Chapter 31 - Memory Flashcards Preview

X NEVR2030 Komprimert Introduksjon til Nevrovitenskap > Chapter 31 - Memory > Flashcards

Flashcards in Chapter 31 - Memory Deck (57):

Humans have at least two qualitatively different systems of information storage. These are generally referred to as ..

1. declarative memory
2. nondeclarative memory


Humans have at least two qualitatively different systems of information storage. These are generally referred to as declarative memory and nondeclarative memory. What is declarative memory?

Declarative memory is the storage and retrieval of material that is available to consciousness and can in principle be expressed by language (i.e. "declared").


Humans have at least two qualitatively different systems of information storage. These are generally referred to as declarative memory and non declarative memory. What is nondeclarative memory?

Nondeclarative memory (also referred to as procedural memory) is not available to consciousness, at least not in any detail. Such memories involve skills and associations that are, but large, acquired and retrieved at an unconscious level.


The ability to remember a phone number is an example of .... memory



Knowing how to use your phone to dial a number is an example of ...... memory



In addition to the types of memory defined by the nature of what is remembered, memory can also be categorised ...

Memory can also be categorised according to the time over which it is effective.


Three temporal classes of memory are generally accepted. Which?

1. Immediate memory
2. Working memory
3. Long-term memory


What is meant by immediate memory, a temporal class of memory?

Immediate memory is the routine ability to hold ongoing experiences in mind for fractions of a second.


How is the capacity of immediate memory?

The capacity of immediate memory is very large, and each sensory modality appears to have its own semi-independent "memory register".


What is meant by working memory, a temporal class of memory?

Working memory is the ability to hold and manipulate information in mind for seconds to minutes while it is used to achieve a particular goal.


What is meant by long-term memory, a temporal class of memory?

Long-term memory entails retaining information in a more permanent form of storage for days, weeks, or even a lifetime.


What is an engram?

Engram is the physical embodiment of any memory in the neuronal machinery. (I think it's a cognitive psychology term)


The way in which immediate and short-term memories are gradually encoded as long-term memories is called..

memory consolidation.


Mention two experiments on priming that is relevant for memory consolidation.

1. In a commonly used test, the subject is presented at time 1 with a list of words to study and is later tested using a word-stem completion task. The stems could also be completed from list B, which comprises words the subject did not see during the initial session. Subjects typically complete the stems with about 25% more studied that unstudied words; this percentage represents the effect of priming.
2. The information stored in priming is not particularly reliable. A list of nouns of sweet objects is read aloud to a subject, and they are later asked to write down as many as they can remember from this list. Typically, about half the students report that the word "sweet" was included in the list, even though it was not.


Give examples on how meaning influences memory.

1. The person who holds the world record for remembering the most digits of pi (67, 000), did so by associating the digits with musical notes and singing the number strings.
2. A college student who was paid to remember randomly presented numbers increased his skill by associating the numbers with dates or times at track meets (he was a runner).


What is conditioned learning?

The generation of a novel response that is gradually elicited by repeatedly pairing a novel stimulus with a stimulus that normally elicits the response being studied.


Which forms of conditioned learning do we know of?

1. Classical conditioning
2. Operant conditioning


What is classical conditioning?

Classical conditioning occurs when an innate reflex is modified by associating its normal triggering stimulus with an unrelated stimulus; by virtue of the repeated association, the unrelated stimulus eventually triggers the original response.


Classical conditioning was famously demonstrated by whom?

The Russian psychologist Ivan Pavlov.


What is operant conditioning?

Operant conditioning refers to the altered probability of a behavioural response produced by associating the response with a reward.


What is the most famous study on operant conditoning?

Frederick Skinner's experiments at Harvard, where pigeons or rats learned to associate pressing a lever with receiving a food pellet.


If the conditioned animal performs the desired response but the reward is no longer provided, the conditioning gradually disappears, a phenomenon called...



The ability to forget unimportant information may be critical for normal life. Although forgetting is a normal and essential mental process, it can also be pathological, a condition called ..



Two different types of amnesia. Which?

1. Anterograde amnesia
2. Retrograde amnesia


What is anterograde amnesia?

Anterograde amnesia is an inability to establish new memories.


What is retrograde amnesia?

Retrograde amnesia is a difficulty retrieving memories.


Which structures are associated with declarative memory disorders?

1. Thalamus
2. Hippocampus
3. Fornix
4. Amygdala
5. Mammillary body


The hippocampus is located ...

In the medial temporal lobe.


There is an idea that long-term memory traces are distributed over the entire cortex. This was studied by Karl Lashley in the 1920s. What were his findings?

Lashley worked with rats and maze-learning whilst removing cortex. He summarised his findings in terms of what he called the mass action principle, which states that any degradation in learning and memory depends on the amount of cortex destroyed; and that the more complex the learning task, the more disruptive the lesion.


"fun" fact: how was electroconvulsive therapy invented?

This remarkably useful treatment was discovered because depression in epileptics often remitted after a spontaneous seizure.


