Flashcards in Childhood Diseases 1 Deck (22):
No 1 cause of death in children younger than 1 year old?
Incidence of congenital anomalies?
What are the top four most common congenital anomalies in descending order?
Patent ductus arteriosis
Ventricular Septal defect
Way at bottom is rectal and intestinal atresia.
Incidence of Trisomy 21?
Most common chromosomal disorder and leading cause of mental retardation in the US?
Trisomy 21 patients are at 10-20 times higher risk of developing?
ALL and AML
Acute megakaryoblastic anemia.
When are the triplicate and quad screens for Downsyndrome offered?
What does the triplicate DS screen for?
75% detection rate checking serum AFP, estriol and B-hCG
What does the Quad screen DS test for?
79% detection rate measuring serum AFP,Estriol, BHCG just like the triplicate but adds test for inhibin alpha.
What does the AFP/ free beta screen test for in DS?
Performed at 13-22 weeks testing for AFP and free B-HCG with a 80% detection rate.
At what period of time can nuchal translucency be used for DS detection?
10-13.5 weeks with a 91% detection rate!!
Also looks for free B-HcG and PAPPA (Pregnancy associated plasma protein A)
What is the incedence of Cystic Fibrosis?
The most common mutation causing CF leads to a deletion of what?
3 nucleotides coding for phenylalanine at A.A. position 508.
At what age will a neonate be considered premature?
When born before 37 weeks.
Post term if born >42 weeks
What Heart Rate is a 2 for the APGAR score?
What APGAR score correlates to 0% chance of immediate death?
APGAR score >7
What apgar score correlates with a 20% chance at immediate death?
APGAR score of 4
What is the number 2 cause of death in children younger than 1 year?
Asymetric Fetal Growth Restriction is seen at what stage compared to Symmetric Fetal Growth Restriction?
Asymetric = Placental abnormalities
Symetric = Fetal abnormalities
When does Rubella invade the placenta?
During the first trimester with 10% incedence fetal infection
Leads to rash, microcephaly, heart defects, and cataracts.
When does Congenital syphillis cross the placenta?
5th months of pregnancy making prevention easy!
Still birth in 1/3
2/3 of carried fetus have congenital syph.