Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BMSC 200 > Chapter 9 > Flashcards

Chapter 9 Flashcards

1
Q

micelle

A

cone shaped, head greater than tail

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

bilayer

A

cylindrical, head equals tail

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

liposome

A

folded bilayer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

cellular membranes consists of….

A
  • lipids

- membrane proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Bimolecular reactions in membrane are more efficient than in….

A

solution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Probability of molecular collision in 2D plane is _______ than in 3D space.

A

higher

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

flippases

A

catalyze translocation of lipids from one side of bilayer to the other

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

uncatalyzed translocation of lipids from one side of bilayer to the other is….

A

slow af

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

below phase transition temperature, the membrane is…

A

in ordered paracrystalline state

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

at temperatures above phase transition, membrane is….

A

fluid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

___________ is important for function

A

fluidity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

______________ of the phospholipids is adjusted for proper membrane fluidity.

A

fatty acid composition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

lipid raft

A

sphingolipids and cholesterol clustered together

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

lipid rafts are stabilized by…

A

interactions between the cholesterol ring and one saturated hydrocarbon tails of sphingolipids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

lipids rafts function

A

attachment points for peripheral membrane proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

how do lipid rafts and membrane proteins attach?

A

two covalently attached saturated acyl chains or glycosylated phosphoinositol derivatives (GPI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

intergral membrane proteins

A

usually span the bilayer with parts exposed on both sides; can be extracted with detergents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

peripheral membrane proteins

A

most in cytosol or extracellular space, some attached to membrane (non-covalent interaction or lipid anchors)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

proteins anchored to membrane by GPI are….

A

always outside the cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

proteins anchored by fatty acyl or prenyl chains are ….

A

always inside the cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

in intergral membrane proteins, charged residues are located mostly…

A

outside the membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

residues with _____________ dominate the inside

A

apolar side chains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

a-helical bundle

A

7 helices bonded together

24
Q

B-barrel

A

22 strands closing on itself (1 H bond…?)

25
Q

the __________ in the hydrophobic core of bilayer _______ regular secondary structures.

A

apolar environment, stabilizes

26
Q

membrane fusion

A

membrane vesicles that exist in cells fusing with plasma membrane and themselves (exocytosis, endocytosis, fusion of sperm and egg, cell division)

27
Q

How can a neutron cross the junction?

A

membrane vesicles full of Ace released to synaptic cleft, diffuse, interact with receptors, which serve as signal to open

28
Q

free energy equation for diffusion with both concentration and electric component

A

deltaG=-mFdeltaΨ +2.3RTlog[Cin]/[Cout]

29
Q

electric potential different favours movement of _ charge ions from _____ to _______

A

+, outside to inside

30
Q

electric potential different favours movement of _ charge ions from _____ to _______

A

+, outside to inside

31
Q

deltaG<0

A

favourable

32
Q

deltaG>o

A

unfavourable

33
Q

primary active transport

A

against electrochemical gradient

34
Q

secondary active transport

A

against electrochemical gradient, driven by ion moving down its gradient

35
Q

passive transport

A

transport down electrochemical gradient

36
Q

channels

A

can only transport molecules and ions down the electro gradient

37
Q

rate of transport though channel is ….

A

proportional to substrate concentration

38
Q

carriers

A

can catalyze both active and passive transport

-generally lower rate of transport than channels due to rate limiting step

39
Q

glucose transporter carrier equation

A

Vo=(Vmax[S]out)/(Kt+[S]out)

40
Q

polar side chins form __________ with glucose in transporter interior

A

hydrogen bonds

41
Q

uniport

A

passive carriers of one substrate

42
Q

symport

A

2 substrates in same direction

43
Q

antiport

A

2 substrate in opposite direction

44
Q

electroneutral

A

no net charge flow

45
Q

electrogenic

A

transports 1 charge across membrane

46
Q

ATP hydrolysis is…

A

highly exergonic reaction

47
Q

primary active transporters powered by ATP hydrolysis

A

Na+, K+, -ATPase

48
Q

large scale domain movement are involved in ion transport by…

A

Ca+2-ATPase

49
Q

which allow greater freedom of movement… a-helical or B-barrel?

A

a-helical

50
Q

ATP synthase

A

convert energy of proton gradient to make ATP

-reversible

51
Q

secondary active transporters operate by..

A

rocket switch mechanism

52
Q

how does the rocket switch mechanism operate

A

exposing the binding site from cytoplasm (state I) to extracellular space (state II) is triggered by protonation and deprotonation of charged residues in the interior

53
Q

transition between two states in rocket switch mechanism requires…

A

binding affinity of state I to be lower than state II

54
Q

Na+K+ ATPase hydrolyzes ATP and that energy is …

A

used to pump sodium ions out of the cell and potassium ions in

55
Q

3 important properties of protein ion channels

A
  • high conduction rates
  • selectivity
  • gating

BMSC 200 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions