Chapter 4 - Communication In The Nervous System Flashcards

1
Q

What are 3 types of interneurons?

A

Stellate (star-shaped) cell
• Small; many dendrites extend around the cell body; larger brains contain more (behavioral complexity).

Pyramidal cell
• Has a long axon, a pyramid-shaped cell body, and two sets of dendrites, apical and basal; carries information from cortex to rest of brain and spinal cord.

Purkinje cell
• Is distinctively shape with extremely branched dendrites that form a fan; carries information from cerebellum to rest of brain and spinal cord.

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2
Q

What are glial cells?

What are the 5 classes?

A

Provides insulation, nutrients and support

Aid in repairing neurons and eliminating waste products

Produced THROUGHOUT an organisms life

5 classes:

  1. Ependymal cell
  2. Astrocyte
  3. Microglial cell
  4. Oligodendroglial cell
  5. Schwann cell
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3
Q

What are ependymal cells?

(TYPES OF GLIAL CELLS)

A

Small, ovoid; found in the walls of the ventricles

Make and secrete cerebrospinal fluid (CSF)

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4
Q

What are astrocytes?

(TYPES OF GLIAL CELLS)

A

Star shaped, symmetrical

Provide structural support for neurons

Transport substances between neurons and capillaries (blood–brain barrier)

Enhance brain activity by providing fuel to active brain regions

Promote healing of damaged brain tissue

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5
Q

What are microglia?

(TYPES OF GLIAL CELLS)

A

Originate in the blood as offshoot of immune system

Involved in scavenging of debris (e.g., dead cells); phagocytosis

Monitor the health of brain tissue and play the role of its immune system

Identify and attack foreign tissue

Invade the area to provide growth factors that aid in repair when brain cells are damaged

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6
Q

What are the 2 types of MYELIN-producing glial cells?

A
  1. Oligodendroxcytes
    - produce myelin in the BRAIN & SPINAL CORD
    - 75% glial cells in brain
  2. Schwann cells
    - produce myelin in the REST of the nervous system
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7
Q

What is included in a cell membrane?

A

Phospholipid bilayer

Selectively permeable membrane

Phosphate head, lipid tail

Hydrophobic tail, hydrophilic head

Protein channels

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8
Q

Explain the difference b/w polarization, voltage and resting potential

A

Polarization: a state in which there is a difference in electrical charge between the INSIDE and OUTSIDE of the NEURON

Voltage: measure of the difference in electrical charge between TWO POINTS

Resting potential: difference in charge between INSIDE and OUTSIDE of MEMBRANE of a neuron at REST

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9
Q

What is a voltmeter?

A

Device that measures the difference in electrical potential b/w two bodies

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10
Q

Explain ions in terms of (+) & (-) and where they lie on the cell membrane?

A

(+) = Na+, K+

(-) = Cl-, A- (organic anion)

A- and K+ Ions have HIGHER CONC INSIDE the axon

Cl- ions and Na+ are MORE CONC OUTSIDE the axon

***We are gonna focus more on the +

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11
Q

What is force of diffusion?

A

Tendency of ions to move through membrane to LESS concentrated side

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12
Q

What is electrostatic pressure?

A

Force where ions are repelled from SIMILARLY charged, ATTRACTED to OPPOSITELY charged

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13
Q

What is concentration gradient?

A

Ink dropped into water diffuses

Until it is EQUALLY distributed through-out water

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14
Q

What is voltage gradient?

A

If salt solution is poured into water

Neg ions will flow down electrostatic gradient

UNTIL + and - is everywhere

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15
Q

What is the sodium potassium pump?

A

Large protein molecules that move Na+ ions through cell membrane to OUTSIDE, K+ ions back INSIDE

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16
Q

Ion channels can be “____________ gated or ____________ gated, or _____ gated ”

A

Chemically; electrically; not

CHEMICAL: neurotransmitters/hormones

ELECTRICAL: change in electrical potential of membrane

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17
Q

Explain the process of the sodium potassium pump

A
  1. K+ is free to ENTER & LEAVE the cell
  2. Na+ channels are ordinarily CLOSED to PREVENT entry to Na+
  3. Na+ - K+ pumps of THREE Na+ for EVERY TWO K+

***Basically FUCK Na+, who even likes them?

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18
Q

What are voltage-activated ion channels?

