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IHP 1001 > Ch.6 Connective Tissue > Flashcards

Ch.6 Connective Tissue Flashcards

(51 cards)

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1
Q

Comprises a diverse group of cells within a tissue-specific extracellular matrix

A

connecitve tissue

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2
Q

?

A

Connective Tissue

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3
Q

Connecitve tissue consist of cells within?

A

Cell within the ECM

Contains protein fibers & ground substance

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4
Q

3 classifications of connecitve tissue?

A
  1. Embryonic
  2. Connecitve tissue proper
  3. Specialized
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5
Q
  • Mesenchyme
  • Mucous Connective Tissue
A

Embryoni connecitve tissue

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6
Q
  • Loose Connective Tissue
  • Dense Connective Tissue
A

Connective tissue proper

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7
Q
  • Cartilage
  • Bone
  • Adipose Tissue
  • Blood
  • Hemopoietic Tissue
  • Lymphatic Tissue
A

specialized connecitve tissue

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8
Q
  • Derived from the mesoderm
  • Found in the embryo
  • Extracellular space occupied by viscous grpup substance with limited collagen fibers
A

Mesenchyme

E, con, tissue

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9
Q
  • Present in umbilical cord
  • Ground substance known as wharton’s jelly
A

Mucous Connective tissue

E, con, tissue

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10
Q

2 types of conencitve tissue proper?

A
  1. Loose connecitve tissue (areolar)
  2. Dense Connecitve tissue (regular & iregular
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11
Q

?

A

Loose Connective tissue

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12
Q
  • Thin, relatively sparse collagen fibers
  • Abundant ground substance
  • Primarily located beneath epithelia
A

Loose connective tissue

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13
Q

where do sites of inflammation and swelling occur? significant swelling

A

Loose connective tissue

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14
Q
  • Contains mostly collagen fibers
  • Cells are sparse and * typically fibroblasts
  • Very little ground substance
  • Strong tissue, allows organs to resist excessive stretching and distention.
A

Dense connective tissue

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15
Q

Example of Dense connecitve tissue?

A

Reticular layer of dermis

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16
Q

Dense connecitve tissue

Ordered and densely packed arrays ____ with cells (tendioncytes) aligned between fiber bundles.

A

collagen fibers

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17
Q

Dense connective tissue is a functional component of what? (4)

A
  1. Tendons
  2. Ligaments
  3. Aponeuroses
  4. PDL
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18
Q

3 types of connecitve tissue fibers?

A
  1. Collagen
  2. Reticular
  3. Elastic
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19
Q
  • Most abudant component of connecitve tissye
  • Flexible high tensile strength
A

Collagen Fibers

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20
Q

What subunits make up collagen fibers?

A

collgen fibrils
* 68nm banding patter
* Gap

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21
Q

explain structure of collagen

Study These Flashcards
A
  • Triple helic of 3 polypeptide chains
22
Q

What is the main collagen in the body?

Study These Flashcards
A

Type I

30 diffrent kinds

23
Q

In collagen biosyntheisis, what occurs

Study These Flashcards
A

Proline and lysine hydroxylation

24
Q

What is the cofactor required for hydroxylation of prolien and lysine for collagen biosynthesis

Study These Flashcards
A

Ascorbic acid (VitC)

25
Where are procollagen molecules formed?
Within fibroblasts
26
**Procollagen fibers** are ceaved into ____ which are **assemebled into larger collegen fiber** outside in the ECM
Procollagen cleaved into **fibrils**
27
28
# Collagenopathies * **Type I collagen** * Brittle bones, **abnormal teeth,** thin skin, weak tendons, progressive hearing loss
Osteogenisis imperfecta
29
# Collagenopathies * **Type 3 Collagen** * Hypermobility of all joints, finger joint deformities
Ehlers-Danlos, type 3
30
# Collagenopathies * **Type 3 collagen** * Pale, translucent, thin skin * Also known as vascular ____
Ehlers-Danlos syndrome type 4
31
Type V collagenopathy
Classical Ehlers-Danlos
32
* Provide a **supporting framewor**k for the cellular components of tissues and organs * Composed of **Type III collagen** * Named for their *mesh-like arrangement*
Reticular FIbers
33
What type of connecitve tissue fibers a re **prominantn in the initial stages of wound healing and scar formation?**
Reticular fibers
34
# What connective tissue fiber? Abundant in lymphatic tissues
Reticular Fibers
35
* Allow tissues to respond to **stretch and distension** * **Thinner** than collagen fibers and **1000x more flexible** then collagen * Arranged in a 3D network cross linked **elastin molecules assc.** Network of fibrillin microfibrils.
Elastic fibers
36
What 4 cells produce elastic fibers?
1. Fibroblasts 2. Chondrocytes 3. Endothelial cells 4. Smooth muscle cells
37
What is responsisble for eslatic property of elastic fibers?
Polypetide makeup resulting in random coiling, hydrophobic alternate with hydrophillic
38
The unique amino acids **desmosine and isodesmosine** are responsible for what in elastic fibers?
**Covalent boding of elastin molecules to others**
39
which fibers contain **NO Hydroxylysine?**
Elastic fibers
40
* Mutated elastin forms**thinner elastic fibers** and **disorganized elastic lamellae** in the wall of the **ascending aorta** * Results in increased production of smooth muscle in aorta that causes **stenosis of the artery**
Supravascular aortic stenosis (SVAS)
41
* Characterized by wrinkled, redundant, sagging **inelastic skin** * Defective dermal elastic fiber synthesis
Cutis Laxa
42
# What kind of cells? * Fibroblasts and Myofibroblasts * Macrophages * Adipocytes * Mast cells * Adult stem cells
Resident Connecitve tissue cells
43
# What kind of cells? * Lymphocytes * Plasma Cells * Neutrophils * Eosinophils * Basophils * Monocytes
Wandering transient connecitve tissue cells
44
* Synthesize of **collagen, elastic and reticular fibers** * Produce the **complex carbohydrates of ground substance**
Fibroblasts and Myofibroblasts | Residents
45
What cells similar to fibroblast are involved in wound healing by **contracting edges of the wound**?
Myofibroblasts | Resudent
46
* Palmar fibromatosis * Characterized by the **thickening of the palmar aponeurosis** * Increase flexion of the 4th and 5th digits of the hand
Dupartrens disease | do pardon my languange.. LOL
47
* **Phagocytic cells** derived from monocytes * **APCs **due to the presence of **MHC II)** molecules on their cell membrane * **Promote inflammation** and apotosis
Macrophages | Resident
48
Macrophages can from ____ cells, large cells 100 macrophages fused
Langerhan Cells
49
* Key role in inflammation **(degranulates cell)** * Allergy and **anaphylaxis** * Important for wound healing because they**stimulate angiogenesis**
Mast Cells | Resident
50
Connective tissue cell which is specialized for**storage of fat and production of hormones**
Adipocytes | Resident
51
resident in niches, dif to distinguish
Adult stem cells | Resident

IHP 1001 (18 decks)

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