Childhood Diseases 1 Flashcards Preview

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Flashcards in Childhood Diseases 1 Deck (22):
1

No 1 cause of death in children younger than 1 year old?

Congenital anomalies

2

Incidence of congenital anomalies?

1/33

3

What are the top four most common congenital anomalies in descending order?

Club Foot
Patent ductus arteriosis
Ventricular Septal defect
Cleft Lip



Way at bottom is rectal and intestinal atresia.

4

Incidence of Trisomy 21?

1/700 births

5

Most common chromosomal disorder and leading cause of mental retardation in the US?

Trisomy 21

6

Trisomy 21 patients are at 10-20 times higher risk of developing?

ALL and AML
Acute megakaryoblastic anemia.

7

When are the triplicate and quad screens for Downsyndrome offered?

Weeks 15-20

8

What does the triplicate DS screen for?

75% detection rate checking serum AFP, estriol and B-hCG

9

What does the Quad screen DS test for?

79% detection rate measuring serum AFP,Estriol, BHCG just like the triplicate but adds test for inhibin alpha.

10

What does the AFP/ free beta screen test for in DS?

Performed at 13-22 weeks testing for AFP and free B-HCG with a 80% detection rate.

11

At what period of time can nuchal translucency be used for DS detection?

10-13.5 weeks with a 91% detection rate!!

Also looks for free B-HcG and PAPPA (Pregnancy associated plasma protein A)

12

What is the incedence of Cystic Fibrosis?

1/2500

13

The most common mutation causing CF leads to a deletion of what?

3 nucleotides coding for phenylalanine at A.A. position 508.

14

At what age will a neonate be considered premature?

When born before 37 weeks.

Post term if born >42 weeks

15

What Heart Rate is a 2 for the APGAR score?

>100

16

What APGAR score correlates to 0% chance of immediate death?

APGAR score >7

17

What apgar score correlates with a 20% chance at immediate death?

APGAR score of 4

18

What is the number 2 cause of death in children younger than 1 year?

PRemature birth

19

Asymetric Fetal Growth Restriction is seen at what stage compared to Symmetric Fetal Growth Restriction?

Asymetric = Placental abnormalities

Symetric = Fetal abnormalities

20

When does Rubella invade the placenta?

During the first trimester with 10% incedence fetal infection
Leads to rash, microcephaly, heart defects, and cataracts.

21

When does Congenital syphillis cross the placenta?

5th months of pregnancy making prevention easy!

Still birth in 1/3
2/3 of carried fetus have congenital syph.

22

Hutchinsons teeth, mulberry molars and saber teeth are all identifying conditions of what disease?

Congenital syphilis.