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Pharm 233 Final > Chemotherapy > Flashcards

Chemotherapy Flashcards

(52 cards)

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1
Q

Cyclophosphamide

A

Nitrogen mustard

Alkylating agent

Treatment of breast cancer and lymphoma

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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2
Q

Procabazine

A

Triazine/Tetrazine

Alkylating agent

Treatment of lymphoma

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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3
Q

Cisplatin

A

Platinum

Alkylating agent

Treatment of lung cancer

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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4
Q

Carboplatin

A

Platinum

Alkylating agent

Treatment of lung cancer

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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5
Q

Oxaliplatin

A

Platinum

Alkylating agent

Treatment of colon cancer

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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6
Q

Methotrexate

A

Antimetabolite

Prevents the synthesis of purine nucleotides and thymidylate

Treatment of leukemia

Bone marrow toxicity
Damage to the epithelium of the GI tract

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7
Q

Fluorouracil

A

Antimetabolite

Increases levels of dUMP and causes DNA damage

Treatment of colon and breast cancers

Bone marrow toxicity
Damage to the epithelium of the GI tract

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8
Q

Cytarabine

A

Antimetabolite

Inhibition of DNA polymerase

Treatment of leukemia

Bone marrow toxicity
Damage to the epithelium of the GI tract

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9
Q

Mercaptopurine

A

Antimetabolite

Blocks or subverts DNA synthesis

Treatment of leukemia

Bone marrow toxicity
Damage to the epithelium of the GI tract

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10
Q

Capecitabine

A

Antimetabolite

Blocks or subverts DNA synthesis

Treatment of colon and breast cancers

Bone marrow toxicity
Damage to the epithelium of the GI tract

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11
Q

Gemcitabine

A

Antimetabolite

Blocks or subverts DNA synthesis

Treatment of lung cancer

Bone marrow toxicity
Damage to the epithelium of the GI tract

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12
Q

Pemetrexed

A

Antimetabolite

Blocks or subverts DNA synthesis

Treatment of lung cancer

Bone marrow toxicity
Damage to the epithelium of the GI tract

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13
Q

Doxorubicin

A

Anthracycline - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of breast cancer and lymphoma

Cardiotoxicity
Alopecia

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14
Q

Idarubicin

A

Anthracycline - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of leukemia

Cardiotoxicity
Alopecia

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15
Q

Epirubicin

A

Anthracycline - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of breast cancer

Cardiotoxicity
Alopecia

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16
Q

Etoposide

A

Plant-based compound

Epipodophyllotoxin - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of lung cancer and lymphoma

Bone marrow suppression
Cardiotoxicity
Alopecia

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17
Q

Irinotecan

A

Camptothecin derivative - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of colon cancer

Cardiotoxicity
Alopecia

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18
Q

Paclitaxel

A

Plant-based compound

Acts on microtubules, freezing them in a polymerized state resulting in cell cycle arrest and apoptosis

Bone marrow suppression
Neurotoxicity

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19
Q

Prednisolone

A

Glucocorticoid

Inhibits lymphocyte proliferation

Treatment of leukemias and lymphomas

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20
Q

Tamoxifen

A

Antiestrogen

Treatment of hormone-dependent breast cancer

Blocks estrogen-responsive genes

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21
Q

Flutamide

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A

Antiandrogen

Treatment of prostate tumors

22
Q

Cyproterone

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A

Antiandrogen

Treatment of prostate tumors

23
Q

Bicalutamide

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A

Antiandrogen

Treatment of prostate tumors

24
Q

Anastrozole

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A

Aromatase inhibitor

Suppress synthesis of estrogen from androgens

Treatment of breast cancer in postmenopausal women

25
Letrozole
Aromatase inhibitor Suppress synthesis of estrogen from androgens Treatment of breast cancer in postmenopausal women
26
Exemestane
Aromatase inhibitor Suppress synthesis of estrogen from androgens Treatment of breast cancer in postmenopausal women
27
Vincristine
Vinca alkaloid Antimicrotubule Used in combination with hormone treatments Treatment of lymphoma and breast cancer
28
Vinblastine
Vinca alkaloid Antimicrotubule Used in combination with hormone treatments Treatment of lymphoma
29
Vinorelbine
Vinca alkaloid Antimicrotubule Used in combination with hormone treatments Treatment of breast and lung cancer
30
Paclitaxel
Taxane Antimicrotubule Used in combination with hormone treatments Treatment of breast and lung cancer
31
Docetaxel
Taxane Antimicrotubule Used in combination with hormone treatments Treatment of breast and prostate cancer
32
Nab-paclitaxel
Taxane Antimicrotubule Used in combination with hormone treatments Treatment of breast cancer
33
Rituximab
mAB Binds to CD20 Treatment of lymphoma, including Hodgkins Hypotension Chills and fevers
34
Trastuzumab
Aka Herceptin mAB Inhibits oncogenic receptor HER2 Treatment of HER2+ breast cancer Hypotension Chills and fevers Cardiotoxicity (suppression, not loss, therefore reversible)
35
Bevacizumab
mAB Neutralizes VEGF (angiogenesis) Treatment of colorectal cancer Hypotension Chills and fevers
36
Catumaxomab
mAB Binds EpCAM, which is overexpressed in some malignant cells and activates immune cells to clear cancer cells Hypotension Chills and fevers
37
Imatinib
Protein kinase inhibitor Great for treatment of leukemia Binds a cancer-specific protein, but also other targets and inhibits other body/cell functions
38
Erlotinib
Protein kinase inhibitor Targets EGFR Treatment of non-small cell lung and pancreatic cancer GI symptoms Fatigue Headaches Cardiotoxicity
39
Sorafenib
Protein kinase inhibitor Targets several tyrosine-kinase receptors
40
Gefitinib
Protein kinase inhibitor Targets EGFR Treatment of lung cancer GI symptoms Fatigue Headaches Cardiotoxicity
41
Afatinib
Protein kinase inhibitor Targets EGFR Treatment of lung cancer GI symptoms Fatigue Headaches Cardiotoxicity
42
Osimertinib
Protein kinase inhibitor Targets EGFR Treatment of lung cancer GI symptoms Fatigue Headaches Cardiotoxicity
43
Cetuximab
mAB Targets EGFR Treatment of colon cancer GI symptoms Fatigue Headaches Cardiotoxicity
44
Panitumumab
mAB Targets EGFR Treatment of colon cancer GI symptoms Fatigue Headaches Cardiotoxicity
45
Hydroxyurea
Treatment of leukemia
46
Bleomycin
Treatment of lymphoma
47
Asparaginase
Treatment of leukemia
48
Nivolumab
PD-1/PD-L1 inhibitor mAB Treatment of lung cancer
49
Pembrolizumab
PD-1/PD-L1 inhibitor mAB Treatment of lung cancer
50
Atezolizumab
PD-1/PD-L1 inhibitor mAB Treatment of lung cancer
51
Durvalumab
PD-1/PD-L1 inhibitor mAB Treatment of several cancers
52
Ipilimumab
CTLA4 inhibitor mAB Treatment of several cancers

Pharm 233 Final (11 decks)

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