Influenza

Question 1

Amantadine

Answer 1

Inhibits proton channel function of influenza A M2 matrix protein, required for decapsidation

Resistance through mutations to the M2 channel

Question 2

Rimantadine

Answer 2

Inhibits proton channel function of influenza A M2 matrix protein, required for decapsidation

Resistance through mutations to the M2 channel

Question 3

Oseltamivir

Answer 3

Aka Tamiflu

Inhibits viral neuraminidase, preventing release of virus, active against influenza A and B

Resistance through mutations in neuraminidase enzyme

Question 4

Zanamivir

Answer 4

Aka Relenza

Sialic acid analog, inhibits viral neuraminidase through competition, preventing release of virus, active against influenza A and B and in oseltamivir-resistant strains

Question 5

Peramivir

Answer 5

Aka RAPIVAB

Neuraminidase inhibitor

Treatment of influenza A and B

Question 6

Xofluza

Answer 6

Inhibits mRNA replication of influenza virus through inhibition of endonuclease function of viral PA polymerase (snatch and grab inhibitor)

Question 7

Remdesivir

Answer 7

Originally designed for Ebola, RSV

Triphosphate inhibits RNA dependent RNA polymerase

Treatment of MERS (other coronaviruses?)

Question 8

Molnupiravir

Answer 8

Causes a G-to-A mutation in the viral genome through tautomerization of molecule

Not approved in Canada

Treatment of coronaviruses

Question 9

Paxlovid

Answer 9

Combination of nirmatrelvir (peptidomimetic protease inhibitor) and ritonavir (mainly an enhancer, but also a protease inhibitor)

Coronavirus treatment