Flashcards in Chapter 5 Deck (22):
Which of the following is NOT entirely a response of the innate immune system?
Antibody mediated complement activation
Which of these characteristics are adaptive?
A, B, and C
Which of these characteristics are innate?
A, B, and C
A mixture of S. aureus and the enteric bacteria E. coli was placed onto the skin of the fingertips of a volunteer. The volunteer immediately touched one of their inoculated fingertips to nutrient agar plate #1 and then waited 30 minutes and touched a different inoculated finger to nutrient agar plate #2. After incubating the plates overnight, what pattern of growth would you expect to see on the plates?
Plate #1 grew both, while plate #2 grew only S. aureus.
Where would you be LEAST likely to find significant levels of defensins?
Which of the following is the CORRECT relationship? _______________ on _____________ recognize _________________ on ____________________.
PRRs; macrophages; PAMPs; pathogens
Why are many opsonins multimeric?
Because they bind repeating structures on pathogen surfaces
Which of the following are associated with damaged or dead cells?
All of the above
Which of the following would you predict to result from a mutation in TLR-4 that prevents binding to LPS?
Decreased susceptibility to septic shock
Which of the following is NOT usually induced in response to TLR signaling?
Where would you MOST likely find a TLR that recognizes RNA?
In the endosome/lysosome
Which of the following adaptor proteins activate the NF-κB pathway?
Which cytokine is known for its anti-viral properties?
C-reactive protein is a/an:
acute phase response protein.
How do natural killer cells kill their targets?
By inducing apoptosis
What types of cells are good targets for natural killer cells and why?
Virally infected cells because they have low levels of class I MHC
Predict the clinical outcome of a genetic defect in IRAK4, a protein required for the MyD88 pathway.
Increased rates of bacterial infection
Activation of dendritic cells with TLR4 or TLR5 results in the production of ________ that induces differentiation of CD4 T cells into __________.
Dendritic cells present _____________ antigens on class I MHC through a process known as cross presentation.
Activation of B cells with TLR rather than with T-cell help would result in the overall antibody response being:
Which type of vaccine would MOST likely require an adjuvant?