cerebullum Flashcards

(46 cards)

1
Q

What is the embryologic origin of the cerebellum?

A

Alar plate of the embryonic metencephalon

The cerebellum forms the roof of the 4th ventricle.

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2
Q

Name the four main divisions of the cerebellum.

A
  • Vermis
  • Paravermal zones
  • Hemispheres
  • flocculonodular lobe: flocculus = lateral nodulus = midline of vermis)

The flocculonodular lobe is also a significant part of the cerebellum.

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3
Q

Which cerebellar peduncle is primarily afferent? (cerebrum - medulla)

A

Caudal cerebellar peduncle

input from spinal cord and vestibular

It receives input from the spinal cord and vestibular system.

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4
Q

What is the appearance of the white matter core of the cerebellum?

A

Arbor Vitae

It has a tree-like appearance surrounded by grey matter cortex.

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5
Q

What are the three layers of the cerebellar cortex?

A
  • Molecular layer
  • Purkinje cell layer
  • Granule cell layer
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6
Q

What type of fibers originate from the olivary nucleus?

A

Climbing fibers

They provide profound excitation of Purkinje cells and are involved in motor learning.

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7
Q

What is the primary function and input of the flocculonodular lobe?

A

Equilibrium & vestibular reflex coordination.

input: vestibular system

It receives input from the vestibular system.

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8
Q

True or False: The cerebellum initiates movement.

A

False

no conscious8 sensory perception

The cerebellum modulates movement but does not initiate it.

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9
Q

What is motor ataxia?

A

Exaggerated, uncoordinated movement

It differs from proprioceptive ataxia as it does not involve paresis.

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10
Q

Which tract carries proprioceptive information from the hindlimbs?

A

Dorsal spinocerebellar tract (DSCT)

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11
Q

What signs may indicate a lesion in the flocculonodular lobe?

A
  • Broad stance
  • Falling
  • Nystagmus
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12
Q

What is an intention tremor?

A

Tremors seen during movement, not at rest

Head tremors may often be observed during eating or drinking.

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13
Q

Fill in the blank: The cerebellum does not have direct influence on _______.

A

lower motor neurons

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14
Q

What is cerebellar hypoplasia commonly caused by in kittens?

A

Feline panleukopenia virus infection during gestation

This condition results in fewer granule cells and static cerebellar ataxia.

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15
Q

What is the major output from the cerebellum? (cerebellum - midbrain)

A

Rostral cerebellar peduncle

It contains mostly efferent fibers.

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16
Q

What is the function and input of the vermis and paravermal zones?

A

Posture, muscle tone, coordination

input: spinocerebellar tracts

They receive input from the spinocerebellar tracts.

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17
Q

Which spinocerebellar tract carries information from the forelimbs?

A

Cuneocerebellar tract (CCT)

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18
Q

True or False: Cerebellar signs are typically contralateral to the lesion.

A

False

Cerebellar signs are usually ipsilateral to the lesion.

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19
Q

How does the cerebellar cortex influence motor systems?

A

Inhibits deep cerebellar nuclei

This inhibition provides a tonic excitatory output.

20
Q

What is hypermetria?

A

Excessive limb movement, ‘high stepping’

It is a sign of cerebellar dysfunction.

21
Q

What are the signs of delayed voluntary movements indicative of?

A

Lateral hemisphere lesions

22
Q

what is the major input for the cerebellum? (ENTIRELY afferent) (cerebellum - pons)

A

Middle cerebellar peduncle.

input from pontine nuclei

23
Q

3 deep cerebellar nuclei of arbor vitae

A

fastigial (medial

interposed

lateral (dentate)

24
Q

molecular layer of cerebellum

A

most superficial

purkinje DEDRITES, granule axons, interneurons

25
purkinje layer of cerebellum
middle layer large GABAergic neurons; inhibitory output to deep nuclei
26
Granule layer fo cerebellum
deepest layer small, excitatory neurons (dense nuclei)
27
what type of fibers originate at the vestibular nuclei, sprinocerebllar and trigeminocerebellar tracts?
mossy fibers
28
mossy fibers
majority of input to granule cells
29
climbing fibers
profound excitation of purkinje cells --> motor learning
30
3 main functions of the cerebellum
Rate Range Force - of voluntary movement
31
What is the function and input of the lateral hemispheres?
planning/timing of skilled voluntary movement input: motor cortices (via pontine nuclei)
32
functional connections of the spinocerebellar tract
bring unconscious proprioception
33
functional connection of cerebellar cortex (purkinje cells)
inhibit deep cerebellar nuclei
34
functional connection of the deep cerebellar nuclei
tonic excitatory output --> influences motor systems
35
what are the 4 major cerebellar pathways - ALL ARE IPSILATERAL (name, info origin, peduncle USED, note)
DSCT - hindlimbs - caudal - nucleus thoracis, AKA clarke's column VSCT - hindlimbs - rostral - ENTERS at rostral peduncle CCT - forelimbs - caudal - synapse in lateral cuneate nucelus RSCT - forelimbs - rostral and caudal - ENTERS via BOTH peduncles
36
cerebellar signs are typically __________ to the lesion
ipsilateral
37
signs of cerebellar disease
gait and posture abnormalities (hypermetria) delayed and exaggerated postural reactions normal strength Vestibular signs: broad stance, falling, nystagmus intention tremors truncal sway pendular nystagmus - fluttering eyes w/out fast and slow phase absent menace response (W/ normal vision and facial function)
37
what cerebellar cell layer contains inhibitory output neurons
purkinje cell layer
38
what disease in cats causes cerebellar hypoplasia
Feline panleukopenia virus
39
which cerebellar peduncle contains mostly efferent fibers?
rostral cerebellar peduncle
40
what is motor ataxia and how is it different from proprioceptive ataxia?
uncoordinated movement without paresis or proprioceptive loss
41
what tract carries info from the hindlimbs?
DSCT
42
what cerebellar lesion may cause paradoxical vestibular signs?
flocculonodular lobe lesion
43
what spinocerebellar tract crosses twice?
VSCT
44
a cerebellar patient has a fast-phase nystagmus TOWARDS the lesion. what is it called?
paradoxical vestibular syndrome
45
cerebellar signs are usually ipsilateral because...
spinocerebellar tracts are ipsilateral