ChlamydiaInfections Flashcards Preview

Micro Exam VI > ChlamydiaInfections > Flashcards

Flashcards in ChlamydiaInfections Deck (39):
1

What is the most reported STD in the US?

Chlamydia (C. Trachomatis)

2

Annual new infections of STDS:

50 million

3

Reason for number of new cases of bacterial STDs outnumbering existing cases:

They are treatable

4

Young people (15-24) represent what % of all new reported STIs?

50%

5

What patient group have the highest rate of STIs?

MSM

6

What patient group typically have lowest rate of STIs:

WSW

7

What is the most common species of Chlamydia:

Chlamydia Trachomatis

8

Chlamydia is a bacteria, but what makes it different from most bacteria?

They replicate ONLY within cells (intracellular pathogen). They LACK peptidoglycan.

9

C. Trachomatis is a common cause of:

Genital infection and conjunctivitis

10

Chlamydia characteristics:

Obligate intracellular pathogen (cannot make own ATP). Have a gram - like envelope but NO peptidoglycan. EB + RBs.

11

Two distinct stages of Chlamydia's life cycle:

Elementary: infectious. Reticulate: replicative (will divide)

12

Elementary bodies characteristics versus Replicative Bodies:

Elementary= small with rigid cell wall and adapted for extracellular survival. Reticulate: adapted for intracellular growth.

13

Life Cycle of Chlamydia:

Elementary bodies infect > EBs become reticulate bodies > INCLUSION formed of RBs> elementary bodies formed and released for more infection. All within 72 hours.

14

What is the host of C. Trachomatis:

Humans are ONLY known host.

15

The two biovars of C. Trachomatis:

Trachoma and LGV

16

**After biovars, how is C. Trachomatis differentiated:

By SEROVARS, based on major outer membrane protein (MOMP) (each leads to a different immune response)

17

Tropism of C. Trachomatis:

Tropism for NON-CILIATED, columnary, cuboidal or transitional epithelial cells

18

Disease by C. Trachomatis is due to:

Destruction of epithelia and the pro inflammatory cytokine response.

19

Without treatment, C. Trachomatis can lead to what in women:

Fibrosis (fertility implicated)

20

Diseases caused by C. Trachomatis (5):

Trachoma. Inclusion conjunctivitis. STI/Urogenital infections. Lymphogranuloma venereum (LGV). Infant pneumonia

21

Serovars of C. Trachomatis that cause Trachoma:

A, B, Ba, C

22

Serovars of C. Trachomatis that cause disease of the urogenital tract:

D-K

23

**Serovars of C. Trachomatis that cause LGV:

L1-L3

24

Why are LGV serovars more invasive than other serovars

Because they replicate in phagocytes

25

Cause of Chronic Conjunctivitis:

C. Trachomatis. Destruction of conjunctiva and folding.

26

What is the leading cause of preventable blindness?

Chronic Chlamydia Conjunctivitis

27

Acute conjunctivitis in sexually active adults commonly caused by:

C. Trachomatis

28

Presentation of Neonatal Conjunctivitis:

5-12 days following birth > eyelid swelling and discharge.

29

Cause of Neonatal Conjunctivitis:

Neonate exposed at birth to C. Trachomatis

30

**C. Trachomatis UG Infection in Men- Symptoms:

Urethritis with dysuria. Thin urethral MUCOPURULENT discharge.

31

**C. Trachomatis infection in men may progress to:

Reiter Syndrome: Triad: urethritis, conjunctivitis, polyarthritis

32

*C. Trachomatis UG Infection in Women mainly:

80% are asymptomatic and they serve as reservoir for infection

33

C. Trachomatis UG Infection in Women- Symptoms:

Mucopurulent Discharge. May also lead to pelvic inflammatory disease

34

Most common age range for infection by C. Trachomatis:

20-24 (15-24 overall)

35

What type of C. Trachomatis infection is highly prevalent in Africa, Asia and S. America or associated with travel?

Lymphogranuloma Venereum (LGV)

36

**Presentation of Lymphogranuloma Venereum:

PAINLESS lesion/papule at site of infection with inguinal lymphadenopathy. Proctitis is a common result of lymphatic spread.

37

**Diagnosis of C. Trachomatis:

Must have EPITHELIAL CELLS > iodine identifies glycogen inclusions in RETICULATE bodies

38

**Test of Choice for C. Trachomatis Diagnosis:

Nucleic acid amplification from **URINE or DISCHARGE** (Also used for gonorrhoeae)

39

**Treatment of C. Trachomatis Infection:

Doxycycline or Macrolides