Chemotherapy Induced Nausea

Question 1

What are the 3 main classes of medications used to treat Chemotherapy-induced nausea?

Answer 1

5HT inhibitors
NK-1 Antagonists
Glucocorticoids

all 3 can be combined

Question 2

What are common 5-HT inhibitors?

Answer 2

Ondansetron, Granisetron, Palonosetron, Dolasetron

Question 3

What is the best initial therapy for Chemotherapy induced nausea?

Answer 3

5HT inhibitors

Question 4

What are 5HT inhibitors contraindicated?

Answer 4

QT prolongation

Question 5

What are common Glucocorticoids used for Chemotherapy-induced nausea?

Answer 5

Dexamethasone

Question 6

What do Glucocorticoids need to be effective against chemotherapy-induced nausea?

Answer 6

Combination with 5HT inhibitors

Question 7

What are common NK receptor antagonists?

Answer 7

Aprepitant, Rolapitant, Netupitant

Question 8

What do you use for chemotherapy induced nausea if 5HT inhibitors do not work or cannot be given due to QT prolongation?

Answer 8

NK-Receptor antagonists