Epilepsy Flashcards

(40 cards)

1
Q

What is a seizure?

A

Sudden irregular discharge of electrical activity in the brain causing a physical manifestation

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2
Q

What is a convulsion?

A

Uncontrolled shaking movements of the body due to rapid and repeated contraction and relaxation of muscles

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3
Q

What is an aura?

A

A perceptual disturbance experienced

e. g
- strange light
- unpleasant smell
- confusing thoughts

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4
Q

What is epilepsy?

A

Neurological disorder marked by sudden recurrent episodes of sensory disturbance, LOC or convulsions, associated with abnormal electrical activity in the brain

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5
Q

What is status epilepticus?

A

Epileptic seizures occurring continuously without recovery of consciousness between

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6
Q

How are seizures classified?

A

Partial

General

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7
Q

How are partial seizures further classified?

A

Simple

Complex

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8
Q

How are general seizures further classified?

A
Absence
Myoclonic 
Tonic-clonic 
Tonic 
Atonic
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9
Q

What is a partial seizure?

A

Seizure with a single focus

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10
Q

What is a generalised seizure?

A

Seizure spread uncontrolled throughout brain

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11
Q

What is a simple partial seizure?

A

No loss of consciousness

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12
Q

What is a complex partial seizure?

A

Loss of consciousness

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13
Q

What are common types of partial seizures?

A

Temporal lobe epilepsy

Frontal lobe epilepsy

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14
Q

What are the features of temporal lobe epilepsy?

A

Hallucinations
Automatisms
Rush of memories

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15
Q

What are features of frontal lobe epilepsy?

A

Head/leg movements
Posturing
Post-ictal weakness

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16
Q

What is a tonic-clonic seizure?

A

2 parts

  • muscles tense
  • convulsions
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17
Q

What is an absence seizure?

A

Loss of awareness

‘daydreaming’

18
Q

What is a myoclonic seizure?

A

Brief shock-like muscle jerks

19
Q

What is an atonic seizure?

A

Loss of tone

‘Drop attacks’

20
Q

What is a tonic seizure?

A

Increased tone

21
Q

What are other features of tonic-clonic seizures?

A

Pre-seizure aura

Tongue biting
Incontinence

Prolonged post ictal phase

22
Q

How are seizures investigated?

A

EEG
MRI brain

ECG
Bloods 
- FBC
- U&Es
- calcium
23
Q

How are single seizures managed?

A

Confirm diagnosis
Establish cause
Discuss implications

24
Q

How is the diagnosis of epilepsy made?

A

> 2 seizures in >24 hours

25
How are generalised seizures managed?
Sodium valproate Lamotrigine Phenytoin
26
How are complex partial seizures managed?
Carbamazepine Lamotrigine Levetiracetam
27
What is the mechanism of sodium valproate?
Increases GABA activity
28
What are side effects of sodium valproate?
Liver damage Hair loss Tremor Lowers vit D - needs regular monitoring Teratogenic - women of child bearing age need 2 forms of contraception
29
What is the mechanism of lamotrigine?
Sodium channel blocker
30
What are the side effects of lamotrigine?
SJS | Leucopenia
31
What is the mechanism of phenyotin?
Sodium channel blocker
32
What are the side effects of phenytoin?
Folate deficiency Vit D deficiency Megaloblastic anaemia Osteomalacia
33
What is the mechanism of carbamazepine?
Sodium channel blocker
34
What are the side effects of carbamazepine?
Agranulocytosis Aplastic anaemia P450 inducer
35
What is the mechanism of levetiracetam?
Blocks pre-synaptic calcium release
36
What are the side effects of levetiracetam?
Headache Drowsiness SJS
37
What are the driving rules for a single unprovoked seizure with normal brain imaging and EEG?
6 months off
38
What are the driving rules for a single unprovoked seizure with an abnormality detected?
12 months off
39
What are the driving rules for confirmed epilepsy?
12 months seizure free
40
What are the driving rules for epilepsy medication withdrawal?
Do not drive during withdrawal and for 6 months after