Chapter 12 Flashcards

(69 cards)

1
Q

How are serum pH and serum potassium related?

A

Acidaemia increases serum potassium (potassium shifts extracellularly)
Alkalaemia decreases serum potassium (potassium shifts intracellularly)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the most common electrolyte disorder which causes cardiac arrest?

A

Hyperkalaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Causes of hyperkalaemia

A

Renal failure
Drugs e.g. ACEi, ARB, potassium-sparing diuretics
Tissue breakdown e.g rhabdo
Metabolic acidosis e.g. DKA
Endocrine disorders e.g. Addison’s
Diet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Signs/symptoms of hyperkalaemia

A

Flaccid paralysis
Paraesthesia
Depressed deep tendon reflexes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ECG abnormalities in hyperkalaemia

A

Prolonged PR
Flat/absent P waves
Peaked T waves
ST depression
S and T wave merging
Wide QRS
VT
Brady

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Management of hyperkalaemia in patients not in cardiac arrest

A

A-E assessment
12-lead ECG

Mild (5.5-5.9) - avoid further elevation (drugs etc.), calcium resonium/sodium zirconium (binds potassium). Onset of binders >4 hours.

Moderate (6.0-6.4) - insulin/dextrose (10 units insulin and 25g glucose over 15-30 minutes), futher IV glucose if pre-treatment BM less than 7, potassium binders

Severe (over 6.4) -
Without ECG changes - insulin/dextrose, give salbutamol (10-20mg), potassium binders. Consider cardiac monitoring.
With ECG changes - give calcium salts (calcium gluconate), insulin/dextrose, salbutamol, potassium binders, continuous cardiac monitoring.

Consider dialysis if refractory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How to manage hyperkalaemia in cardiac arrest

A

Give calcium chloride 10% 10ml, insulin/dextrose, sodium bicarbonate 50ml 8.4% by rapid injection if severe acidosis or renal failure
Consider dialysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Definition of hypokalaemia

A

Serum potassium below 3.5, severe below 2.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Causes of hypokalaemia

A

GI loss
Diuretics - loop/thiazide
Treated DKA
Endocrine disorders e.g. Cushing’s
Renal losses e.g. DI, dialysis
Magnesium depletion
Poor dietary intake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ECG features hypokalaemia

A

U waves
T wave flattening
ST segment changes
Arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How is hypokalaemia managed?

A

Potassium infusion. Maximum recommended dose is 20mmol/hour but more rapid infusion given if arrhythmia with risk of imminent cardiac arrest.
Continuous cardiac monitoring required.
Often need magnesium replacement.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Rate of cardiac arrest in dialysis patients

A

High risk for cardiac arrest, occurs up to 20x more frequently than general population. Survival to discharge comparable.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Management of cardiac arrest in dialysis patients

A

Dialysis nurse should operate haemodialysis machine
Stop dialysis, replace blood volume with fluid bolus
Disconnect from dialysis machine
Use dialysis access for drug administration
May require early dialysis post-resuscitation
Manage hyperkalaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Sepsis definition and associated mortality

A

Life-threatening organ dysfunction caused by dysregulated host response to infection.
SOFA score 2 or more reflects overall mortality risk of 10%
Septic shock - requiring vasopressors to maintain MAP 65 or more or lactate over 2 despite adequate fluid resuscitation
Septic shock has 40% mortality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How should sepsis be managed in cardiac arrest?

A

Fluid resuscitation
Broad spectrum antibiotics
Serum lactate
Measure urine output
Take blood cultures
Give high-flow oxygen target sats 94-98%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Modifications to resuscitation in poisoning

A

Wear PPE
Avoid mouth-to-mouth in chemicals such as cyanide, hydrogen sulphide, corrosives and organophosphates
Treat tachyarrhythmias with cardioversion
Correct glucose, electrolytes and acid-base disorders
Once resus started try to identify toxin - history from family/paramedics, clinical examination for toxidrome
Monitor temperature
May need prolonged resus as toxin metabolised/excreted - consider extracorporeal life support
Consult toxbase for specific treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Use of activated charcoal in toxin ingestion

A

Can consider single dose in ingestion of toxin known to be adsorbed by activated charcoal
Ensure intact or protected airway
Can give multiple doses if carbemazepine, dapsone, phenobarbital, quinine or theophylline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Management of opioid overdose

A

Naloxone if respiratory compromise
Naloxine - 400mcg IV, 800mcg IM, 800mcg SC or 2mg intranasally
Titrate dose to effect
May require ongoing infusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Management of benzodiazepine overdose

A

Flumazenil
Significant risk of withdrawals, seizures, arrhythmia, hypotension if used in benzo dependent patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Management of tricyclic antidepressant overdose

A

Can cause VT
Sodium bicarbonate if broad QRS
pH target 7.45-7.55

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Management of cardiac arrest due to local anaesthetic toxicity

A

Consider IV 20% lipid emulsion infusion. Initially 1.5ml/kg then 15ml/kg/hour up to maximum 12ml/kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Management of stimulant overdose

A

Small doses IV benzos
Nitrates for myocardial ischaemia secondary to cocaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Management of drug induced severe bradycardia

A

Atropine for organophosphate, carbamate or nerve agent poisoning - may require big doses
Isoprenaline for beta-blockers
May require transcutaneous pacing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Most common causes of death due to asthma

A

Severe bronchospasm leading to asphyxia
Cardiac arrhythmias caused by hypoxia
Dynamic hyperinflation in mechanically ventilated patients which reduces venous return and blood pressure
Tension pneumothorax

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Categorisation of asthma severity
Acute severe - any of RR >25 PEF 33-50% best or predicted HR >110 Inability to complete sentences in one breath Life-threatening - any of (in acute severe) Clinical signs - altered consciousness, exhaustion, arrhythmia, hypotension, cyanosis, silent chest, poor respiratory effort PEF less than 33% best/predicted Pa02 less than 8 Normal paCO2 (4.6-6) SpO2 less than 92% Near-fatal Raised pCO2 and/or mechanical ventilation with raised ventilation pressures
26
Management of acute asthma
Oxygen - target 94-98% Salbutamol/ipratropium Steroids IV magnesium sulphate 2g if not responding to bronchodilators Consider IV salbutamol, aminophylline Intensive care assessment Consider tracheal intubation if deteriorating despite drug therapy
27
Considerations for cardiac arrest due to asthma
Intubate early Use 10 breaths/minute If dynamic hyperinflation suspected can try chest wall compression or apnoeic period to relieve gas-trapping Hyperinflation increases transthoracic impedance but should be compensated for by defib - as usual consider increasing defib energy if not initially successful Look for reversible causes - always consider tension pneumothorax in asthma
28
Anaphylaxis prognosis
2% progress to cardiac arrest, 1% fatality
29
Criteria for diagnosis of anaphylaxis
Sudden onset and rapid progression of symptoms Airway/breathing and/or circulation compromise Skin and/or mucosal changes - absent in 20% Exposure to allergen supports diagnosis
30
Management of anaphylaxis
Do not walk/stand Remove trigger if possible e.g. stop infusions Monitor with pulse ox, BP, 3-lead ECG High flow oxygen, target sats 94-98% Give adrenaline - 0.5ml 1:1000 adrenaline IM Repeat doses at 5 minute intervals dependent on patients response Site for injection is anterolateral aspect of the middle third of the thigh Can use nebulised adrenaline as an adjunct to treat upper airway obstruction If refractory may need adrenaline infusion Give IVF challenge (crystalloid) Consider early tracheal intubation
31
Are antihistamines and steroids recommended for anaphylaxis?
Not routinely recommended Antihistamines can be given for cutaneous symptoms once patient stabilised Can consider given steroids after initial resus for refractory anaphylaxis
32
How should cardiac arrest due to anaphylaxis be managed?
Standard ALS Give 1mg adrenaline IV
33
When should mast cell tryptase be tested in anaphylaxis?
Minimum - one sample within 2 hours of start of symptoms Ideally - one sample at onset of symptoms, second sample at 1-2 hours, third sample at 24 hours
34
Starting concentration for adrenaline infusion in refractory anaphylaxis
0.5-1ml/kg/hour in adults and children
35
Definition and incidence of maternal cardiac arrest
At any stage in pregnancy to 6 weeks post-partum 1 in 36,000 pregnancies
36
Considerations for cardiac arrest in pregnancy
Place in left lateral position or manually displace uterus to the left if not possible - prevents compression of IVC Usual ALS principles Get obstetric, anaesthetic and neonatal help IV/IO access above diaphragm after 20 weeks (IVC compression) Prepare for emergency CS Increased risk of aspiration of gastric contents - early tracheal inbutation Usual defibrillation energy
37
Causes of cardiac arrest in pregnancy
Haemorrhage Drugs (e.g. magnesium for pre-eclampsia - give calcium) Cardiovascular disease - MI, dissection, aneurysm Pre-eclampsia and eclampsia Amniotic fluid embolism PE
38
When should peri-mortem caesarean section be considered and why?
Relieves IVC compression and may improve resuscitation of mother Allows for resuscitation of neonate Allows access for aortic clamping, internal cardiac massage Gestation less than 20 weeks - don't do, unlikely to compromise cardiac output and fetus not viable Gestation 20-23 weeks - do to allow for resuscitation of mother, survival of infant unlikely Gestation over 24 weeks - do to allow resuscitation of mother and infant
39
Commotio cordis definition
Actual or near cardiac arrest due to blunt impact to chest wall. Can cause VF/VT.
40
Principles of damage control resuscitation
