Flashcards in Diphtheriae Deck (27):
pleomorphic gram positive rods
two classes of corynebacterium
diphtheriae and diphtheriods (all others)
diphtheria isnt common in US anymore. Why?
corynebacterium diphtheriae symptoms
fever, cough, sore throat
grey pseudomembrane forms on the back of the throat
rarely: skin infection, stomach or lung
no: systemic infections
causes systemic symptoms
lethal to eukaryotic cells
targets: heart, kidney, nervous system
blocks protein synthesis
done by identifying toxin
culture is difficult b/c must be grown on specialized medium (tellurite agar)
antitoxin neutralizes it- must be ordered from CDC
pt contacts treated w/ penicillin and reimmunized
toxoid of DTX
gram negative rod
what other creatures can host legionella
atypical pneumonia- not localized to a lobe
most probably go undiagnosed
can cause systemic disase- "pontiac fever"
airborne- water cooling
not person to person
what cells does legionella infect?
macrophages- causes apoptosis or necrosis
has type 4 secretion system
legionella diagnositic tests
fastidious- agar w/ charcoal, iron, cysteine
direct Ab test in sputum- need to compare in two samples across weeks
smallest bacteria known
pleomorphy- no cell wall
no gram reactive
what gives mycoplasma its shape
lipoproteins in membrane form a protenaceous layer around it
also has cholesterol in membrane
what season is mycoplasma most common in?
also has cycles every 4-8 year cycles
what does mycoplasma cause?
causes it in everyone
rarely: CNS, arthritis, autoimmune
how many serotypes of mycoplasma are there?
just 1 but doesnt give lifelong protection
binds glycoproteins for adhesion.
binds using P1 adhesin, produces ROSs that cause damge and inflammation
prior immune responses can cause severe illness
cold agglutination test