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Flashcards in Chapter 5 Deck (22):
1


Which of the following is NOT entirely a response of the innate immune system?

Antibody mediated complement activation

2


Which of these characteristics are adaptive?

A, B, and C

3

Which of these characteristics are innate?

A, B, and C

4


A mixture of S. aureus and the enteric bacteria E. coli was placed onto the skin of the fingertips of a volunteer. The volunteer immediately touched one of their inoculated fingertips to nutrient agar plate #1 and then waited 30 minutes and touched a different inoculated finger to nutrient agar plate #2. After incubating the plates overnight, what pattern of growth would you expect to see on the plates?

Plate #1 grew both, while plate #2 grew only S. aureus.

5


Where would you be LEAST likely to find significant levels of defensins?

The liver

6

Which of the following is the CORRECT relationship? _______________ on _____________ recognize _________________ on ____________________.


PRRs; macrophages; PAMPs; pathogens

7

Why are many opsonins multimeric?

Because they bind repeating structures on pathogen surfaces

8

Which of the following are associated with damaged or dead cells?

All of the above

9

Which of the following would you predict to result from a mutation in TLR-4 that prevents binding to LPS?

Decreased susceptibility to septic shock

10

Which of the following is NOT usually induced in response to TLR signaling?

IL-4

11


Where would you MOST likely find a TLR that recognizes RNA?

In the endosome/lysosome

12


Which of the following adaptor proteins activate the NF-κB pathway?

MyD88

13

Which cytokine is known for its anti-viral properties?

IFN-α

14


C-reactive protein is a/an:

acute phase response protein.

15


How do natural killer cells kill their targets?

By inducing apoptosis

16


What types of cells are good targets for natural killer cells and why?

Virally infected cells because they have low levels of class I MHC

17

Predict the clinical outcome of a genetic defect in IRAK4, a protein required for the MyD88 pathway.

Increased rates of bacterial infection

18


Activation of dendritic cells with TLR4 or TLR5 results in the production of ________ that induces differentiation of CD4 T cells into __________.

IL-12; TH1

19

Dendritic cells present _____________ antigens on class I MHC through a process known as cross presentation.

exogenous

20

Activation of B cells with TLR rather than with T-cell help would result in the overall antibody response being:

more polyclonal.

21


Which type of vaccine would MOST likely require an adjuvant?

Purified protein

22

Which of the following defenses is MOST likely to protect a plant from a microbial pathogen?

Reactive-oxygen species