Permissive hypotension - caution in TBI as may have raised intracranial pressure requiring higher cerebral perfusion pressure TXA ideally within 1 hour, no later than 4 hours Out-of-hospital - only essential interventions, rapid transfer to hospital. Don't delay for spinal immobilisation.
41
Treatment of traumatic cardiac arrest
Chest compressions - may not be effective if other causes e.g. tamponade/tension pneumothorax, need to consider and treat these early Focused USS to diagnose Prolonged CPR unlikely to be successful - stop if >20 minutes, excluded reversible causes, no cardiac activity on USS
42
Management of hypovolaemia and haemorrhage control during resuscitation
External compressible haemorrhage - elevation and direct pressure +/- dressing, tourniquet, topical haemostatic agents Non-compressible haemorrhage - splints including pelvic binder, manage with blood products, IVF, TXA until surgical/radiological control Immediate aortic occlusion in uncontrollable infradiaphragmatic torso haemorrhage - resuscitative thoracotomy and cross-clamping of descending aorta Neurogenic shock can exacerbate - fluid replacement and vasopressors if required IO access if IV not feasible
43
Signs of neurogenic shock
Warm, vasodilated peripheries Loss of reflexes below injured segment Severe hypotension and bradycardia
44
How is cardiac tamponade managed in traumatic cardiac arrest?
Resuscitative thoracotomy with clamshell incision and opening of pericardium Not reliable to do needle pericardiocentesis with or without US guidance as blood likely to be clotted
45
Causes of tension pneumothorax
Trauma Asthma or other pulmonary disease Clinical procedures e.g. CVC insertion
46
Management of tension pneumothorax
Needle decompression - long, non-kinking needle in 4th/5th intercostal space, mid-axillary line. Open thoracostomy as soon as appropriately trained clinicians present. Open thoracostomy - incision in 5th intercostal space, mid-axillary line and dissection into pleural space Chest drain should be sited following ROSC
47
Incidence of peri-operative cardiac arrest. Most common rhythms in perioperative arrest and rhythm with best chance of survival.
5 in 10,000 Asystole in 41% VF in 35% PEA in 14% Best chance of survival - PEA
48
How is perioperative cardiac arrest prevented/managed in high risk patients?
Invasive arterial blood pressure monitoring Attach defib pads pre-operatively Use warmed fluids/air to prevent hypothermia Ensure adequate IV access Adjust table to allow optimal chest compressions - can be done in prone position Use waveform capnography to monitor airway Give adrenaline in 50-100mcg increments rather than 1mg bolus for ALS reasons, give 50mcg boluses for anaphylaxis Stop operating unless you are treating a reversible cause of arrest
49
Causes of perioperative cardiac arrest
Hypovolaemia - bleeding Tension pneumothorax Loss of airway Anaphylaxis - most commonly due to neuromuscular blockers Vagal stimulation - causes bradycardia/asystole
50
How should perioperative cardiac arrest due to vagal stimulation be managed?
Stop surgical activity causing vagal stimulation Give atropine Start CPR
51
How is cardiac arrest following cardiac surgery managed?
External chest compressions - aim for SBP over 60, DBP over 25 at rate of 100-120 per minute If not achieving will need emergency retrosternotomy - indicates may have cardiac tamponade and/or hypovolaemia Consider other reversible causes - hypoxia, tension pneumothorax, pacing failure Treat witnesses VF/VT arrest with 3 successive shocks - if fails triggers need for emergency retrosternotomy Internal defibrillation if retrosternotomy performed with 20J Use adrenaline cautiously, IV doses up to 100mcg Atropine not recommended - pacing
52
Prevalence of death by drowning
350 accidental deaths in the UK from drowning each year M > F Commonest aged 20-30 Mostly in inland waters during summer
53
Cause of death by drowning
Submersion - initially breath hold reflex, swallows water. Hypoxia and hypercapnia develop. Reflex laryngospasm can prevent water entry to lungs. Eventually reflexes stop and aspirate water. Bradycardia due to hypoxia is what causes arrest. Immersion - hypothermia causes arrest (although may cause aspiration if splashes/unconscious)
54
Principles of water rescue of a drowning person
Try to rescue without entry to water If need to enter water better to have two people and take life jacket, flotation device or boat Efforts based on likelihood of survival - good chance if 5-10 minutes submersion, poor outcome if >25 minutes Review efforts at 30 and 60 minutes. May be appropriate up to 90 minutes in children and very cold water (hypothermic neuroprotective effect) Consider in water ventilation if delay reaching land Remove from water quickly - low risk spinal injury unless dive into shallow water Keep horizontal - hypovolaemia can cause collapse/arrest after removal from water
55
Initial resuscitation in drowning
