answer 14

are focal adhesions and desmosomes; cluster of integrins cause FAKs (protein tyrosin kinases) to phos themselves and allow proteins to bind

Question 15

intracellular receptor (steroids)

Answer 15

HB, pass cell membrane, cholesterol derived, contact intracll receptor once diffused, ACT AS TF

Question 16

nitrous oxide intracell receptor

Answer 16

no receptor; diffuses through membrane and acts quickly and lcoally to make cGMP

Question 17

peptide hormones, Nts and GF extracell receptor

Answer 17

peptide hormones-long life, distant action
NTs-contact post syn cell receptors, HP molecules
neuropeptides-like Nts or hormones

Question 18

Eicosanoids extracell receptor

Answer 18

bind cell surface receptors; are local and short lived
catalyze phospholipids–>arachadonic acid–>prostaglandins through phospholipase A and COX 1/2 respectively
NSAIDS block COX1/2