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Flashcards in alpha and beta blockers Deck (23):
1

Phenoxybenzamine MoA and use

nonselective, irreversible alpha blocker

Pheochromocytoma (used preoperatively) to prevent catecholamine (hypertensive) crisis

2

Phentolamine MoA and use

nonselective, reversible alpha blocker

Give to patients on MAO inhibitors who eat tyramine-containing foods

3

nonselective alpha blocker side effects

Orthostatic hypotension, reflex tachycardia

4

Prazosin, terazosin, doxazosin, tamsulosin MoA and use

α1 selective (-osin ending)

Urinary symptoms of BPH; PTSD (prazosin); hypertension (except tamsulosin)

5

α1 selective (-osin ending) blocker side effects

1st-dose orthostatic hypotension, dizziness, headache

6

Mirtazapine MoA and use

α2 selective blocker

depression

7

Mirtazapine side effects

Sedation, serum cholesterol, increased appetite

8

Acebutolol, atenolol, betaxolol, carvedilol, esmolol, labetalol, metoprolol, nadolol, nebivolol, pindolol, propranolol, timolol
(-olols)

MoA

β-blockers

9

β-blockers (-olols) clinical use (6)

Angina pectoris
MI
SVT (metoprolol, esmolol)
Hypertension
HF
Glaucoma (Timolol)

10

Effects of β-blockers on Angina pectoris

decrease heart rate and contractility, resulting in decreased O2 consumption

11

Effects of β-blockers on MI

β-blockers (metoprolol, carvedilol, and bisoprolol)
decrease mortality

12

Effects of Metoprolol, Esmolol on SVT

decrease AV conduction velocity (class II antiarrhythmic)

13

Effects of β-blockers on Hypertension

decrease cardiac output, decrease renin secretion (due to β1-receptor blockade on JGA cells)

14

Effects of β-blockers on HF

decrease mortality in chronic HF

15

Effects of Timolol on Glaucoma

decrease secretion of aqueous humor

16

β-blockers toxicity

Impotence, cardiovascular adverse effects (bradycardia, AV block, HF), CNS adverse effects (seizures, sedation, sleep alterations), and asthma/COPD exacerbations

17

which β-blocker has the side effect of dyslipidemia?

Metoprolol

18

β-blocker should be avoided in which patients due to risk of unopposed α-adrenergic receptor agonist activity?

cocaine users

19

Despite theoretical concern, what condition are β-blockers not contraindicated

Despite theoretical concern of masking hypoglycemia in diabetics, benefits likely outweigh risks

20

acebutolol (partial agonist), atenolol, betaxolol, esmolol, metoprolol have what selectivity?

β1-selective antagonists (β1 > β2)

21

nadolol, pindolol (partial agonist), propranolol, timolol have what selectivity?

Nonselective antagonists (β1 = β2)

22

carvedilol, labetalol have what selectivity?

Nonselective α- and β-antagonists

23

Which β-blocker activates NOS in vasculature and how?

Nebivolol combines cardiac-selective β1-adrenergic blockade with stimulation of β3-receptors, which activate nitric oxide synthase in the vasculature