Cervix Flashcards Preview

Ch. 13 Female Genital and Gestation > Cervix > Flashcards

Flashcards in Cervix Deck (17):
1

Condyloma HPV strains

6, 11

2

High-risk HPV strains

16, 18, 31, 33

3

High risk HPV types make these protein virulence factors

E6: destroys p53
E7: destroys Rb

4

Epithelium in
external cervix
internal cervix

external: stratified squamous
internal: columnar
transformation zone is in between

5

Most HPV infections happen where in cervix

transition zone

6

CIN I
CIN II
CIN III

cervical intraepithelial neoplasia (dysplasias until carcinoma)
CIN I:

7

What differentiates dysplasia and carcinoma

carcinoma is irreversible
dysplasia is reversible

8

Cervical carcinoma presentation

vaginal bleeding
postcoital bleeding

9

Other non-HPV risk factors for cervical carcinoma

smoking
immunodeficiency (AIDS-defining)

10

What does it mean to be an AIDS-defining illness

if person has these then they have clinically AIDS patients and not HIV patients

11

Invasion of cervical cancer

metastisizes late
aggressive local invasion
bladder --> block ureters --> hydronephrosis --> renal failure

12

Types of cervical cancer

squamous cell
adenocarcinoma

13

What type of cervical cancer do paps pick up

squamous cell
they follow dysplasia --> carcinoma sequence
adenocarcinoma does not follow this pathway so it is not easily detected

14

HPV causes what subtypes of cervical cancer

both squamous and adenocarcinoma

15

How long does it take for dysplasia to move into carcinoma in cervical cancer

10-20 yr

16

How did the cervix get its name

cervix = neck
like cervical spine = that's the real neck
purty neat

17

Confirmatory test for abnormal pap

Bx