Flashcards in Chap 2 Part 1 Deck (56)
Unlike epithelium, connective tissue consists mostly of what?
intercellular components and a limited number of cells
What are the 4 main functions of CT?
structral support, medium for exchange, defense/protection, and storage of adipose
What are the 4 main characteristics of CT?
derived from mesenchyme, support cells separated by matrix, support cells produce matrix, and cells adhere to matrix
What are the main components of the ground substance of extracellular matrix?
glycosaminoglycans, proteoglycans, adhesive glycoproteins, and other.
Which are larger, sulfated or non-sulfated GAGs
non-sulfated GAGs are larger molecules
Which type of GAGs are covalently bonded to proteins?
Which type of GAGs is important for allowing diffusion in some tissues as it holds a lot of water?
What are the main two positive aspects of inflammation?
increased fluidity will aid cell movement and increases numbers of defensive cells
What is the main negative aspect of inflammation?
excessive swelling can damage blood vessels, nerves, and cells
What is the term for a protein core with many sulfated GAGs attached?
What kind of fibers are associated with CT?
reticular, elastic and collagen
What is the most common CT protein?
Wich type of collagen accounts for about 90% of the total body collagen?
Type I collagen
Which type of collagen is known for great tensile strength but does not stretch?
T/F: As aging increases, fiber production slows and the fibers produced are stronger.
False; production slows but fibers produced are weaker (Ehlers-Danlos syndrome)
Which vitamin deficit is associated with weaker collagen I, bruising and bleeding gums?
Vitamin C (scurvy)
Which type of fiber can stretch 150% of its resting length?
Which type of fiber is important in blood vessels and lungs, commonly produced by fibroblasts and smooth muscle cells, and generally has fewer pathologies associated with it?
As age increases, what happens to the number of elastic fibers?
What condition is a hereditary condition of CT, bones, muscles, ligaments and skeletal structures and is characterized by undeveloped elastic fibers?
T/F: Marfan's Syndrome can lead to aortic aneurysm.
Which type of fiber lasts for about 3 days, is not affected by age, and is the first fiber produced during wound healing?
What are the 7 different cells in CT?
fibroblasts, fibrocytes, myofibroblast, adipocytes, plasma cells, macrophages, and mast cells
Where are fibroblasts usually derived from?
When do fibroblasts primarily divide?
What are the 3 main structural functions of fibroblasts?
produce/maintain matrix, produce growth factors, and scar formation
What are the main defensive functions of fibroblasts?
produce cytokines and enzymes and they can phagocytize when it is really needed.
T/F: Fibrocytes appear flatter than fibroblasts?
T/F: Fibrocytes can produce collagen I fibers and elastic fibers.
False; cannot produce either