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Immunology-Serology > Chapter 3 - Components of Adaptive Immunity > Flashcards

Chapter 3 - Components of Adaptive Immunity Flashcards

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1
Q

Differentiate active and passive immunity.

A

Active immunity - antigen is introduced to the individual

Passive immunity - antibody is introduced to the individual

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2
Q

Immunity acquired from actual infection is an example of:

A

Natural, active immunity

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3
Q

Immunity acquired from placental transfer and colostrum is an example of:

A

Natural, passive

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4
Q

Colostrum contains which type of antibodies?

A

IgA

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5
Q

Immunity acquired from injection of immunoglobulins is an example of?

A

Artificial, passive

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6
Q

Immunity acquired from vaccines is an example of?

A

Artificial, active

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7
Q

What are the different types of lymphocytes?

A

B, T, NK

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8
Q

Which WBC/s are considered as an agranulocyte?

A

Lymphocytes only. Monocytes are granulocytes.

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9
Q

A DNA polymerase active during the process of Ig and T cell receptor gene rearrangement early in a precursor B or T cell’s life.

A

Terminal deoxynucleotidyl transferase (TdT)

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10
Q

Antigenic features of leukocytes that are differentiated by groups of monoclonal antibodies expressing common activity.

A

Cluster of differentiation

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11
Q

Which lymphocyte is associated with humoral immunity?

A. T cells
B. B cells

A

B. B cells

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12
Q

Which lymphocyte is associated with cellular immunity?

A. T cells
B. B cells

A

A. T cells

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13
Q

What are the markers for T cells?

A

CD 2, CD 3, CD 4, CD 8

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14
Q

What are the markers for B Cells?

A

sIg, CD 19, CD 21,

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15
Q

If B cells produce antibodies, what does T cells produce?

A

Lymphokines

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16
Q

Which is more abundant in circulation, T cells or B cells?

A

T cells

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17
Q

Which has a shorter life span, T cells or B cells?

A

B cells (3-5 days)

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18
Q

What is the lifespan (range) of T cells?

A

4-10 years

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19
Q

responsible for the maturation, differentiation and growth of lymphocytes.

A. Primary lymphoid organs
B. Secondary lymphoid organs

A

A. Primary lymphoid organs

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20
Q

Also known as the central lymphoid organs

A. Primary lymphoid organs
B. Secondary lymphoid organs

A

A. Primary lymphoid organs

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21
Q

What are the primary lymphoid organs?

A

BM and thymus

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22
Q

Main site (organ) of antibody production.

A

Spleen

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23
Q

Which secondary lymphoid organ detects antigen found in tissue fluids?

A

Lymph nodes

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24
Q

Which secondary lymphoid organs detect antigens in the blood?

A

Spleen

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25
Largest secondary lymphoid organs.
Spleen
26
What does the secondary lymphoid organ BALT acronym stand for?
Bronchus-associated lymphoid tissue
27
The trapping site of antigens. A. Primary lymphoid organs B. Secondary lymphoid organs
B. Secondary lymphoid organs
28
This is where the production of antibodies and lymphokines and phagocytosis occurs. A. Primary lymphoid organs B. Secondary lymphoid organs
B. Secondary lymphoid organs
29
This is where antigenic lymphopoiesis occurs. A. Primary lymphoid organs B. Secondary lymphoid organs
B. Secondary lymphoid organs
30
Where can you find T cells?
Medullary, perifollicular and paracortical region of lymph nodes / periarteriolar regions of spleen / thoracic duct of the circulatory system
31
Where can you find B cells?
Follicular and medullary (germinal centers) of lymph nodes / primary follicles and red pulp of spleen / follicular region of GALT
32
Latency is associated with which virus?
Herpes virus
33
What do you call a chickenpox reinfection?
Shingles
34
The traditional marker for T cells
CD2
35
The traditional marker for B cells
Surface immunoglobulins (sIg)
36
The new marker for T cells
CD3, CD4 and CD8
37
The new marker for B cells
CD19, CD20, CD21
38
Most commonly used technique to differentiate B from T cells.
Sheep RBC (E-rosetting)
39
With which lymphocyte will sheep’s RBC form rosette?
T cells
40
Growth of haemophilus uses which animal blood?
Horse blood
41
NK cell was previously classified as?
T cell
42
How was NK cell different from T cells?
NK cell is CD3 negative unlike T cells
43
What are the markers for NK cell?
CD2, CD16, CD56 (CD3 negative)
44
Where would you most likely find virgin or naive lymphocytes? A. Primary lymphoid organs B. Secondary lymphoid organs
A. Primary lymphoid organs
45
Which lymphocyte is responsible for immune response and are involved in antibody regulation?
T cells
46
Which lymphocyte is the precursor cell in antibody production?
B cells
47
Subsets and subpopulation of T cells
Subsets: T helper cells, T cytotoxic cells Subpopulation: T regulatory cells
48
Which B cell is the most common B cell in circulation?
B2
49
Which B cell is CD5 positive?
B1
50
In which stage of T cell in its development will it start containing both CD4 & CD8?
Double positive thymocytes
51
Which interleukin activates T cells?
IL-2
52
In what stage of T cell development does positive and negative selection occur?
Double positive thymocytes
53
Positive selection of T cells means: A. Proliferation of that T cell would be allowed B. Proliferation of that T cell would not be allowed
A. Proliferation of that T cell would be allowed
54
Which stage of T cell in its development would it be capable of producing lymphokines?
Sensitized T cell
55
At which stage of T cell development can we start distinguishing between helper and cytotoxic T cells?
Mature T cells
56
At which B cell stage of development does it start to rearrange the genes coding for the heavy chain?
Pro-B cell
57
Pro-B cells are CD___ and CD___ positive.
CD19, CD45
58
At which B cell stage will heavy chains and sometimes surrogate light chains start to appear?
Pre-B cell
59
The first Ig isotype that appears on the surface of B cells.
IgM
60
Which cell produces antibodies?
Plasma cells
61
Which mature B cell remains at circulation? A. Follicular B. Marginal
B. Marginal
62
CD21 starts to appear at which B cell stage?
Immature B cell
63
Sheep RBC receptor in T cells.
CD2
64
T cell receptor that is a part of T cell antigen-receptor complex
CD3
65
Receptor of MHC class II molecule
CD4
66
Receptor of MHC class I molecule
CD8
67
A substance that can cause mitosis.
Mitogen
68
Enumerate 3 T cell mitogens
Pokeweed antigen (PWA), phytohemagglutinin (PHA), concanavalene A (CON-A)
69
Enumerate 2 B cell mitogens
Pokeweed antigen, LPS
70
Gold standard to ID blood cells
Flow cytometry
71
Technique used to separate lymphocytes from other blood cells
Ficoll-Hypaque
72
Commonly used specific gravity in performing Ficoll-Hypaque.
1.077
73
The medium used to cultivate lymphocytes
Roswell Park Memorial Institute (RPMI)
74
Which type of T helper cells mediate cell immunity?
Type 1 T helper cells
75
Which type of T helper cells mediate antibody production?
Type 2 T helper cells
76
Which type of T helper cells suppress antibody production?
Type 3 T helper cells
77
sIg found on this cell’s cytoplasm. A. B cell B. Plasma cell C. T cells
B. Plasma cells
78
sIg found on this cell’s surface A. B cells B. Plasma cells C. T cells
A. B cells
79
HIV receptor
CD4
80
IL-2 receptor
CD25
81
EBV receptor
CD21

Immunology-Serology (6 decks)

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