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Flashcards in Chlamydia Deck (40):
1

why is chlamydia an obligate intracellular pathogen

cannot make ATP and thus depends on host cell ATP

2

describe two stages of chlamydia life cycle

elementary bodies- small, non multiplying w/ rigid cell wall. transmits infection from cell to cell or person to person

initial bodies (reticulate bodies)- larger, actively multiplyng, lacks rigid wall, non infectious

3

describe gram stain of chlamydia

gram indeterminant

4

describe the intracellular growth cycle of chlamydia

elementary bodies enter by phagocytosis (can enter not phagocytotic)

during 1st 24 hours, elementary bodies lose cell walls and become initial bodies

binary fission occurs. some progeny revert back to elementary bodies

5

3 classifications of chlamydia

chlamydphilia psittaci- causes psittiacosis- 1 serotype

chlamydophilia pneumoniae- causes pneumonia- 1 serotype

chlamydia trachmatis- many serotypes- trachoma, lymphogranuloma, pneumonia, urethritis

6

chlamydophilia psittaci infection

parasite of birds- causes subclinical infection w/ constant fecal excretion

humans acquire by inhaling bird feces

7

chlamydophilia psittaci symptoms

can travel in the blood- causes fever and headache- causes interstitial pneumonia

8

chlamydophilia pneumonia causes....

causes significant portion of pneumonia in adults

atypical pneumonia

9

chlamydophilia pneumonia transmission

spread person to person w/ respiratory aerosols

10

chlamydophilia pneumonia is associated w/ what other disease

atherosclerosis

11

chlamydia trachomatis D-K causes...

nongonococcal urethritis

many males are asymptomatic. disease causes purulent urethral discharge

increases liklihood of HIV b/c it draws immune cells into genital areas

12

complications of chlamydia trachomatis nongonoccal urethritis

sometimes causes more serious disease involving epididimus or fallopian tubes

can cause sterlility or ectotopic pregnancy

13

chlamydia trachomatis D-K in infants

infected women (symptomsatic or no) give birth to child and child gets inclusion conjunctivitis

could also cause chlamydia pneumonia

in adults, inclusion conjunctivits can be an STD

14

chlamydia trachomatis trachoma

causes by serotypes A B C

eye infection- mechanical transmission (finger to eye or flies in the eyes)

chronic reinfection of conjuctiva causes infolding of eyelashes that results in corneal scarring and blindness

azithromycin is very effective

15

chlamydia trachomatis lymphogranuloma venerum

caused by serotypes L1, 2, 3

transmitted venerally

symptom is painless papule progressing to ulcerating vesicle w/in 2 weeks

may progress to pain suppurating disease of regional lymph nodes

16

chlamydia treatment

tetracyclins

azythromycin

17

lab diagnosis of chlyamydial infection

share a group Ag

C pneumonia or psittaci have Ab assays (distinct serotypes)

C trachomatis- direct immunofluorescent, immunoassay, DNA probe, or PCR test

18

basic rickettsia properties

acquired from arthropods

obligate intracellular growth

cycle: enter by phagocytosis, multiple slowly, released by lysis

19

rickettsia prowazekii

causes typhus

incubation period is 10 days
abrupt fever and severe headache
rash follows 4 to 7 days later

untreated disease fatal except in in children

20

rickettsia prowazekii transmission

human - body louse - human - body louse

incubation is 10 days

21

rickettsia prowazekii treatment

tetracyclin

22

rickettsia prowazekii tests

observing rise in Ab titers, comparing acute convalescent

LFT

PCR

23

brill zinsser disease

latent rickettsia prowazekii reactivates after years or decades

24

rickettsia prowazekii can exist in flying squirrels and squirrel lice

ok

25

rickettsia typhi transmission

animals hosts- rats and ground squirrels and fleas

usually seen in southwest USA

26

rickettsia typhi symptoms

same as rickettsia prowazekii but less severe does not have high mortality rate

27

rickettsia diagnosis and treatment

same as for rickettsia prowazekii

tetracyclin

28

rickettsia rickettsii symptoms

rocky mountain spotted fever

fever, headache, arthritic pain, nasuea, vomiting

rash- begins on hands and feet and spreads to trunk

29

rickettsia rickettsii transmission

tick - transovarian tick -

ticks bite mammals or other humans

1 week incubation

30

rickettsia rickettsii treatment/diagnosis

same as R prowazekii

tetracyclin

31

rickettsia akari symptoms

causes rickettsia pox

primary skin lesion at bite site

fever chills headache and rash (like chicken pox)

32

rickettsia akari transmission

mouse- mouse mite

mouse mites bit humans

1 week incubation

33

coxiella symptoms

Q fever

interstitial pneumonia, fever, headache, elevated LFTs

34

coxiella transmission

sheep/goat/cow/cat - tick - etc.

humans get it from placental tissue/carcasses

35

ehrlichioses symptoms

fever, lymphocytopenia (low wbcs), elevated liver damageq

36

two types of erlichioses

monocytic- infects monocytes

granulocytic ehrlichiosis- infects granulocytes

37

COXIELLA TREATMENT

tetracyclines, flouroquinolones

38

ehrlichiosis transmission

ticks

39

ehrlichiosis treatment

tetracyclins

40

all of these pathogens are intracellular obligates

ok