What are common negative consequences of electroconvulsive therapy?

ECT often causes both anterograde and retrograde amnesia. Patients typically do not remember the treatment itself or the events of the preceding days, and their recall of events over the previous 1-3 years can be affected.


How does our knowledge of electroconvulsive therapy aid us in our quest for knowledge of the localisation of memory?

The nature of amnesia following ECT supports the conclusion that long-term declarative memories are widely stored in the cerebral cortex, since the sis the part of the brain predominantly affected by this therapy.


The retrieval of memories appears to involve which parts of the cortex?

The association cortexes, particularly the frontal cortex.


Patients such as H.M., N.A., and R.B. had no difficulties establishing or recalling nondeclarative memories, indicating that such information is laid down using a different anatomical substrate from that used in declarative memory formation. Nondeclarative memory apparently involves ...

.. the basal ganglia, prefrontal cortex, amygdala, sensory association cortexes, and cerebellum - but not the medial temporal lobe or midline diencephalon.


Simple sensory-motor conditioning such as learning to blink following a tone that predicts a puff of air directed at the eye is severely reduced if ..

If the patient has suffered damage to the cerebellum.


Learning new motor skills is incredibly difficult if you have suffered damage to ...

the basal ganglia and prefrontal cortex.


Memory and Aging. What is the most obvious way, post-mortem, you can see the brain deterioration from aging?

The average weight of the normal human brain steadily decreases from early adulthood onward.


What is dementia?

Dementia is a syndrome characterised by failure of recent memory and other intellectual functions. It is usually insidious(stealthy) in onset but tends to progress steadily.


What is the most common dementia?

Alzheimer's disease is the most common dementia, accounting for 60-80% of cases in the elderly.


Alzheimer's disease afflicts a percentage of the U.S. population. X%



How many percent of the population over 85 years suffer from alzheimer's disease?



What are the earliest signs of Alzheimer's disease?

Impairment of recent memory function and attention, followed by failure of language skills, visual-spatial orientation, abstract thinking and judgement.


A tentative diagnosis of Alzheimer's disease is based on characteristic clinical features, but can only be confirmed by the distinctive cellular pathology evident in the post mortem brain. What are these histopathological changes?

1. Collections of intraneuronal cytoskeletal filaments called neurofibrillary tangles.
2. Extracellular deposits of an abnormal proteins (called amyloid) in so-called senile plaques.
3. A diffuse loss of neurons.


The histopathological changes present in the Alzheimer brain are most prominent in which structures?

1. Neocortex
2. Limbic structures
3. Brainstem nuclei


Which structures are limbic structures?

1. Hippocampus
2. Amygdala
3. The cortices associated with those two.


What seems to cause the early-onset AD?

Mutations of the APP (amyloid precursor protein) gene on chromosome 21.


Why did researchers look at chromosome 21 for the cause of the early-onset AD?

Investigators long suspected that a mutant gene responsible for familial AD might reside on chromosome 21, primarily because clinical and neuropathology features similar to AD often occur in individuals with Down syndrome (which is caused by an extra copy of chromosome 21), but with a much earlier onset.


What is apolipoprotein E (ApoE)?

Apolipoprotein E is a protein that normally chaperones cholesterol through the bloodstream. Warren Strittmatter and Guy Salvesen discovered this protein when they took the CSF of Alzheimer's patients and mixed it with amyloid beta. Apolipoprotein E was found to bind to amyloid with great affinity.


What is a protein isoform?

A protein isoform is any of several different forms of the same protein. Different forms of a protein may be produced from very closely related gene duplicates.


Apolipoprotein E was found to bind to amyloid beta. Margaret Periack-Vance, Allen Roses and their colleagues had an interesting finding as well. What was it?

They found that affected members of some families with the late-onset form of Ad exhibited an association with genetic markers on chromosome 19. This finding was of particular interest because a gene encoding an isoform of ApoE is located in the same region of chromosome 19 implicated by the association studies.


ApoE has how many alleles?

It has three major alleles: e2, e3, and e4.


How do late-onset AD patients differ in their alleles for ApoE?

The frequency of allele e4 in the general population is 0.14, but in late-onset AD patients it's 0.52.


How many percent of individuals that have no alleles of e4 develop AD by age 75?



How many percent of individuals that have two copies of allele e4 develop Alzheimer by age 75?



Inheriting the e4 form of ApoE means you will get AD?

No. It increases the risk, and especially if you have both copies of it. But it's not definitive.


Short: What is the Fornix?

The fornix (Latin: arch) is a C-shaped bundle of nerve fibers in the brain that carries signals from the hippocampus to the mammillary bodies and then to the anterior nuclei of thalamus.


Short: What is the mammilary body?

The mammillary bodies are a pair of small round bodies, located on the undersurface of the brain that, as part of the diencephalon, form part of the limbic system. They are located at the ends of the anterior arches of the fornix. Neuroanatomists have often categorized the mammillary bodies as part of the hypothalamus.