Cholinomimetics Flashcards Preview

First Aid Step 1 material > Cholinomimetics > Flashcards

Flashcards in Cholinomimetics Deck (17):
1

Bethenachol MoA

direct agonist
Activates bowel and bladder smooth muscle
resistant to AChE

2

Bethanechol clinical use

Postoperative ileus, neurogenic ileus, urinary retention

3

Carbachol MoA

Direct Agonist
Carbon copy of acetylcholine.

4

Carbachol clinical use

Constricts pupil and relieves intraocular pressure in glaucoma

5

Methacholine MoA

direct agonist
Stimulates muscarinic receptors in airway when inhaled.

6

Methacholine clinical use

Challenge test for diagnosis of asthma

7

Pilocarpine MoA

Direct agonist
Contracts ciliary muscle of eye (open-angle glaucoma), pupillary sphincter (closed-angle glaucoma)
resistant to AChE

8

Pilocarpine clinical use

Potent stimulator of sweat, tears, and saliva
Open-angle and closed-angle glaucoma

9

Donepezil, galantamine, rivastigmine MoA and clinical use

anti-cholinesterase
Alzheimer Disease

10

Edrophonium MoA and clinical use

anti-cholinesterase

Historically, diagnosis of myasthenia gravis (extremely short acting). Myasthenia now diagnosed by anti-AChR Ab test.

11

Neostigmine MoA and clinical use

anti-cholinesterase

Postoperative and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular junction blockade (postoperative).

No CNS penetration

12

Physostigmine MoA and clinical use

anti-cholinesterase

Reverses Atropine overdose

Anticholinergic toxicity; crosses blood-brain barrier -> CNS.

13

Pyridostigmine MoA and clinical use

anti-cholinesterase

Myasthenia gravis (long acting); increases muscle strength

does not penetrate CNS.

14

With all cholinomimetic agents, watch for exacerbation of...? (3)

COPD, asthma, and peptic ulcers

15

What compounds irreversibly inhibit AChE and cause poisoning?

Organophosphates are often components of
insecticides; poisoning usually seen in farmers.

16

Antidote for AChE inhibitor Poisoning

Antidote—atropine (competitive inhibitor) +
pralidoxime (regenerates AChE if given early).

17

AChE inhibitor poisoning side effects? (DUMBBELSS)

Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle and CNS, Lacrimation, Sweating, and Salivation.