Chapter 6 Flashcards

1
Q

proteins

  • definition
  • play a role in
  • 2 functions
  • contain what
  • made up of
A
  • the predominant structural and functional material in every cell
  • every cellular activity
    1. building, repairing and maintaining cells
      1. storage, transport and utilization of nutrients that you eat
  • C H O N
  • amino acids
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2
Q

amino acids

  • each AA has what 3 things
  • what determines proteins function
  • how many AA in a chain
A
  • acid group (COOH)
  • amine group (NH2)
  • side chain (unique)
  • 20 unique AA
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3
Q
peptide
dipeptide
tripeptide
polypeptide
protein
A
  • <50 AA
  • 2 AA
  • 3 AA
  • > or equal to 10 AA
  • > 50 AA
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4
Q

how many essential AA

  • can it be made by the body
  • where do you get them
A
  • 9
  • no
  • obtain through diet
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5
Q

how many nonessential AA

-can it be made by the body

A
  • 11

- yes from other AA or by adding N to C - containing structures

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6
Q

conditionally essential AA

A

under certain conditions, some nonessential AA cannot be synthesized and must be consumed in diet

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7
Q

peptide bond

A

connects the COOH group of one AA to the NH3 group of another AA

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8
Q

what determines how a protein will fold

A

AA, their side chains and their interaction with the environment

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9
Q

denaturation

  • definition
  • what does it do
  • ex
A
  • the alteration (unfolding) of protein shapes
  • changes structure and function of the protein
  • heating egg whites, acidic environment of stomach, mechanical agitation, salt
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10
Q

where are dietary proteins digested and absorbed

A

in stomach and sm intestine

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11
Q

stomach acids

-2 functions

A

denature protein and activates pepsin

-breaks down protein into shorter polypeptides

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12
Q

what happens to polypeptides in the sm. intestine

A

broken down into tripeptides, dipeptides and AA

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13
Q

where are AA absorbed through

A

sm intestine and enter the blood and travel to liver. proteins are broken down further

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14
Q

AA

-where do they come from (3)

A
  1. diet
  2. breakdown of proteins in body
  3. a limited supply is stored in AA pools in blood and cells for needed protein synthesis
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15
Q

protein turnover

A

-process of continuous breakdown and synthesis of protein from its AA

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16
Q

can protein be stored?

A

no however AA can

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17
Q

AA can be used to make

  • 2
  • ex
A

body proteins and non protein substances

-thyroid hormones and melanin

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18
Q

after amine groups are removed what happens to them

-4

A
  1. converted to urea and excreted in urine
  2. burned for energy
  3. stored as fat
  4. made into glucose
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19
Q

DNA

  • contains what
  • component
A
  • instructions for protein synthesis

- gene

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20
Q

gene

A

DNA segment that codes for specific protein

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21
Q

RNA molecules

  • definition
  • ex
A
  • carry out instructions for protein synthesis

- mRNA, tRNA

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22
Q

mRNA and tRNA function

A

perform very specific roles during protein synthesis

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23
Q

sickle cell anemia

  • results from
  • definition
  • what does mutation cause
A
  • from abnormal formation of hemoglobin
  • mutation in a gene changes AA sequence in hemoglobin molecule (glutamine to valine)
  • causes sickle cell shaped RBCs that are not efficient at carrying O2 and are prone to blood clotting
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24
Q

Phenoketonuria (PKU)

