Chapter 18 + 19 Flashcards
(22 cards)
Why are the CH2COO- groups not same
Because prochirality one selected for over other
Names of citric acid cycle
Krebs
Tricarboxylic acid
What are the 5 cofactors in PDHC
Prosthetic: TPP lipoic acid FAD
cosubstrates: NAD+ coenzyme A
What is acetyl coA synthesized from and with what
Pyruvate with pyruvate dehydrogenase
What are the 3 steps regulated in CAC
1 3 4 the irreversible
Citrate synthetase
isocitrate dehydrogenase
Alpha ketoglutarate dehydrogenase
Alpha ketoglutarate dehydrogenase regulation
Stimulated AMP
inhibited NADH succinyl coA
Energy high maintenance by Precursor glutamine formed for anabolic amino acid synthesis
How is citrate synthase regulated
Controlled by oxaloacetate
More then stimulated
Inhibited by product
Isocitrate dehydrogenase regulation
Stimulated NAD+ ADP
inhibited NADH ATP
What are the steps to convert pyruvate to acetyl coA
Decarboxylation
Oxidation
Transfer coA
What is pyruvate dehydrogenase complex similar to
Alpha ketoglutarate dehydrogenase
Which catalyze reaction that generate CO2
Isocitrate dehydrogenase
Pyruvate dehydrogenase
Alpha ketoglutarate dehydrogenase
Pyruvate dehydrogenase complex
Converts pyruvate to acetyl coA
Citrate synthase
Condenses oxaloacetate and acetyl coA
Aconitase
Catalyzes formation of isocitrate
Isocitrate dehydrogenase
Catalysis formation of alpha ketoglutarate
Alpha ketoglutarate dehydrogenase
Synthesizes succinyl coA
Succinyl coA synthetase
Generates ATP
Succinatr dehydrogenase
Synthesizes fumarate
Fumarase
Generates malate
Malate dehydrogenase
Catalyzes formation of oxaloacetate
Pyruvate carboxylase
Converts pyruvate to oxaloacetate
Where does energy come from to drive formation of citrate
Hydrolysis of thioester
