Cell Receptors Flashcards
Ion Channel coupled Receptors/Ionotropic
fast acting; bind NTs; open and close channels
G-protein coupled receptors
slow; long term effects; intracellular signaling; bind eicosanoids, Nts and peptide hormones; need GTP
Enzyme coupled receptors
are enzymes or are activated by enzymes to perform intracellular signaling
Receptor Tyrosine kinases (RTKs)
phosphorylate intracellular signaling proteins; bind GFs or membrane-bound ligands; are monomers that dimerize, phosphorylate their Tyr residues and activate signaling proteins
Tyrosine Kinase Associated Receptors
bind cytokines, interleukins, integrins; monomers dimerize and activated soluble RTKs at the plasma membrane
Cytokine receptors
bind cytokines and hormones; activate JAK/STAT signaling
Protein tyrosine phosphatases
inhibits signaling pathways by terminating signals; removes P group from phosphotyrosines
Receptor guanylyl cyclase
activates protein kinases, ion channels, and phosphodiesterases; domain stimulated and forms cGMP
Receptor Ser/ Thr Kinase
binds TGF-beta; monomers heterodimerize and one P the other’s Ser/Thr residues; activates Smad pathway
Notch
embryonic development; binds delta; Notch tail cleaved by proteases, Notch translocates to nucleus and acts as TF
Frizzled
binds Wnt; beta-catenin is NOT phos, ubiq, and degraded and is able to translocate to the nucleus and induce transcription
Patched
binds hedgehog; Smoothened prevents cytosolic Ci from being phos, ubiq, and degraded; Cytosolic Ci translocates to the nucleus and acts as a TF
Death Receptors
bind cytokines, GFs and PAMPS; cytosolic DD cluster and recruit adaptor proteins (caspases); activates NF-kB
Integrins
are focal adhesions and desmosomes; cluster of integrins cause FAKs (protein tyrosin kinases) to phos themselves and allow proteins to bind
intracellular receptor (steroids)
HB, pass cell membrane, cholesterol derived, contact intracll receptor once diffused, ACT AS TF
