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Flashcards in Targeted Therapy Deck (26):
1

Name the 5 basic classes of antineoplastic drugs

Alkylating agents
Antimetabolites
Plant alkaloids
Hormone and antagonists
Targeted Therapy

2

Name 3 alkylating agents

Melphalan
Chlorambucil
Cyclophosphamide

3

Name an antimetabolite

Methotrexate

4

Name 2 plant alkaloids

Taxanes
Vinca alkaloids

5

Name 2 hormones and antagonists

Anti-oestrogens
Anti-androgens

6

Name 2 targeted therapies

Monoclonal antibodies
Small tyrosine kinase inhibitors

7

What are the 2 best targets for cancer therapy

1- found in cancer cells but not normal
2- more targets in cancer than normal (eg gene amplification)

8

Define targeted cancer therapies

Drugs or other substances that block the growth and spread of cancer by interfering with specific molecules involved in tumour growth and progression

9

Name 2 intracellular pathways signalled by tyrosine kinases

P13 kinase pathway
MAPK pathway

10

Describe the action of antibodu of inhibitors of growth receptors

Bind to growth factors receptor and prevent growth signal

11

Describe the action of antibody-drug conjugatres

Targets drug to tumour cells

12

What syllable do all monoclonal antibodies end in

mab

13

What does it mean if the next to last syllable of a mab is u

Human

14

What does it mean if the next to last syllable of a mab is zu

Humanised

15

What does it mean if the next to last syllable is xi

Chimeric

16

What does it mean if the next to last syllable is o, a, e and u

o= mouse
a= rat
e= hampster
i= primate

17

How do drugs that target growth factor receptors work?

Inhibits growth factor signalling that is mediated with tyrosine kinase
Results in arrest in tumour growth

18

Name 2 drugs that target epidermal growth factor receptor

Cetuximab
Panitumumab

19

Name a drug that targets HER2 (ErbB2)

Trastuzumab

20

Name a drug that targets HER3

Pertuzumab

21

Name a drug that targets vascular endothelial growth factor receptor

Bevacizumab

22

How do antibodies access tumour cells

Vessels are leaky so small and large molecules can access tissue
Tumour tissue doesn't have lymphatic drainage so macromolecules are retained

23

How do some monoclonal antibodies kill the tumour cell directly

Signalling blocked
Apoptosis induced
Possible delivery of toxic payload

24

How do monocloonal antibodies kill tumour cells via immune mediated mechanism

Induce phagocytosis
Complement dependent cytotoxicity
Antibody dependent cell cytotoxicity

25

How do monoclonal antibodies work by vascular or stromal ablation

Possible delivery of toxic payload
VEGF antagonism

26

In what percentage of breast cancers overexpress HER2

15%