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Flashcards in Neisseria Deck (21):
1

neissera morphology

gram negative diplococci

2

"meningococcus"

neisseria meningitidis

3

"gonococcus"

neisseria gonorrhoeae

4

neisseria meningitidis transmission

person-to-person via respiratory droplets

often occur in crowded conditions

carrier state in nasopharynx lasts days to months

small % it goes to blood

incubation is 1 week

5

where does neisseria meningitidis multiply?

outside cell

6

is neisseria meningitidis encapsulated?

yes- but gonorrhea is not

capsule has antiphagocytic properties that contributes to virulence

7

neisseria meningitidis virulence factors

capsule
protease that splits IgA
pili/OMPs- colonization and affect colony morpholgy

LOS- no O side chains but still acts as endotoxin

8

sub saharan meningitis belt

largest burden of meningococcal meningitis in the world

mostly type A

9

neisseria meningitidis serotypes

there are many different types/ outbreaks can occur when people from different areas congregate and there is no immuno protection to the foriegn serotypes

10

neisseria meningitidis symptoms

high fever, signs of meningitis, patechiae followed by large ecchymosis

11

waterhouse friederichsen syndrome

uncommone meningiococemia causes adrenal failure, circulator collapse and shock, death

12

treatment of neisseria meningitidis

penicllin, 3rd generation of cephalosporin

13

neisseria meningitidis vaccine

conjugate vaccine used in Africa

14

neisseria meningitidis grows on both blood agar and chocolate agar

ok

in opposition to haemophilius

15

gonococcus serotypes

over 100

16

gonococcus infection

STI via direct genital contact

also: rectal and pharyngeal

17

gonococcus virulence factors

pili- establish infection w/in an hour and impair phagocytosis

reach sub-epithelial CT, causing inflammation and pus

18

gonococcus complications of disseminated disease

arthritis-dermatitis syndrome

tendosynovitis

chronic pelvic inflammatory disease in females

19

gonococcus diagnosis

stain w/ exudate and PMN

like thayer martin selective medium

cultures w/ oxidase positive, gram - diplococci

gonococcus- glucose fermentation only

meningitidis- glucose and maltose only

20

gonococcus treatment

drug resistance 3 types:

plasmid mediated penicillinase

plasmid mediated tetracyclin

choromsome mediated resistant- broad resistance

use 3rd gen cephlasporin and tetracyclin or azythromicin for chlamydia

21

gonococcus vaccine

no vaccine