Chapter 2 - Drugs And The Body Flashcards Preview

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Flashcards in Chapter 2 - Drugs And The Body Deck (18):
1

Analogy for receptor sites

Lock and key
Nearby enzymes break down reacting chemicals and open receptor sites for further stimulation

2

Agaonists

Act directly with receptor sites, with natural chemicals that would normally occur at that site
Ex. insulin moves glucose into the cell

3

Noncompetitive Antagonist

Reach with specific receptor sites on a cell, and prevent reactions with another chemical with s different receptor site on that cell.

4

What system do enzymes work

Cascade.
Activates one chemical then that chemical reacts with another.

5

What are the cells that reproduce rapidly and need and increased drug dosage

Bone marrow, gi, hair follicles

6

Pharmacodynamics vs pharmacokinetics

Pharmacodynamics- how the drug acts on the body
Pharmacokinetics- how the body work on the drug

7

List four phases of drug digestion

Absorption
Distribution
Biotransformarion
Excretion

8

Absorption

The time it takes from the drug is introduced to reach the circulating fluids

9

Binders do what?

Used to bark down in certain acidity and break down in certain acidities
Step such acidification is higher and drug is exposed to acid more longer

10

How ar drugs given IM absorbed

Must reach the capillaries in the muscle and then sent in circulation.
Men reach peak levels faster than women

11

Passive diffusion

Occurs against a concentration gradient
Doesn't require an energy

12

Name the 4 ways drugs act

Replace/substitute missing chemicals
Increases and stimulate certain cells
Depress cellular activity
Interfere functioning of foreign cells

13

Active diffusion

Does require energy to transport a molecule against a membrane

14

No lipid solvable drugs can't be transferred through the what

Blood brain barrier

15

First pass effect

Where most of the drug is destroyed and never reaches a therapeutic level

16

Phase 1 of biotransformation

Oxidation, reduction, hydrolysis of the drug

17

Phase 2 of biotransformation

Conjunction reaction that makes the drug more polar SUVs readily excreted in the kidneys

18

Half life definition

Time it takes for a drug to decrease to one half of the peak level