Sympathomimetics Flashcards Preview

First Aid Step 1 material > Sympathomimetics > Flashcards

Flashcards in Sympathomimetics Deck (25):
1

Albuterol, salmeterol effect what receptors?

β2 > β1

2

Albuterol, salmeterol clinical use

Albuterol for acute asthma; salmeterol for long- term asthma or COPD control.

3

Dobutamine effects what receptors?

β1 > β2, α

4

Dobutamine clinical use

Heart failure (HF) (inotropic > chronotropic), cardiac stress testing.

5

Dopamine effects what receptors?

D1 = D2 > β > α

6

Dopamine clinical use

Unstable bradycardia, HF, shock; inotropic and chronotropic α effects predominate at high doses.

7

Epinephrine effects what receptors?

β > α

8

Epinephrine clinical use

Anaphylaxis, asthma, open-angle glaucoma;
α effects predominate at high doses. Signi cantly stronger effect at β2-receptor than norepinephrine.

9

Isoproterenol effects what receptors?

β1 = β2

10

Isoproterenol clinical use

Electrophysiologic evaluation of tachyarrhythmias. Can worsen ischemia

11

Norepinephrine effects what receptors?

α1 > α2 > β1

12

Norepinephrine clinical use

Hypotension (but decreases renal perfusion). Significantly weaker effect at β2-receptor than epinephrine.

13

Phenylephrine effects what receptors?

α1 > α2

14

Phenylephrine clinical use?

Hypotension (vasoconstrictor), ocular procedures (mydriatic), rhinitis (decongestant).

15

Amphetamine MoA

Indirect general agonist, reuptake inhibitor, also releases stored catecholamines

16

Amphetamine clinical use

Narcolepsy, obesity, ADHD.

17

Cocaine MoA

Indirect general agonist, reuptake inhibitor

18

Cocaine clinical significance

Causes vasoconstriction and local anesthesia. Never give β-blockers if cocaine intoxication is
suspected (can lead to unopposed α1 activation and extreme hypertension).

19

Ephedrine MoA

Indirect general agonist, releases stored catecholamines

20

Ephedrine clinical use

Nasal decongestion, urinary incontinence, hypotension.

21

Clonidine and α-methyldopa MoA

Sympatholytics (α2-agonists)

22

Clonidine clinical use

Hypertensive urgency (limited situations); does not decrease renal blood flow
ADHD, Tourette syndrome

23

Clonidine toxicity

CNS depression, bradycardia, hypotension, respiratory depression, miosis

24

α-methyldopa clinical use

Hypertension in pregnancy

25

α-methyldopa toxicity

Direct Coombs ⊕ hemolysis, SLE-like syndrome