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Flashcards in Chemotherapy Deck (30):
1

How many cells must be in a tumour before it can be physically detected?

10^9

2

In what cases in curative chemotherapy used

Solid tumours

3

What is meant by each letter in the TMN score

T= tumour- local mass and extension
N= nodes- has it reached nodes
M= metastasis- has it spread systemically

4

What is the purpose of adjuvant chemotherapy

To eridicate or control micro-metastasis

5

What are the 3 functions of neo-adjuvant chemotherapy

To make surgery or RT possible
To alleviate surgical damage
To eradicate micro-metastasis

6

In what malignancies is chemotherapy the primary treatment

Haematological malignancies

7

Define 'specific cell cycle phase drug'
What does its action depend upon?

Agents with major activity in particular phase of cycle
Schedule dependent

8

Define 'non specific cell cycle phase drug'
What does its action depend upon?

Agents with significant activity in multiple phases
Dose dependent

9

Name 5 non phase specific drugs

- Cyclophosphamide
- Chlorambucil
- Cisplatin
- Actinomycin- D
- L- asparaginase

10

Name a drug that acts in the G1 phase

Vinblastine

11

Name a drug that acts in the S phase (3)

Methotrexate
6-Mercaptopurine
5-Fluorouracil

12

Name the drugs that act in G2 phase v(4)

Bleomycin
Etoposide
Topotecan
Daunorubicin

13

Name the drugs that act in the M phase (4)

Vincristine
Vinblastine
Paclitaxel
Docetaxel

14

Where do antimetabolites act?

At DNA synthesis

15

Where do alkylating agents act

Directly upon the DNA

16

Where do intercalating agents act

At DNA transcription and DNA duplication

17

Where do spindle poisons act

Mitosis

18

How do drugs act indirectly

By altering the hormonal mileau

19

Name some examples of indirectly acting dryugs (5)

- Corticosteroid
- Oestrogens
- 5 alpha reductase inhibitor
- Gnrh agonist
- Progestins

20

Give some examples of directly acting cytotoxic drugs (3)

Alkylating agents
Antimetabolites
Natural products

21

Give some examples of natural products with cytotoxic properties

Antibiotics
Vinca alkaloids
Taxanes
Epipodophyllotoxins
Camptothecin analogs
Enzymes
BIological response modifers

22

5 types of drugs that are classified as alkylating agents

- Nitrogen Mustards
Ethyleneimine
Alkyl Sulfonate
Nitrosureas
Triazines

23

3 types of drugs that are classified as antimetabolites

- Folate antagonists
- Purine antagonists
- Pyrimidine antagonists

24

What are vinca alkaloids obtained from

Vinca Rosea

25

Name 4 vinca alkaloids

Vincristine
Vinblastine
Vindesine
Vinorelbine

26

What are taxanes obtained fromq

Pacific Yew or European Yew

27

Name 2 taxanes

Paclitaxel and docetaxel

28

Name 6 drugs which are used to treat cancer but are known as 'miscellaneous agents'

Cisplatin
Carboplatin
Hydroxurea
Procarbazine
Mitotane
Imatinib

29

How long does chemo treatment usually last

6 months in 2-4 weekly cycles

30

Side effects of chemo

Tiredness, nausea, vomiting, hair loss, infection, infertility