Chapter 6 Flashcards
proteins
- definition
- play a role in
- 2 functions
- contain what
- made up of
- the predominant structural and functional material in every cell
- every cellular activity
- building, repairing and maintaining cells
- storage, transport and utilization of nutrients that you eat
- building, repairing and maintaining cells
- C H O N
- amino acids
amino acids
- each AA has what 3 things
- what determines proteins function
- how many AA in a chain
- acid group (COOH)
- amine group (NH2)
- side chain (unique)
- 20 unique AA
peptide dipeptide tripeptide polypeptide protein
- <50 AA
- 2 AA
- 3 AA
- > or equal to 10 AA
- > 50 AA
how many essential AA
- can it be made by the body
- where do you get them
- 9
- no
- obtain through diet
how many nonessential AA
-can it be made by the body
- 11
- yes from other AA or by adding N to C - containing structures
conditionally essential AA
under certain conditions, some nonessential AA cannot be synthesized and must be consumed in diet
peptide bond
connects the COOH group of one AA to the NH3 group of another AA
what determines how a protein will fold
AA, their side chains and their interaction with the environment
denaturation
- definition
- what does it do
- ex
- the alteration (unfolding) of protein shapes
- changes structure and function of the protein
- heating egg whites, acidic environment of stomach, mechanical agitation, salt
where are dietary proteins digested and absorbed
in stomach and sm intestine
stomach acids
-2 functions
denature protein and activates pepsin
-breaks down protein into shorter polypeptides
what happens to polypeptides in the sm. intestine
broken down into tripeptides, dipeptides and AA
where are AA absorbed through
sm intestine and enter the blood and travel to liver. proteins are broken down further
AA
-where do they come from (3)
- diet
- breakdown of proteins in body
- a limited supply is stored in AA pools in blood and cells for needed protein synthesis
protein turnover
-process of continuous breakdown and synthesis of protein from its AA
can protein be stored?
no however AA can
AA can be used to make
- 2
- ex
body proteins and non protein substances
-thyroid hormones and melanin
after amine groups are removed what happens to them
-4
- converted to urea and excreted in urine
- burned for energy
- stored as fat
- made into glucose
DNA
- contains what
- component
- instructions for protein synthesis
- gene
gene
DNA segment that codes for specific protein
RNA molecules
- definition
- ex
- carry out instructions for protein synthesis
- mRNA, tRNA
mRNA and tRNA function
perform very specific roles during protein synthesis
sickle cell anemia
- results from
- definition
- what does mutation cause
- from abnormal formation of hemoglobin
- mutation in a gene changes AA sequence in hemoglobin molecule (glutamine to valine)
- causes sickle cell shaped RBCs that are not efficient at carrying O2 and are prone to blood clotting
Phenoketonuria (PKU)
-caused by
abnormal synthesis of phenylalanine hydroxylase