Flashcards in Immuno Path V - Immuno Def. cont'd Deck (13):
What genetic defect is commonly seen in Wiskott-Aldrich Syndrome?
X-linked disorder of male infants
defect in WASP gene responsible for signal transduction and cytoskeleton maitenace.
**Lack of CD43 cytoskeleton glycoprotein.
What is a clinical sign of Wiskott-Aldrich syndrome?
Impairs both cellular and humoral.
Lack of response to polysaccharide Ag in bacterial cell walls due to low IgM.
A CD4 count of what indicates full blown AIDS?
What cellular HIV component binds to CD4 cells?
Gp120 on the virus binds to CD4 molecule CCR5 (macrophages) and CxCR4 (T cells)
Then taken up by gp 41 expression.
This HIV gene is impairative for its infectivity
What serum factor will be found in patients suffering from amyloidosis?
Amyloid will stain in what manner?
Congo red with polarized light will show up apple green!
What configuration are the fibrils in when having amyloidosis?
Amyloid light chain type is derived from what type of cells?
Derived from plasma cells with frequent involvement of the heart, GIT, peripheral nerves, skin and tongue.
Amyloid associated type Amyloidosis is related to what?
Derived from serum amyloid associated protein (SAA) which is an acute phase protein from the liver.
Most commonly seen in RA, IBD, and Hodgkins lymphoma.
What does ATTR (Amyloid transthyretin) cause?
Amyloid transthyretin related to senile cardiac amyloid.
What does Amyloid beta cause?
Found in Alzheimers