HBV Flashcards
1
Q
Adefovir
A
Used for HBV, works on HIV, HSV, and CMV
Phosphorylated twice and incorporated into DNA causing termination
2
Q
Tenofovir
A
dAMP analog
First line chronic HBV, PrEP
Inhibits protein priming and DNA synthesis
3
Q
Entecavir
A
dGMP analog
First line chronic HBV
Inhibits HBV DNA polymerase
4
Q
Ribavirin
A
Nucleoside analog
Phosphorylated thrice and interferes with mRNA elongation, monophosphate inhibits IMP dehydrogenase (GTP synthesis)
5
Q
Boceprevir
A
Toxic and removed from market
Protease inhibitor for HCV
6
Q
Telaprevir
A
Toxic and removed from market
Protease inhibitor for HCV
7
Q
Grazoprevir
A
NS3/4A protease inhibitors
HCV (?)
8
Q
Simeprevir
A
NS3/4A protease inhibitors
HCV (?)
9
Q
Sofosbuvir
A
RNA polymerase inhibitor, competes with uridine
