Ch 32 - CNS Cancer Flashcards

(92 cards)

1
Q

The spinal cord is the continuation of the ________.

A

Medulla oblongata

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2
Q

Anterior and lateral portion of the spinal cord contains _______ and _____

A

Motor neurons and tracts

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3
Q

The posterior portion of the spinal cord contains _______

A

Sensory tracts

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4
Q

Blood supply of the brain comes from ________ and ________ via the Circle of Willis

A

From the internal carotid arteries and vertebral arteries

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5
Q

Gray matter is composed of

A

Supportive nerve cell bodies

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6
Q

White matter is composed of bundles of

A

myleinated nerve fibers,

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7
Q

Axons carries impulses _______ from the cell body

A

Away

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8
Q

Dendrites carries impulses _______ the cell body

A

Towards

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9
Q

Spinal cord extends to what vertebral body

A

Spinal cord extends to L1/L2

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10
Q

Spinal canal consist of

A

CSF- cerebral spinal fluid

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11
Q

The blood Brain barrier protect the brain from

A

Potentially harmful substances and hinders the penetration of some substances into the brain and CSF

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12
Q

BBB limited our treatment because

A

There’s small spaces where molecules in the blood cannot get into the different channels in the brain tissues

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13
Q

In order for substances to pass through the BBB they must be _____

A

Lipid soluble which includes alcohol, nicotine, and heroin

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14
Q

Water soluble substances needs _______ to cross the BBB via ______

A

Carrier molecule via active transport

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15
Q

Most CNS tumors are what kind

A

Metastatic tumors

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16
Q

The treatment of choice for PRIMARY brain tumor is

A

Surgery

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17
Q

Metastatic tumors to the brain usually originate in the

A

Lungs

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18
Q

What is not consider as the 3 important prognostic indicators for CNS tumors

A

The size

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19
Q

What are the 3 important prognostic indicators for CNS tumors

A

Type and grade of tumor
Age
Karnofsky score

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20
Q

T/F

Primary CNS tumors occur more often in the spine than in the brain

A

False

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21
Q

Brain tumors typically spread by the way of

A

Direct extension

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22
Q

Why would a benign tumor be considered malignant

A

Due to its location and its close proximity to other structures

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23
Q

SRS is indicated for metastatic lesions that is larger than

A

3cm

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24
Q

What is the TD5/5 for partial brain irradiation

A

6000cGy (60Gy)

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25
What is the TD5/5 for whole brain
5000cGy (50Gy)
26
What is the TD5/5 for spinal
4500-5000 (45-50Gy)
27
What is the most common malignant CNS pediatric tumor
Medulloblastoma
28
Which part of the brain is the center for memory, learning, reasoning, judgement, intelligence and emotions
Cerebrum
29
SRS is thought to be accurate within
1mm
30
At what dose can hair lose become permanent
Greater than 4000 (40Gy)
31
At what dose is hair loss temporary
Between 2000-4000cGy (20-40Gy)
32
What would you recommend a patient wash their hair with while on treatment for a brain tumor
A mild shampoo (baby shampoo)
33
How much CSF circulates within the CNS
3-5 ounces
34
Only these types can pass through the BBB
Lipid soluble
35
Brain tumors occur most often in people ages
Pediatric (3-12yrs) | Geriatrics ( 50-80yrs)
36
What is the term for the structure in the brain that is Latin for little brain"
Cerebellum
37
Patients that are unable to work fall nto what range of the karnofsky scale
40-70
38
What is the TD5/5 for the lens of the eyes
10Gy
39
What is the TD5/5 for the optic chiasm
50Gy
40
Which of the following does NOT provide protection for the brain
Cerebellum
41
A gliomas spreads primarily by the way of ...
Local invasion (direct extension)
42
The BBB protects...
The brain from potentially toxic substances But not heroine or alcohol
43
Weakened proximal pelvic muscle, impotence, and bladder paralysis might indicate a signal tumor in what region
Limbo sacral
44
What is the current 5 yr survival of patients with PRIMARY CNS tumor
35%
45
What type of tumor is classified by primitive neuroectodermal cell
Medulloblastoma
46
What is the most common type of brain tumor
Metastatic lesions
47
Where do most brain mets originate from
Lungs
48
Which cell is responsible for myelin production
Schwann cells
49
What factors can limit the usefulness of surgery for CNS neoplasm
Tumor location an extent Patient status Risk of neurological damage
50
Which portion of the brain is the site for intelligence and judgement
Cerebrum
51
What condition is a contradiction for SRS
5 lesions
52
What is one of the late effects of brain radiation in children
Decreased IQ
53
Which of the following is the most significant to the prognosis of brain tumors
Tumor grade
54
Which of the following Beam arrangements is most typical for treatment of a malignant malignant primary brain tumors
Small field with 1-3cm margins
55
What is the dose at which radiation necrosis of brain tissue is most likely to occur
6000cGy (60Gy)
56
Epilation may be permanent when the cranial is treated beyond the threshold dose of ____ cGy
Beyond 4000cGy
57
Patients treated to the cranial should be advised to protect their heads from direct sunlight because the sun
Enhances radiation induced side effects
58
These are small round blue cells that become CNS malignancies
Primitive neuroectodermal cells
59
Medullolastoma mostly Present in the
Cerebellum
60
What's the 3 yr survival rate for GBM is roughly
2%
61
How much cerebral spinal fluid (CSF) is secreted each day
Half liter (0.5L)
62
A fold of tissue that separates the brain hemisphere and the cerebrum from the cerebellum is the ....
Tentorium
63
Brain tumors are the ____ leading cause of death in children
Second and is the most common pediatric solid tumor
64
Function of this portion of the brain is coordination of voluntary muscular movement and is known as the little brain
Cerebellum
65
75% of all CNS tumors occur in the
Cerebrum
66
Gliomas of pediatrics occur in the
Cerebellum
67
Of the 3 prognostic indicator, __________ is the primary prognostic indicator for CNS tumors
Tumor grade associated with tumor type
68
The brain is protected by
Cranial bones Meninges CSF
69
For the brain: ____ matter is located on the outside, forms the cortex and have supportive nerve cells. _____ after is on the inside and contains bundles of myelinated fibers that sends and receives signals
Gray Outside | White Inside
70
For the spinal cord: | ___ matter is on the outside while ____ matter is on the inside
White Outside | Gray Insides
71
The spinal cord extends to what level
L1-L2
72
What is aphasia
Difficulty speaking
73
What is hemiplegia
Paralysis on one side of the body
74
What is paresis
Weakening of the muscles
75
Symptoms for frontal tumor
Personality changes Memory loss Gait disorder Speech changes
76
Symptom for parietal tumors
Loss of vision Spatial disorientation Seizures
77
Symptoms for occipital tumors
Loss of sight
78
Symptoms for temporal tumors
Hearing and smelling changes | Hallucinations
79
The _____ area is the most frequent site for spinal tumor seeding
Lumbosacral
80
Presentation for spinal cord tumor
Pain Weakness Loss of sensation Weakness in distal part of extremity
81
When _____ is present, whole brain treatment is given
Metastatic disease
82
Most common site in the brain for brain mets
Cortex
83
Whole brain technique is used to treat
Brain mets | Lymphoma
84
What is the typical dose to treat whole brain
20-40Gy
85
The Treated Volume (TV) is the volume enclosed by the desired prescription isodose and contains...
GTV, CTV, PTV
86
The Irradiated volume (IR) is the tissue volume that receive significant dose and contains...
GTV, CTV, PTV and TV
87
The CTV is ______ cm beyond the GTV
1-3cm beyond the GTV
88
The PTV is ____cm beyond the CTV
0.5cm-1cm beyond the CTV
89
TD5/5 for spinal cord
47Gy
90
TD5/5 for ear
30-55Gy
91
Td5/5 for brain stem
50Gy
92
SRS are done on tumors that are
Spherical LESS than 5cm Accuracy occurs to 1mm