A

Gated protein channels that OPEN OR CLOSE only at SPECIFIC membrane voltages

CLOSED at membranes resting potential

Na+ channels are MORE SENSITIVE than K+ channels, these OPEN SOONER

***Na+ sensitive bc everyone HATES them

19
Q

What is depolarization?

What is local potential?

A

If local potential EXCEEDS the threshold for activating electrically gated channels, then an ACTION POTENTIAL occurs
- usually due to an influx of sodium ions

Local potential:
- partial depolarization
- graded potential (varies in magnitude depending on strength of stimulus)

20
Q

What is the action potential?

A

Abrupt DEPOLARIZATION of membrane that ALLOWS neuron to COMMUNICATE

Is UNGRADED = (all-or-none law: occurs at FULL strength or NOT AT ALL)

Is NONDECREMENTAL (travels down axon w/out any decrease in size, propagate at each successive point)

21
Q

Who was Camilo Gogi?

A

Staining tissue showed and “interconnected net of fibres”

Called it a NERVE NET

22
Q

Who was Ramon y Cajal?

A

Staining embryonic cells showed discrete cells of many sizes

Neurons are the nervous systems FUNCTIONAL UNITS

NEURON HYPOTHESIS

Todays accepted theory of brain organization

23
Q

Explain the 3 basic structures of a neuron?

A
  1. Cell body (soma):
    - core region of cell
    - contains organelles
    - INTEGRATES INFO
  2. Dendrites:
    - branching extensions
    - COLLECTS INFO
  3. Axon:
    - main projection from soma
    - CARRIES INFO
24
Q

What is an axon hillock?

A

JUNCTION of the soma & axon

Where the ACTION POTENTIAL BEGINS

25
Q

What is an axon collateral?

A

BRANCHES of an axon

26
Q

What is a telodendria?

A

END BRANCHES of an axon

27
Q

What is terminal button?

A

KNOB at the tip of an axon

CONVEYS info to other neurons

Aka end foot

28
Q

What is the dendritic spine?

A

PROTRUSION from dendrite

Greatly INCREASES surface area

Usual point of contact w/ axons of other cells

29
Q

What is the synapse?

A

GAP b/w one neuron and the text

Usually between an end foot of the axon of one neuron and a dendritic spine of another neuron

30
Q

What is hyperpolarization?

A

INCREASE in electrical charge across a membrane (MORE NEGATIVE)

DUE to inward flow of CL- or outward flow of K+ ions

31
Q

What is an absolute refractory period?

A

Na+ ion channels are UNRESPONSIVE to FURTHER stimulation

New action potential CANNOT occur

32
Q

What is an relative refractory period?

A

Na+ ion channels COULD support another action potentional, but Na+ K+ channels are STILL OPEN

Only will occur if the stimulation is sufficiently STRONG enough to OVERCOME the charge

33
Q

What is a rate law?

A

Axon encodes stimulus intensity NOT in the size of its a action potential

BUT in its FIRING RATE

34
Q

What are excitatory postsynaptic potentials? (EPSP)

A

When receptors open Na+ channels to produce a PARTIAL DEPOLARIZATION of the dendrites and cell body

35
Q

What are inhibitory postsynaptic potentials? (IPSP)

A

Receptors open K+ channels, Cl- channels, or BOTH to produce a HYPERPOLARIZATION of the dendrites and cell body

36
Q

What is spatial summation?

A

COMBINES potentials occurring stimultaneously at DIFFERENT locations on the dendrites and cell body

37
Q

What is temporal summation?

A

COMBINESv potentials arriving a SHORT TIME APART, from either the SAME or SEPARATE inputs

38
Q

Tay-Sachs disease results from a “__________” allele being expressed, Huntington disease results from a “__________” allele

A

Recessive; dominant

39
Q

What is gene (DNA) methylation?

A

EPIGENETIC mechanism that either enables or blocks transcription

40
Q

What distinguishes Mendelian genetics from epigenetics?

A

Mendelian: focuses on inheritance patterns

Epigenetics: study on how enviro & experience can affect the inherited genome

41
Q

How can the genome of your brain cells change throughout a lifetime?

A
  1. W/in and in the cells environment: epigenetic mechanisms (histone mod., gene methylation, mRNA mod.)
  2. Environmental experiential factors: stress/reduction in stress, changes in brain
42
Q

Glial cells that participate in neuronal growth and repair in the “______” NOT the “_______”

A

PNS; CNS

43
Q

A map of the physical wiring of the entire human brain is called what?

A

Connectome

44
Q

Sensory neurons are the “___________” neuron

A

Simplest