Check for response Likely to have agonal breathing Give 5 ventilations with oxygen if possible Start chest compressions if no response - 30:2 Can bring up lots of foam - water mixed with surfactant and air Regurgitation of stomach contents and water common - turn on side and remove regurgitated material using suction if possiblw
56
Modifications to ALS for drowning
High flow oxygen Consider early intubation - reduced pulmonary compliance means SGA might not be effective PEEP values should be 5-10cm, may require 15-20 if severely hypoxaemic Insert NG to decompress stomach Palpation of pulse not reliable - use ECG, end-tidal CO2, consider echo ALS according to standard algorithm Treat hypothermia Likely to be hypovolaemic - give IVF
57
Should prophylactic antibiotic be given in drowning?
Pneumonia common but prophylactic antibiotics not recommended. May be used if grossly contaminated water e.g. sewage
58
Classification of hypothermia and clinical signs associated with each class
Body temp below 35 Mild 32-35 Moderate 28-32 Severe below 28 Stage I - mild hypothermia Conscious, shivering Core temp 32-35 Stage II - moderate hypothermia Impaired consciousness, not shivering Core temp 28-32 Stage III - severe hypothermia Unconscious, vital signs present Core temp 24-28 Stage IV - cardiac arrest or low flow state No or minimal vital signs Core temp less than 24 Stage V - death due to irreversible hypothermia Core temp less than 11.8
59
How can temperature be monitored in hypothermic patients?
Need low-reading thermometer Core temp in lower third of oesophagus is well correlated with heart temp - need an advanced airway Tympanic probe reliable but may be lower than core temp in cold environment Rectal/bladder temp measurement lag behind core temp - aren't recommended in severe hypothermia Need to use consistent measure throughout resus/rewarming
60
Why is diagnosis of death in hypothermia difficult?
Hypothermia has protective effect on brain and vital organs Can have good neurological recovery even after prolonged cardiac arrest if deep hypothermia before asphyxia Can cause very slow, low volume irregular pulse and unrecordable blood pressure No signs of life are not reliable for declaring death
61
Modifications to ALS for hypothermic patients
Check for signs of life for up to 1 minute If doubt start CPR Can make chest compressions difficult due to stiffness of chest wall - consider use of mechanical chest compression devices Early tracheal intubation Drug metabolism slow - withhold adrenaline until core temp over 30 Once core temp 30 double time between doses (e.g. adrenaline 6-10 minutes) As normothermia approached (over 35) return to normal standard drug protocols If VF detected - defibrillate as standard. If unsuccessful after 3 shocks don't give more until temp >30 Perform continuous CPR if able, can give delayed CPR (core temp under 28 can give CPR for 5 mins then stop for 5 mins, core temp under 20 can give CPR for 5 mins then stop for up to 10 mins)
62
Principles for rewarming hypothermic patients
Out-of-hospital Removal from cold environment Severe hypothermia - immobilise (risk of triggering VF) Remove wet clothes If mild - exercise to rewarm, insulation and passive rewarming Moderate - heat packs to abdomen Transfer quickly to hospital In-hospital Pre-arrest - forced warmed air, warmed IVF Deteriorating/arrest - non-extracorporeal rewarming (forced warm air, warmed IVF, peritoneal lavage) if not able to transfer to ECMO centre within 6 hours, ECMO if able
63
Mortality from heat stroke
10-33%
64
Features for diagnosis of heat stroke
Severe hyperthermia with body temperature over 40 Neurological symptoms including confusion, seizure, coma Exposure to high environmental temperatures or recent strenuous physical exertion Other symptoms - tachycardia, tachpnoea, hypotension, organ failure, dry/hot skin
65
Conditions other than heat stroke that present with high temperature
Drug toxicity Drug withdrawal Neuroleptic malignant syndrome Serotonin syndrome Sepsis Endocrine disorders - thyroid storm, phaeochromocytoma
66
Management of hyperthermia
Cooling to less than 39 degrees Methods including misting, fanning, cool IVF, cold water immersion Isotonic or hypertonic fluids (hypertonic to correct hyponatraemia) Manage seizures Correct electrolytes If cardiac arrest - continue cooling and follow ALS algorithm
67
Malignant hyperthermia definition
Genetic sensitivity of skeletal muscles to volatile anaesthetics and depolarising neuromuscular blocking drugs occuring during or after anaesthesia
68
Management of malignant hyperthermia
Stop triggering agents Give oxygen Correct acidosis and electrolyte abnormalities Start active cooling Give dantrolene If cardiac arrest - follow ALS algorithm, active cooling
69
ALS considerations in obese patients
Difficult chest compressions - from head, depth 6cm IV access difficult - IO access may be required Minimise bag-valve ventilation May be leak from SGA - need to continue 30:2 CPR Tracheal intubation early Escalate defib energy to maximum for repeated shocks