Flashcards in Chromium Deck (9)
Sources & AI
Best: beef, cheese, peanuts, spices
Typical: orange and grape juice, broccoli
25-35 ug women/men
Serum 0.5 µg/ L
4 AA's that hold 4 chromium atoms together.
Glucose tolerance factor
Enhancers & Inhibitors
Enhancer: HCl, AA, picolinate (chelator/ made from niacin, protects chromium), vitamin C
Inhibitors: phytates, antiacids
Binds and transported via transferrin in +3 state with iron.
Can also bind to albumin.
Facilitates insulin receptor and beta subunit.
Upregulates GLUT4 which lowers blood glucose levels
Trivalent and Hexavalent
Nutrient or industrial contaminant.
Found in air, water, soil.
Hexavalent creates radicals within body due to its +6 charge.
Antioxidants can reduce hexavalent chromium.
Chromium and insulin
(Increases expression of insulin receptor)
Insulin promotes chromium entry into cells via transferrin receptors.
Released chromium atoms (4) bind to apochromodulin.
Chromodulin binds to beta subunits of insulin receptor.
Only in individuals receiving TPN.
Weight loss, neuropathy, insulin resistance, hyperglycemia, elevated free fatty acid concentrations.