Childhood disease III Flashcards Preview

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Flashcards in Childhood disease III Deck (12)
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1
Q

What type of transloaction results in infantile fibrosarcoma?

A

ETV6-TRKC gene via 12;15 transloaction.

2
Q

What is a tumor marker for congenital infantile fibrosarcoma?

A

ETV6-TRKC

3
Q

what is the incedence of teratoma?

A

1/20,000 - 40,000 live births

4
Q

What is the most common solid tumor in the newborn?

A

acrococcygeal teratoma

5
Q

What is the most common solid congenital malignancy?

A

Congenital neuroblastoma.

6
Q

What oncogene is associated with neuroblastoma?

A

N-myc

7
Q

Urine vanillylmandelic acid and homovanillic acid are markers for what condition?

A

Neuroblastoma.

8
Q

“Small blue round cells with rosette structure and dense core neurosecretory granules”

A

Neuroblastoma

9
Q

What is most common primary malignant tumor of kidney and what is its incidence?

A

Wilms tumor with an incidence of 1/10,000

10
Q

Wilms tumor is associated with inactivation of what?

A

WT1 and WT2

11
Q

Rhabdomyosarccoma

A

Tends to go to the neck and eyes

accounts for 5-8% malignancy

12
Q

What type of rhabdomyosarcoma is most common?

A

Embryonal rhabdomyosarcoma 60% followed by:

Alveolar rhabdomyosarcoma
and
Pleomorphic rhabdomyosarcoma (worst)