Cell Surface Markers

Question 1

Natural Killer Cells - Surface Markers

Answer 1

CD16 (Fc binding of IgG)
CD3-
CD56+

Question 2

Lymphoid Progenitor - Surface Markers

Answer 2

CD34+

TdT+

Question 3

Pro-T cells - Surface Markers

Answer 3

CD3+
CD5+ or CD5-
CD7+

Question 4

B-cell - Surface Markers

Answer 4

CD19+
CD20+
CD21+
CD40+
MHCII, B7 (CD80/86)

Question 5

B1 Cell - Surface Markers

Answer 5

CD5+

Question 6

B2 Cell - Surface Markers

Answer 6

CD5-

Question 7

Plasma Cell - Surface Markers

Answer 7

CD19+

IC Light Chain+

Question 8

T Helper cell (all types) - Surface Markers

Answer 8

CD4+
CD40L+(CD154)
CD3+
CXCR4+/CCR5+ (HIV co-receptors)

Question 9

Th17 cell - Surface Markers

Answer 9

CD3+
CD4+
IL-17RA+
RORγ+ - TF

Question 10

Th22 Cell - Surface Markers

Answer 10

CD3+
CD4+
IL-22RA+

Question 11

Th2 Cell - Surface Markers

Answer 11

CD3+
CD4+
GATA3+ - TF
(IL4+, IL5+, IL13+)

Question 12

Th1 Cell - Surface Markers

Answer 12

CD3+
CD4+
T-Bet+ - TF
(IFN-γ+, IL12+, TNF-alpha and TNF-beta +)

Question 13

Treg cell - Surface Markers

Answer 13

CD4+
CD25(high)+
Foxp3+

Question 14

Cytotoxic T cell - Surface Markers

Answer 14

CD8+
CD3+
(CD5+ , CD2+ , CD7+, CD38+)

Question 15

γ-𝛿-T cell - Surface Markers

Answer 15

CD3+
γ𝛿TCR+
CD4-
CD8-

Question 16

T cells (All types) - Surface Markers

Answer 16

TCR
CD3+
CD28+ (Binds to B7 on APC)

Question 17

Macrophages - Surface Markers

Answer 17

CD14+ (for PAMPS)
CD40+
CCR5+
MHCII, B7 (CD80/86)
Fc and C3b receptors (Opsonins)

Question 18

On which cells can we find CD3 Surface Marker?

Answer 18

T cells

Question 19

On which cells can we find CD28 Surface Marker?

Answer 19

T cells, Plasma cells and NK cells

Question 20

On which cells can we find B7 Surface Marker?

Answer 20

APCs: Macrophages, Dendritic cells and B cells.

Question 21

On which cells can we find CD4 Surface Marker?

Answer 21

T Helper cells and T regulatory cells

Question 22

On which cells can we find CD40L (CD154) Surface Marker?

Answer 22

T Helper cells

Question 23

On which cells can we find CXCR4 Surface Marker?

Answer 23

T Helper cells

Question 24

On which cells can we find CCR5 Surface Marker?

Answer 24

T Helper cells and Macrophages

Question 25

On which cells can we find CD8 Surface Marker?

Answer 25

Cytotoxic T cells

Question 26

On which cells can we find CD40 Surface Marker?

Answer 26

T cell -B cell Costimulation (sometimes T+Macrophages) | B cells and Macrophages

Question 27

On which cells can we find CD19, CD20, CD21 Surface Markers?

Answer 27

B cells

Question 28

On which cells can we find CD14 Surface Marker?

Answer 28

Macrophages and Granulocytes

Question 29

On which cells can we find CD80 Surface Marker?

Answer 29

Antigen Presenting Cells DC, B cells and Macrophages (B7)

Question 30

On which cells can we find CD86 Surface Marker?

Answer 30

Antigen Presenting Cells DC, B cells and Macrophages (B7)

Question 31

On which cells can we find CD16 Surface Marker?

Answer 31

NK Cells

Question 32

On which cells can we find CD56 Surface Marker?

Answer 32

NK Cells

Question 33

On which cells can we find CD34 and cKit (CD117)+ Surface Marker?

Answer 33

HSCs

Question 34

HLA-A, HLA-B and HLA-C (HLA-E, F and G as well) | Where are they found?

Answer 34

MHC Class I Subtypes | Meaning all Nucleated cells

Question 35

HLA-DP, HLA-DQ, and HLA-DR (HLA-DM and DO as well) Where are they found?

Answer 35

MHC Class II Subtypes | Meaning all APCs

Question 36

``` Important KIR (Killing Inhibitory Receptor) Example What does it bind? ```

Answer 36

NKG2A | Binds MHC-I

Question 37

``` Important KAR (Killing Activation Receptor) Example What does it bind? ```

Answer 37

NKG2D Binds MICA,MICB and ULBP (Ubiquitous "Stress" Molecules)

Question 38

Immunological Synapse: | CD80/CD86 -(B7s) on DC are interacting with which counterpart on the T cell?

Answer 38

CD28

Question 39

Immunological Synapse: | MHC-II (or I) with Peptide on DC are interacting with which counterparts on the T cell?

Answer 39

TCR+CD3 with CD4 (or CD8 in Cross presentation)

Question 40

Costimulation of B and T cells: 2nd Signal | CD154 (CD40L) on T cell are interacting with which counterparts on the B cell?

Answer 40

CD40

Question 41

Myeloid Progenitor - Markers

Answer 41

CD34+ | MPO+

Question 42

Neutrophills - Surface Marker

Answer 42

CD15+

Question 43

Megakaryocyte- Surface Marker

Answer 43

CD41+