Cytokines Flashcards
(33 cards)
Interleukin - 1 (IL-1)
Secreted By Macrophages
Local: Inflammation Induction
Systemic: Fever, Acute Phase Response.
Endothelium expression of Adhesion molecules.
Induces Chemokine secretion for WBCs recruitment.
Interleukin - 2 (IL-2)
Secreted By T-cells
Proliferation of T cells (Autocrine) and NK cells.
Interleukin - 3 (IL-3)
Secreted By T-cells
Growth Factor: Stimulation of all Leukocytes colony types but Lymphocytes. Like GM-CSF
Interleukin - 6 (IL-6)
Secreted By Macrophages
Causes Fever and Stimulation of Acute Phase Proteins.
Interleukin - 8 (IL-8)
Secreted By Macrophages
“Clean up on aisle 8”
Major Chemokine for Neutrophills ( Basophils and Lymphocytes).
“Clean up on aisle 8” - IL8 for Neutrophills cleaning up infection.
Interleukin - 12 (IL-12)
Secreted By Macrophages
Induces CD4+ T Helper cells to differentiate into TH1.
Activates NK cells.
Tumor Necrosis Factor - TNF-alpha
Secreted By Macrophages
Fever. Activates Endothelium. Causes WBC recruitment, Vascular Leak
Tumor Necrosis Factor - TNF-alpha
Abnormal Pathologic actions (2)
Secreted By Macrophages
In Malignancy - Cachexia
In TB - Maintains Granulomas
Common for IL1, IL6 and TNF-Alpha
Secreted By Macrophages
Mediation of Fever and Sepsis
“Acute Cytokines”
Common for IL8, IL12
Secreted By Macrophages
Cause Recruitment of further WBCs in inflammation for Infection clearance.
Interferon-Gamma
Secreted by? When?
NK cells and TH1 cells in response to Antigen or IL-12 from Macrophages.
Interferon-Gamma Stimulates _____ to kill phagocytosed Pathogen.
Interferon-Gamma Stimulates Macrophages to kill phagocytosed Pathogen.
Interferon-Gamma: Inhibits differentiation of ___ cells
Interferon-Gamma: Inhibits differentiation of TH2 cells
Interferon-Gamma: Activates ___ cells to kill _____ cells.
Interferon-Gamma: Activates NK cells to kill Virus-Infected cells.
Interferon-Gamma: Increases ___ expression and antigen presentation in ___ cells.
Interferon-Gamma: Increases MHC expression and antigen presentation in All cells.
Interleukin - 4 (IL-4)
Secreted from ___ cells and Causes T cells differentiate to ___ cells.
Interleukin - 4 (IL1-4)
Secreted from TH2 cells and Causes T cells differentiate to TH2 cells.
Interleukin - 4 (IL-4) Promotes growth of \_\_\_ cells. Enhances class switching to \_\_\_ and \_\_\_ .
Interleukin - 4 (IL1-4) Promotes growth of B cells. Enhances class switching to IgE and IgG.
Interleukin - 5 (IL-5)
Secreted by ___, Promotes growth and differentiation of ___ cells and ___phils.
Interleukin - 5 (IL1-5)
Secreted by TH2, Promotes growth and differentiation of B cells Eosinophils.
Interleukin - 5 (IL-5) Enhances class switching to \_\_\_ .
Interleukin - 5 (IL1-5) Enhances class switching to IgA .
Interleukin - 10 (IL-10)
Secreted by ___ cells - ___ Inflammatory Response.
Same action as ___ .
Interleukin - 10 (IL1-10)
Secreted by TH2 cells - Attenuates Inflammatory Response. Same action as TGF-beta.
Interleukin - 10 (IL-10)
Secreted by ___ cells - Decreases expression of _____ and ___ Cytokines.
Interleukin - 10 (IL1-10)
Secreted by TH2 cells - Decreases expression of MHCII and TH1 Cytokines.
Interleukin - 10 (IL-10)
Secreted by ___ cells and also by ___
Interleukin - 10 (IL1-10)
Secreted by TH2 cells and also by T regulatory cells.
Interleukin - 10 (IL-10)
Inhibits ___ and ___ cells.
Interleukin - 10 (IL1-10)
Inhibits Macrophages and Dendritic cells.
Common for IL-4, IL-5 and IL-10
IL4,IL5 and IL10 are secreted by TH2 cells.
