Immuno Path V - Immuno Def. cont'd Flashcards Preview

Real Path Exam III > Immuno Path V - Immuno Def. cont'd > Flashcards

Flashcards in Immuno Path V - Immuno Def. cont'd Deck (13)
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1
Q

What genetic defect is commonly seen in Wiskott-Aldrich Syndrome?

A

X-linked disorder of male infants
defect in WASP gene responsible for signal transduction and cytoskeleton maitenace.

**Lack of CD43 cytoskeleton glycoprotein.

2
Q

What is a clinical sign of Wiskott-Aldrich syndrome?

A

Impairs both cellular and humoral.

Lack of response to polysaccharide Ag in bacterial cell walls due to low IgM.

3
Q

A CD4 count of what indicates full blown AIDS?

A
4
Q

What cellular HIV component binds to CD4 cells?

A

Gp120 on the virus binds to CD4 molecule CCR5 (macrophages) and CxCR4 (T cells)

Then taken up by gp 41 expression.

5
Q

This HIV gene is impairative for its infectivity

A

nef

6
Q

What serum factor will be found in patients suffering from amyloidosis?

A

Serum amyloid-P

7
Q

Amyloid will stain in what manner?

A

Congo red with polarized light will show up apple green!

8
Q

What configuration are the fibrils in when having amyloidosis?

A

B-Pleated sheets.

9
Q

Amyloid light chain type is derived from what type of cells?

A

Derived from plasma cells with frequent involvement of the heart, GIT, peripheral nerves, skin and tongue.

10
Q

Amyloid associated type Amyloidosis is related to what?

A

Derived from serum amyloid associated protein (SAA) which is an acute phase protein from the liver.

Most commonly seen in RA, IBD, and Hodgkins lymphoma.

11
Q

What does ATTR (Amyloid transthyretin) cause?

A

Amyloid transthyretin related to senile cardiac amyloid.

12
Q

What does Amyloid beta cause?

A

Found in Alzheimers

13
Q

AB 2 microglobulin protein (Amyloid) is found in what?

A

Normal component of MHC class I