Chapter 14 Book Depression Flashcards

(46 cards)

1
Q

SE: Agitation, insomnia, headache, NV, Sexual Dysfunction, hyponatremia

Class

A

SSRI

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2
Q

This SNRI inhibits reuptake of norepinephrine more than 5 HT.

SE: OH, constipation, sweating, increased HR, palpitations, difficulty urinating, decreased appetite, Sexual Dysfunction

A

Levomilnacipran

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3
Q

This SNRI is approved for GAD.

SE: N, xerostomia, insomnia, somnolencia, constipation, reduce appetite, fatigue, sweating, blurred vision

A

Duloxetine

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4
Q

Venlafaxine SNRI is popular choice after SSRI.

WARNING

A

Monitor BP esp at high levels

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5
Q

Nefazodone, Trazodone, Vilazodone, Vortioxetine

This class

A

Serotonin Antagonist and Reuptake Inhibitor

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6
Q

Bupropion NDRI smoking stopper at low dose (poor man’s coccaine)

Has this Contradiction

A

Seizures

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7
Q

Use caution in older adults with Cardiac Problems, Elevated intraocular pressure, urinary retention, Hyperthyroidism, seizures, liver & Kidney dysfunction. Lethal in OD

A

Tricyclic antidepressants

Amitriptyline
Amoxapine
Doxepin
Imipramine
Nortriptyline

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8
Q

Disruptive mood dysregulation is….

Why was the diagnosis invented….

A

Constant & severe irritability and anger Ages 6 - 18

To prevent them from being labeled bipolar and taking wrong meds.

They grow outta it and become either depressed or Anxious

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9
Q

Persistent depressive disorder/ Formerly Dysrhthmias

Is this level ____ of depression that last 2 years Most days of the week

In addition have atleast 2 of the following: appetite problems, insomnia/ hypersomia, low energy, poor Self-Esteem, difficulty thinking hopelessness

A

Low level

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10
Q

Premenstrual Dysphoric Disorder

Can best be relieved by..

Which SSRIs

A

Regular exercise, carbohydrate rich foods & sleep, acupuncture, light therapy, relaxation.

Fluoxetine, Sertraline, Controlled release Paroxetine

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11
Q

Major depressive disorder is characterized by 5 or more symptoms of depression lasting atleast how long….

A

2 weeks

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12
Q

Can a person whose son just died last month be considered clinically depressed

A

Yes

Now the Bereavement exclusion is removed from the DSM

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13
Q

Leading cause of disability worldwide.

Most common psychological illness in USA

A

Depression

Anxiety

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14
Q

Women are more depressed than men.

Biracial people are the most depressed race

A

T & T

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15
Q

Two main neurotransmitters involved in mood are..

A

5 HT & norepinephrine

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16
Q

Serotonin or Norepinephrine

Attention
Behavior
Sleep
Appetite
Sex drive
Impulse control
Irritability

A

Norepinephrine

Attention
Behavior

Serotonin

Sleep
Appetite
Sex drive
Impulse control
Irritability

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17
Q

Hyperactivity of HPA & increased urine cortisol & elevated corticotrophin-releasing hormones
Are associated with depression?

A

T

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18
Q

C-reactive protein & interleukin-6 may play a role in depression. What do they both do?

A

Inflammation

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19
Q

This score on the PHQ-9 is qualification for a referral to mental help

20
Q

This is the Hallmark symptom of depression

A

Sleep pattern disturbance

21
Q

Words to describe Mood are….

A

Euthymic (normal)
Euphoric (Overly happy)
Angry
Irritable
Anxious
Apethic

22
Q

Moods can change quickly and need to be assessed often

T or F

A

F

Moods last from several hours to days.

Feelings & emotions change frequently

23
Q

Moods include

Worthless, guilt, helpless, hopeless, anger

T or F

A

F

These are feelings which can change in minutes. Moods are Euthymic, Euphoric, angry, irritable, anxious, apathetic

24
Q

Inability to solve problems may lead to this feeling / emotion

25
Are psychotic feature Hallucinations ever present with depression?
Yes, in severe
26
The core symptom of depression in children & adolescents is...
Same as adults Sadness & loss of pleasure
27
3 phases of treatment for major depression & time frame
Acute 6 - 12 weeks (reduction of depression & restoration of function) Continuation phase 4 - 9 months ( Prevent relapse ) Maintenance >1 year prevent further episodes. Meds may be Discontinued
28
Fluoxetine gives energy or makes tired Mirtazapine gives energy or makes tired Bupropion makes horny? Give these for chronic pain
Fluoxetine gives energy Mirtazapine makes tires Bupropion makes horny TCA or Duloxetine
29
Do SSRI have anticholinergic effects Dry mouth, blurry vision, urinary retention
No
30
Patient should Discontinue SSRI for how long before stating an MAIO
2 - 5 wks
31
How long to be off SSRI before starting MAIO
2 - 5 weeks
32
Esketamine affects this neurotransmitter
Glutamate
33
No eating / drinking 2 hrs before esketamine HTN = SE When can patient drive themselves home after treatment
Can't. Must be monitored for 2 hrs And no driving until following day
34
Brexanolone is .... Neurotransmitter.... Delivery method Serious SE
Postpartum GABA IV over 2.5 days Hypoxia, dry mouth, flushing, hot flashes
35
2nd line of treatment for depression
TCAS
36
TCAs Major SE
Anticholinergic: Urine retention Heart: Tachycardia Sedative: Use at night OD = Death
37
Recent MI Seizures Narrow angle glaucoma Preggers Contradictions for...
TCAs
38
SE of MAOI is HTN or hypotension
Both Hypotension common HTN with Tyramine
39
BP should be monitored with these meds
MAIO
40
HTN Crisis with MAIOs Gastric lavage / charcoal maybe done if recent ingested
True
41
Contradictions Cerebrovascular disease HTN CHF Liver disease Tyramine, L-tryptophan, dopamine Recurrent headaches Surgery in past 14 days <16
MAIO
42
SSRI can be used when preggers at the lowest effective dose. Except Which SSRI has Contradictions of heart defects in fetus
Paroxetine
43
Pre ECT Workup Chest x ray ECG urine analysis Cbc Blood urea Electrolyte And Discontinue this med
Benzo Stops the seizures
44
Type of amnesia associated with ECT
Retrograde Leading up to event and event itsefl
45
Low frequency transcranical magnetic stimulation may be used for seizures patients - Not High frequency. What is the only Contradictions to this procedure...
Metal implants, deep brain, cochlear implants.
46
Are symptoms of major depressive disorder enough to interfere with a person's social or job function
Yes