Flashcards in Sympathomimetics Deck (25):
Albuterol, salmeterol effect what receptors?
β2 > β1
Albuterol, salmeterol clinical use
Albuterol for acute asthma; salmeterol for long- term asthma or COPD control.
Dobutamine effects what receptors?
β1 > β2, α
Dobutamine clinical use
Heart failure (HF) (inotropic > chronotropic), cardiac stress testing.
Dopamine effects what receptors?
D1 = D2 > β > α
Dopamine clinical use
Unstable bradycardia, HF, shock; inotropic and chronotropic α effects predominate at high doses.
Epinephrine effects what receptors?
β > α
Epinephrine clinical use
Anaphylaxis, asthma, open-angle glaucoma;
α effects predominate at high doses. Signi cantly stronger effect at β2-receptor than norepinephrine.
Isoproterenol effects what receptors?
β1 = β2
Isoproterenol clinical use
Electrophysiologic evaluation of tachyarrhythmias. Can worsen ischemia
Norepinephrine effects what receptors?
α1 > α2 > β1
Norepinephrine clinical use
Hypotension (but decreases renal perfusion). Significantly weaker effect at β2-receptor than epinephrine.
Phenylephrine effects what receptors?
α1 > α2
Phenylephrine clinical use?
Hypotension (vasoconstrictor), ocular procedures (mydriatic), rhinitis (decongestant).
Indirect general agonist, reuptake inhibitor, also releases stored catecholamines
Amphetamine clinical use
Narcolepsy, obesity, ADHD.
Indirect general agonist, reuptake inhibitor
Cocaine clinical significance
Causes vasoconstriction and local anesthesia. Never give β-blockers if cocaine intoxication is
suspected (can lead to unopposed α1 activation and extreme hypertension).
Indirect general agonist, releases stored catecholamines
Ephedrine clinical use
Nasal decongestion, urinary incontinence, hypotension.
Clonidine and α-methyldopa MoA
Clonidine clinical use
Hypertensive urgency (limited situations); does not decrease renal blood flow
ADHD, Tourette syndrome
CNS depression, bradycardia, hypotension, respiratory depression, miosis
α-methyldopa clinical use
Hypertension in pregnancy