Chapter 3 - Signal Transduction (2019) - Evals #3 by Keim

Question 1

True or False:

Transducin is a typical trimeric g protein.

Answer 1

True

Question 2

Jakstat pathway

Answer 2

4 2 3 5 6 1

Question 3

Beta subunit that anchors to the g protein.

Answer 3

None of the choices

Question 4

cGMP dependent protein kinase.

Answer 4

PKG

Question 5

PKA has:

Answer 5

2 regulatory

2 catalytic subunits

Question 6

Indirect pathway in AA except:

Answer 6

PLA2

Question 7

Which of the following is not true about serine/threonine kinases?

Answer 7

Sequence of GPCR binding

Question 8

What anchors beta subunit of G proteins?

Answer 8

None of the choices

Ratio:
Alpha - myristyl or palmitoyl
Gamma - prenyl

Question 9

What is calcineurin?

Answer 9

PP2B

Question 10

Src and JAK bind to tyrosine kinase-associated receptor

converts gtp to gcmp:

Answer 10

Guanyl cyclase

Question 11

Picture:

Which of the following is a second messenger?

Answer 11

cAMP

Question 12

DAG is a:

Answer 12

Protein kinase C

Question 13

When epinephrine binds to the receptor-membrane activating the cAMP, which of the following does not happen?

Answer 13

G-protein is freed from the tether and

diffused away from the cell membrane

Question 14

Contains DNA Binding domain, involved in dimerization.

Answer 14

Domain

Question 15

Which is true in the PIP3K pathway?

Answer 15

It has p85 and p110 subunit.

Question 16

Which of the following catalytic receptors chuchu atrial natriuretic peptide …. increase? cGMP and decreases BP?

Answer 16

Receptor guanylyl cyclase

Question 17

Which of the following is false about receptor Tyrosine kinase?

Answer 17

It is highly cytosolic

Question 18

Which is false about MAPK?

Answer 18

It has 3 intermediary kinases before MAPK.

Question 19

Which of the following is mediated by “heat shock” or chaperone mediated proteins?

Answer 19

MR

Question 20

All of the ff are heterodimeric except:

Answer 20

Mineralocorticoid

Question 21

SH2 domain:

Answer 21

Binds phosphorylated tyrosine

Question 22

Type of receptor na may PHOSPHORYLATION na word kay long question:

Answer 22

Receptor tyrosine kinases

Question 23

What nucleo-receptor domain contains the DNA-binding domain and is involved in dimerization?

Answer 23

C region

Question 24

DAG is directly activated by what protein kinase?

Answer 24

PK C

Question 25

Which activates cytosolic soluble guanylyl cyclase?

Answer 25

NO (Nitric oxide)

Question 26

In blood volume expansion, this receptor mediates the dilation of blood vessels, relaxation of muscles and enhance excretion into the urine?

Answer 26

Receptor guanylyl cyclase

Question 27

There are 5 classes of catalytic receptors, which of the ff catalyze generation of cGMP from GTP?

Answer 27

Receptor Guanylyl cyclases

Question 28

True of indirect pathway except? A. Ligand coupled to PLC B. Agonist that raises Ca C. PLA2 D. Pathways that activates MAPK

Answer 28

C. PLA2 (Direct pathway)

Question 29

A chemical messenger hormone was secreted and combined with each receptor on other cell types very nearby, the hormone also combined receptors of the cell from which it was release the hormone was in such low concentration that did not any affect cell that there nearby ,we would best classifies the hormone as?

Answer 29

B and C (Autocrine and Paracrine

Question 30

When epinephrine or glucagon bind to their receptor on the membrane an activate the CMP cascade, which of the following does NOT happen?

Answer 30

G protein is free from the tether and infuses away from the cell membrane.

Question 31

PK for cGMP?

Answer 31

G