-caused by

A

abnormal synthesis of phenylalanine hydroxylase

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25
phenylalanine hydroxylase
enzyme needed to metabolize phenylaline
26
proteins - 8 functions - used where
- 1. provide structural and mechanical support and help maintain body tissues 2. build enzymes and many hormones 3. help maintain fluid balances by attracting water 4. help maintain acid-base balance 5. transport substances 6. contribute to healthy immune system 7. provide energy 8. improve satiety and appetite control - in muscle contraction (actin and myosin)
27
collagen
a ropelike, fibrous protein that is the most abundant protein in body
28
connective tissue - definition - ex
the most abundant tissue type in body | -bones, tendons, ligaments
29
transport proteins | -function
shuttle O2, waste products, lipids, some vitamins and sodium and potassium through your blood and into and out of cells through cell membranes
30
antibodies - definition - what creates antibodies - provides what
- proteins that eliminate potentially harmful substances - the body creates antibodies against pathogens and stores that info - immunity against subsequent exposure
31
what proteins improve satiety and appetite control
ghrelin, leptin and cholecystokinin
32
what should healthy adults be in
nitrogen balance
33
nitrogen balance
amount of N consumed in dietary protein = amount excreted in urine
34
nitrogen imbalances | -2 types
- positive nitrogen balance | - negative nitrogen balance
35
positive nitrogen balance - definition - what do bodies do - ex
- more N is retained (for protein synthesis) than is excreted - Bodies need to hold onto N to build new tissues - infants, children, pregnant women
36
negative nitrogen balance - definition - what do bodies do - ex
- more N is excreted than consumed (body proteins are broken down) - bodies are breaking down more protein than is consumed - starvation, serious injury or illness
37
complete proteins - contains what - low or high quality protein - sources
contains all essential AA plus some non essential AA - high quality - soy, quinoa, and animal protein
38
incomplete proteins - definition - low or high quality - sources
- low in 1 or more essential AA - low - plant foods, gelatin
39
limiting AA
AA found in shortest supply is an incomplete protein
40
what are plant proteins upgraded to ____ by 2 things
1. consuming modest amounts of soy or animal protein | 2. protein complementation
41
protein complementation - definition - ex
- being complemented with other plant proteins that provide enough of the limiting AA - rice and beans
42
protein digestibility corrected amino acid score (PDCAAS) - definition - basis of what - ex. - if you ate only milkwould you meet all of your AA needs?
- measure of protein quality taking into account digestibility and AA profile - basis of protein as % DV on food labels - milk protein, chickpeas, and wheat - yes
43
milk protein PDCAAS of.. - chickpeas - wheat
- 100% - 87% is digestible - 44%
44
protein recommedations - average intake in the US; why? - ____ of body weight needed daily (>18 yo)
- 10-35% of total daily calories - 15%, because we are consuming more calories as fat and carbs - 0.8g of protein/kg
45
calculating your daily protein needs | -ex
convert weight from lbs to kg by dividing by 2.2 then multiplying by .8 -130lb divided by 2.2 = 59; 59 x .8 = 47
46
how much more protein do ___ need? - pregnant women - infants - infants (1-3 yo) - infants (4-13)
- 1.1 g/kg - 1.5 g/kg - 1.1 g/kg - 0.9 g/kg
47
protein shakes and powder - made of what - contain
- whey, soy or rice protein | - unwanted additives
48
amino acid supplements - sold as - may have what type of effects
- remedies for various health issues | - negative effects
49
protein and energy bars
convienient, but expensive and high in calories
50
eating to much protein - risks - generates what - what should you consume - can displace what - associated with what
- increase risk of heart disease, kidney stones, calcium loss from bones - acid: body responds by releasing calcium from bones - foods rich in potassium or calcium - other nutrient and fiber rich foods - a reduced risk of chronic disease
51
eating to little protein - may lead to what - risks
- -reduction of lean body mass, especially in older adults | - increased risk of fratility, impaired healing, and decreased immune function
52
protein -energy malnutrition (PEM) - definition - more common in - factors
- inadequate calories and/or protein - children because they are growing - poverty, stopping lactation
53
kwashiorkor - definition - signs - seen in where - translated to
- severe deficiency of dietary protein - edema, muscle loss, skin rashes, hair changes, water and electrolyte imbalances - children weaned to low-protein cereals - the sickness the baby gets when the new baby is born
54
marasmus - definition - signs
- severe deficiency of calories | - emanciation, lack of growth, loss of fat stores
55
marasmic - kwashiorkor | -definition
worst of both conditions
56
how to treat protein deficiency diseases
medical treatment, food and water (3 step approach)
57
vegetarians meet protein needs by consuming | -2
1. variety of plant foods | 2. protein rich meat alternatives
58
protein rich meat alternatives | -5
1. soy 2. quinoa 3. dried beans and other legumes 4. nuts 5. eggs, dairy (lacto-ovo-vegetarians)
59
vegetarian - 2 benefits - risk
- 1. may reduce risk of heart disease, high BP, diabetes, cancer, stroke and obesity 2. food staples are rich in fiber and low in saturated fat and cholesterol - potential deficiencies of nutrients found in animal foods
60
benefits of soy
1. high quality protein source 2. low in saturated fat and 0 cholesterol 3. contains isoflavones (phytoestrogen) 4. lowers blood cholesterol levels 5. may reduce risk of heart disease and certain cancers