Cerebellopontine Angle Lesions Flashcards
Where is the cerebellopontine angle?
Between cerebellum and pons
What is found in the cerebellopontine angle?
Anterior inferior cerebellar artery
CN VIII
CN VII
Lateral recess of fourth ventricle
What can affect the cerebellopontine angle?
Acoustic neuroma
What is an acoustic neuroma also known as?
Vestibular schwannoma
What is an acoustic neuroma?
Tumour of schwann cells surrounding CNVIII
What condition are bilateral acoustic neuromas associated with?
Neurofibromatosis 2
What is neurofibromatosis?
Genetic condition that causes benign neuromas to develop throughout the body
What are the types of neurofibromatosis?
Type 1
Type 2
What gene is associated with NF1?
NF1 gene on chromosome 17
Codes for neurofibromin which is a tumour suppressor protein
What is the inheritance pattern of NF1?
Autosomal dominant
What are the criteria for NF1?
2 out of 7 needed
Cafe-au-lait spots Relative with NF1 Axillary/inguinal freckles Bony dysplasia Iris hamartomas (yellow spots on iris) Neurofibromas Glioma of optic nerve
What gene is associated with NF2?
NF2 gene on chromosome 22
Codes for merlin - a tumour suppressor protein particularly important for Schwann cells
What is the inheritance pattern of NF2?
Autosomal dominant
What are features of NF2?
Acoustic neuromas
Schwannomas
What are features of acoustic neuromas?
Vertigo Hearing loss Tinnitus Absent corneal reflex Facial palsy
