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1

Griffith performed experiments, which demonstrated

transformation in bacteria.

2

X-ray diffraction was used to determine that the diameter of a DNA molecule is ______

2 nm

3

Griffith's experiments were important because they showed

that the genetic material could be passed from one cell to another

4

In their experiments, Avery, MacLeod, and McCarty isolated a substance, which had a transforming activity. Which of the following destroyed that substance's ability to transform bacterial cells?

DNA digesting enzymes

5

The experiments with radioactively labeled phage that showed that DNA was the genetic material were performed by

Hershey and Chase

6

List components of a nucleotide:

phosphate group

nitrogenous base

sugar

7

Franklin used x-ray _____ to suggest that DNA has a helical structure.

diffraction

8

The DNA backbone is composed of

phosphate groups.

sugars.

9

Characteristics of the transforming substance isolated by Avery, MacLeod and McCarty.

RNA-digesting enzymes did not affect its transforming ability.

Protein-digesting enzymes did not affect its transforming ability.

DNA-digesting enzymes destroyed its transforming ability.

The elemental composition of the substance was very similar to that of DNA.

10

DNA's phosphodiester _____ is composed of sugars and phosphates.

backbone

11

The DNA structure proposed by Watson and Crick involves

a sugar phosphate backbone

a helical structure

two grooves (major and minor)

12

DNA replication that leads to the production of double helices with one parental strand and one newly synthesized strand is consistent with

semiconservative replication

13

Of the following list, which 3 items are required for DNA replication

nucleotides

template

polymerase

14

During DNA replication _______ strand is synthesized continuously while the ________ strand is synthesized as small fragments that are connected to each other to form a continuous strand.

Leading

Lagging

15

Features of the Watson and Crick model include:

a helical structure

a sugar phosphate backbone

a double stranded structure

16

DNA replication in eukaryotic cells is complicated by the fact that eukaryotic cells have

linear chromosomes

17

When the double stranded DNA helix is unwound, two single strands of DNA are formed. These strands have to be stabilized because their hydrophobic bases are exposed to water. The proteins that stabilize the two single strands are called

single-strand binding proteins

18

Which types of cells have more than one origin of replication?

Eukaryotes

19

The enzyme that relieves DNA supercoiling ahead of the replication fork is

DNA gyrase

20

The function of telomeres is to

protect the end of chromosomes