Diphtheriae Flashcards Preview

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Flashcards in Diphtheriae Deck (27):
1

corynebacterium morphology

pleomorphic gram positive rods

2

corynebacterium metabolism

aerobes

3

two classes of corynebacterium

diphtheriae and diphtheriods (all others)

4

corynebacterium transmission

aerosolized drop;ets

5

diphtheria isnt common in US anymore. Why?

successful vaccination

6

corynebacterium incubation

2-5 days

7

corynebacterium diphtheriae symptoms

fever, cough, sore throat

grey pseudomembrane forms on the back of the throat

bull neck

rarely: skin infection, stomach or lung

no: systemic infections

8

diphtheria toxin

causes systemic symptoms

lethal to eukaryotic cells

targets: heart, kidney, nervous system

blocks protein synthesis

9

corynebacterium diagnosis

done by identifying toxin

culture is difficult b/c must be grown on specialized medium (tellurite agar)

10

corynebacterium treatment

antitoxin neutralizes it- must be ordered from CDC

pt contacts treated w/ penicillin and reimmunized

11

corynebacterium vaccine

toxoid of DTX

DTaP

12

legionella morphology

gram negative rod

13

what other creatures can host legionella

ameboe

14

legionella symptoms

atypical pneumonia- not localized to a lobe

most probably go undiagnosed

can cause systemic disase- "pontiac fever"

15

legionella transmission

airborne- water cooling

not person to person

16

what cells does legionella infect?

macrophages- causes apoptosis or necrosis

has type 4 secretion system

17

legionella diagnositic tests

fastidious- agar w/ charcoal, iron, cysteine

direct Ab test in sputum- need to compare in two samples across weeks

18

mycoplasma morpholgy

smallest bacteria known

pleomorphy- no cell wall

no gram reactive

19

what gives mycoplasma its shape

lipoproteins in membrane form a protenaceous layer around it

also has cholesterol in membrane

20

what season is mycoplasma most common in?

summer

also has cycles every 4-8 year cycles

21

what does mycoplasma cause?

atypical pneumonia-

causes it in everyone

rarely: CNS, arthritis, autoimmune

22

how many serotypes of mycoplasma are there?

just 1 but doesnt give lifelong protection

23

mycoplasma transmission

respiratory droplets

24

P1 adhesins

binds glycoproteins for adhesion.

25

mycoplasma pathogenesis

binds using P1 adhesin, produces ROSs that cause damge and inflammation

prior immune responses can cause severe illness

26

mycoplasma diagnosis

PCR

cold agglutination test

27

mycoplasma treatment

erythromycin, tetracyclin