Chapter 18

Question 1

The use of drugs to treat a disease

Answer 1

Chemotherapy

Question 2

Interfere with the growth of microbes within a host

Answer 2

Antimircobial Drugs

Question 3

A substance produced by a microbe that, in small amounts, inhibits another mircobe

Answer 3

Antibiotic

Question 4

A drug that kills harmful microbes without damaging the host

Answer 4

Selective Toxicity

Question 5

___________ originated the concept of selective toxicity

Answer 5

Paul Ehrlich

Question 6

What are the two antimicrobial types?

Answer 6

Synthetic and Antibiotics

Question 7

______ toxicity means that a drug should harm the pathogen but not the host

Answer 7

Selective

Question 8

This dose of selective toxicity does hard to the host

Answer 8

Toxic Dose

Question 9

This dose in selective toxicity eliminated the pathogen in the host

Answer 9

Therapeutic dose

Question 10

What does the chemotherapeutic index equal?

Answer 10

Toxic Dose / Therapeutic dose

Question 11

Domagk found _____ which was a red dye found to inhibit some gram-positive bacterial species

Answer 11

Prontosil

Question 12

Drugs have a range of pathogens on which they will work on, this is called _____ _______

Answer 12

Antimicrobial Spectrum

Question 13

____-Spectrum drugs affect many taxonomic groups

Answer 13

Broad

Question 14

____-Spectrum drugs affect only a few pathogens

Answer 14

Narrow

Question 15

These are drugs made for enzyme binding sites, the folic acid is needed for DNA synthesis, they treat infections

Answer 15

Synthetic Drugs

Question 16

This unwinds the DNA in replication before DNA helicase does

Answer 16

Ciprofloxacin

Question 17

____ inhibits cell wall biosynthesis of Mycobacterium

Answer 17

Isoniazid

Question 18

_____ inhibits peptidoglycan biosynthesis

Answer 18

Ampicillian

Question 19

This antibiotic is popular, but has a resistance disadvantage

Answer 19

Penicillin

Question 20

Antibiotics are most effective during the ___ phase of growth

Answer 20

log

Question 21

_____ are also able to penetrate the CNS, making them useful against meningitis caused by pneumococci, meningococci, H. influenzae, and susceptible E. coli, Klebsiella, and penicillin-resistant N. gonorrhoeae.

Answer 21

Non-Penecillian Beta Lactam

Question 22

______ is indicated for the treatment of serious, life-threatening infections by Gram-positive bacteria which are unresponsive to other less toxic antibiotics

Answer 22

Vancomycin

Question 23

_________ antibiotics effect the cell membrane, toxic internally and can be used for a topical use on humans like polysproin

Answer 23

Polypeptide

Question 24

Bacitracin works on a ___ _____

Answer 24

cell wall

Question 25

Neomycin is protein synthesis inhibitor and blocks _______

Answer 25

Transcription

Question 26

Prokaryotes have 70d ribosomes, which means they are ______ than eukaryotes and can be single handedly killed without effecting the ribosomes of the Eukaryotes

Answer 26

smaller