Chapter 12 Flashcards
(69 cards)
How are serum pH and serum potassium related?
Acidaemia increases serum potassium (potassium shifts extracellularly)
Alkalaemia decreases serum potassium (potassium shifts intracellularly)
What is the most common electrolyte disorder which causes cardiac arrest?
Hyperkalaemia
Causes of hyperkalaemia
Renal failure
Drugs e.g. ACEi, ARB, potassium-sparing diuretics
Tissue breakdown e.g rhabdo
Metabolic acidosis e.g. DKA
Endocrine disorders e.g. Addison’s
Diet
Signs/symptoms of hyperkalaemia
Flaccid paralysis
Paraesthesia
Depressed deep tendon reflexes
ECG abnormalities in hyperkalaemia
Prolonged PR
Flat/absent P waves
Peaked T waves
ST depression
S and T wave merging
Wide QRS
VT
Brady
Management of hyperkalaemia in patients not in cardiac arrest
A-E assessment
12-lead ECG
Mild (5.5-5.9) - avoid further elevation (drugs etc.), calcium resonium/sodium zirconium (binds potassium). Onset of binders >4 hours.
Moderate (6.0-6.4) - insulin/dextrose (10 units insulin and 25g glucose over 15-30 minutes), futher IV glucose if pre-treatment BM less than 7, potassium binders
Severe (over 6.4) -
Without ECG changes - insulin/dextrose, give salbutamol (10-20mg), potassium binders. Consider cardiac monitoring.
With ECG changes - give calcium salts (calcium gluconate), insulin/dextrose, salbutamol, potassium binders, continuous cardiac monitoring.
Consider dialysis if refractory
How to manage hyperkalaemia in cardiac arrest
Give calcium chloride 10% 10ml, insulin/dextrose, sodium bicarbonate 50ml 8.4% by rapid injection if severe acidosis or renal failure
Consider dialysis
Definition of hypokalaemia
Serum potassium below 3.5, severe below 2.5
Causes of hypokalaemia
GI loss
Diuretics - loop/thiazide
Treated DKA
Endocrine disorders e.g. Cushing’s
Renal losses e.g. DI, dialysis
Magnesium depletion
Poor dietary intake
ECG features hypokalaemia
U waves
T wave flattening
ST segment changes
Arrhythmias
How is hypokalaemia managed?
Potassium infusion. Maximum recommended dose is 20mmol/hour but more rapid infusion given if arrhythmia with risk of imminent cardiac arrest.
Continuous cardiac monitoring required.
Often need magnesium replacement.
Rate of cardiac arrest in dialysis patients
High risk for cardiac arrest, occurs up to 20x more frequently than general population. Survival to discharge comparable.
Management of cardiac arrest in dialysis patients
Dialysis nurse should operate haemodialysis machine
Stop dialysis, replace blood volume with fluid bolus
Disconnect from dialysis machine
Use dialysis access for drug administration
May require early dialysis post-resuscitation
Manage hyperkalaemia
Sepsis definition and associated mortality
Life-threatening organ dysfunction caused by dysregulated host response to infection.
SOFA score 2 or more reflects overall mortality risk of 10%
Septic shock - requiring vasopressors to maintain MAP 65 or more or lactate over 2 despite adequate fluid resuscitation
Septic shock has 40% mortality
How should sepsis be managed in cardiac arrest?
Fluid resuscitation
Broad spectrum antibiotics
Serum lactate
Measure urine output
Take blood cultures
Give high-flow oxygen target sats 94-98%
Modifications to resuscitation in poisoning
Wear PPE
Avoid mouth-to-mouth in chemicals such as cyanide, hydrogen sulphide, corrosives and organophosphates
Treat tachyarrhythmias with cardioversion
Correct glucose, electrolytes and acid-base disorders
Once resus started try to identify toxin - history from family/paramedics, clinical examination for toxidrome
Monitor temperature
May need prolonged resus as toxin metabolised/excreted - consider extracorporeal life support
Consult toxbase for specific treatment
Use of activated charcoal in toxin ingestion
Can consider single dose in ingestion of toxin known to be adsorbed by activated charcoal
Ensure intact or protected airway
Can give multiple doses if carbemazepine, dapsone, phenobarbital, quinine or theophylline
Management of opioid overdose
Naloxone if respiratory compromise
Naloxine - 400mcg IV, 800mcg IM, 800mcg SC or 2mg intranasally
Titrate dose to effect
May require ongoing infusion
Management of benzodiazepine overdose
Flumazenil
Significant risk of withdrawals, seizures, arrhythmia, hypotension if used in benzo dependent patients
Management of tricyclic antidepressant overdose
Can cause VT
Sodium bicarbonate if broad QRS
pH target 7.45-7.55
Management of cardiac arrest due to local anaesthetic toxicity
Consider IV 20% lipid emulsion infusion. Initially 1.5ml/kg then 15ml/kg/hour up to maximum 12ml/kg
Management of stimulant overdose
Small doses IV benzos
Nitrates for myocardial ischaemia secondary to cocaine
Management of drug induced severe bradycardia
Atropine for organophosphate, carbamate or nerve agent poisoning - may require big doses
Isoprenaline for beta-blockers
May require transcutaneous pacing
Most common causes of death due to asthma
Severe bronchospasm leading to asphyxia
Cardiac arrhythmias caused by hypoxia
Dynamic hyperinflation in mechanically ventilated patients which reduces venous return and blood pressure
Tension pneumothorax